DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG42255 and csmd2

DIOPT Version :9

Sequence 1:NP_729748.3 Gene:CG42255 / 39334 FlyBaseID:FBgn0259140 Length:3613 Species:Drosophila melanogaster
Sequence 2:XP_693833.6 Gene:csmd2 / 565460 ZFINID:ZDB-GENE-030616-39 Length:3604 Species:Danio rerio


Alignment Length:3097 Identity:617/3097 - (19%)
Similarity:997/3097 - (32%) Gaps:1148/3097 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly   496 CSHQRFFCGVTIRGPSGQLHYP------PNTADGDYQADERCPFIIRTNRNMVLNLTFTQFQLED 554
            |||       |:..|:|.:..|      ||.|:        |.::|....:..:.|.|..|.||:
Zfish    65 CSH-------TLHSPNGTIESPGYPYGYPNYAN--------CTWVIVAQEHNRIQLVFQGFALEE 114

  Fly   555 SADCTADFLQLHDGNSLSSRLIGRFCGSRLPMTNGSVITTQEQVFFWFRSDNQTQGKGFHVIWNS 619
            .    .|.|.::||....:.|..|..|.:||   ..:::|..::..|..||....|:||..::.:
Zfish   115 D----FDILSVYDGQPSPTNLRTRLTGFQLP---APIVSTGPRLTLWLLSDYAVSGQGFKAVYEA 172

  Fly   620 LP-FSC------------GETINL------------------------TST-------------- 633
            || ::|            |.|.|:                        ||:              
Zfish   173 LPSYTCGNPGQLLNGMQQGSTFNIGDKIRYSCNQGYVLEGHTVLSCLATSSGTAAWDFPLPYCRA 237

  Fly   634 ----------QTGVLRSPGYPGQARPELDCRWQLTAPFGYRLLLRFYDISL-------------G 675
                      |:||:.||.||.:.....||.|.:.|..|..:.|.|.|..|             |
Zfish   238 DDGCGGTLRGQSGVITSPNYPQEYNNNADCTWTILAEPGDTIALVFSDFQLEEDYDVLEITGTEG 302

  Fly   676 SSEASAGNCSQDSLIVYDSDRQLLRACQSIQPPPVYSSSNSLRLDFHTDAIRSDSSFQMHYE--- 737
            ||:...|    .:|                 |.|:.||.|.|||.|.:|.......|...|:   
Zfish   303 SSQWFTG----PNL-----------------PSPIISSKNWLRLHFTSDGNHKLRGFSAQYQVKK 346

  Fly   738 ----------------------------VVPGHPGCGGVYTESRGRISGYMNFEVCLYLIEQPRG 774
                                        |..||..|.......||:..| .:|.         ||
Zfish   347 MTELKSRGVKMLPSKDNHSKISVLSQMGVAQGHNMCPDPGIPERGKRKG-SDFR---------RG 401

  Fly   775 TQVKLVIDRVSLVQ---SLSCHYLKI-EIFDGRSTDAPLLRRICGSHEESELEPIISIGNVILVR 835
            ..|....|....:|   |::|  |:: :.:.|.|.|.|:.|                        
Zfish   402 ATVHFSCDEGYELQGSKSITC--LRVTDSYVGWSDDRPICR------------------------ 440

  Fly   836 YEYALSGVRLSKSFDLTYTRVCTGNFNTNSGIISTPNYPGPYFDDMTCTYNLTGPLDTAVRMRIT 900
                              ..:|.|.....||||::||:|..|.::..||:.:|.. |::..:::|
Zfish   441 ------------------APMCGGQLRGPSGIITSPNFPVQYDNNANCTWIITAS-DSSKVIKLT 486

  Fly   901 ----DLSLGTANNENDTSYL-DVYLSADQKR--HIVKST---DNLILLSHSNRASLVFHGSGGGR 955
                ||..|     .||..: |..:..||:.  |::..|   |.::..||....:.....:.|..
Zfish   487 FEEFDLERG-----YDTLTVGDGSVIGDQRTVFHVLSGTTTPDLVVSTSHQMWLNFKTDDTSGSL 546

  Fly   956 GMRLEYNFV-PNQCGGFLNEP-----GRRYVTAVRGTFCQWFIDFP-----GRKKISIHTLGPTP 1009
            |.::.|..: ...||    :|     |:|..|..|.....:|...|     |:|.|         
Zfish   547 GFKVSYEEIDQGGCG----DPGIPAYGKREGTGFRHGDKLYFECLPAFELVGKKNI--------- 598

  Fly  1010 SISIYDNSTSPGKLVNSYSGSVGDVFDGDLLTINLHTNWPRLEIYSIQFDIVQQDSCGGTFTARF 1074
                                           |...:..|...: .|..|      ||...||...
Zfish   599 -------------------------------TCQKNNQWSAKK-PSCVF------SCFFNFTTPS 625

  Fly  1075 GYIKSPNWPKNYGESQMCEWILRAPFGHRIELVVHNFTLEEEYSSTGCWTDWLEIRNGDSESSPL 1139
            |.:.|||:|:.||.:..|.|::.|....||.|..::.::|:::       |:|.|::|....||:
Zfish   626 GVLLSPNYPQEYGNNMHCVWLIIAKPESRINLAFNDLSMEKQF-------DFLSIKDGGKAESPI 683

  Fly  1140 IGRYCGNEIPSRIPSFGNVLHLKFKSDDSMEEKGFLLSWQQMGAGCGGKLSSSMGTIHSPHLLAG 1204
            :|.:.|:.:||.|.:.|:|..|:|.:|.:..::||.:::....              |:      
Zfish   684 LGTFSGDVLPSPITTSGHVARLEFLTDHTYTDRGFNITFTTFR--------------HN------ 728

  Fly  1205 NRGILACDWQIIVAEGSRV--SLQLRSNDNRICSGQLTLYDGPTTASNPIVIRCNGTIAKPLQST 1267
                 .|....:...|.|.  ||||.|:.:.:|....|...|..|      |.|       :...
Zfish   729 -----ECPDPGVPVNGKRFGESLQLGSSISFLCEEGFTKTHGSQT------ISC-------ILKD 775

  Fly  1268 GNRVLVRYDVGHDAPDGTDFMLNYQTNCRVRLEGLQGAIETPNFPENYPPGQDCEWDIRA--GGR 1330
            ||.|........:||            |...|:...|.|.:|.:||.|....:|||.|.|  |  
Zfish   776 GNVVWDNAVPRCEAP------------CGGNLKASSGIILSPGWPELYKEALNCEWIIEALPG-- 826

  Fly  1331 KNHLQLIFSHLSVEKFSSICLNDYVSLVDMLDDQTLSEQHLCTNDGLEP---ITTVGNRLLLRFK 1392
             ..:::||     :||.:....|   ::::.|.:..|...:.:..|.:.   :.:..|.|.|.|.
Zfish   827 -YPIKIIF-----DKFRTEVNYD---VLEVRDGRYPSSPLIGSYQGTQVPQFLISTSNFLYLLFT 882

  Fly  1393 SDSSVELQGFRAEYKRIGCGEHLRESGGRFESPNAPFSVDMDCVWIITASEGNQIRLLLHEVYFE 1457
            :|.|....|||..|      |.|:........|..|         :.....||       :.|..
Zfish   883 TDKSHSDIGFRIRY------ETLQLQSDHCVDPGIP---------VNGQRHGN-------DFYVG 925

  Fly  1458 APQIECRDAESSLSVSAPSGYNSSVVLFRSCHEETQTQTFTSPGNELVIRFVSSSAPSRKYFKAS 1522
            |          .::.|..:||.      .|.||..:.:    |..:.     |...||       
Zfish   926 A----------LVTFSCEAGYT------LSDHEPLECE----PNFQW-----SRPLPS------- 958

  Fly  1523 FVQVPASCGGYISASSGVLTTPGFHNHQDSKNVANYTSNIECVWTVEVTNGYGIRPHFEQFNL-- 1585
               ..|.|||:|..:||.:.:|||.:.        |..|:.|.|.:|.::|.|::..|..|:|  
Zfish   959 ---CDALCGGFIQGNSGTILSPGFPDF--------YPHNLNCTWMIETSHGKGVQFTFHTFHLES 1012

  Fly  1586 -------TDSGNCSVSFVELT--KLEPDNKEIFLEKTCGEDSPMIRIVHGRKLRVRFKSQAGTWG 1641
                   |::|:.|.....||  .|.|               |:               .||.:|
Zfish  1013 PHDHLLVTENGSFSQPLWRLTGSTLPP---------------PL---------------SAGLFG 1047

  Fly  1642 RFIMYFERQCGGRLSTGEGYLQSRLDEECSWLVTSPEGSKLSLIINQLE-CPKCNAVSQNCSEGL 1705
            .:.                 .|.|...:.|   .|.||..::.....|| |........:..:||
Zfish  1048 NYT-----------------AQIRFLSDFS---VSYEGFNITFSEYDLEPCEDPGIPPFSTRKGL 1092

  Fly  1706 QLLNDDDQVLL----YQMCRDHPANLIVPANNVRILTHGI-RLQAQFSTFENSCGGNITSASGSL 1765
            |....|..:..    |::  :.||.::......|:.:..: |..|:       ||.::|...|.|
Zfish  1093 QFGVGDALIFSCFPGYRL--EGPARVVCLGGRRRVWSSPLPRCVAE-------CGSSVTGKQGVL 1148

  Fly  1766 SSPNYPDSYPANIECVWSIRTRPGNALEITFEAMDIVRSEHCNDDFLEI--RSSVQGPLLALYCD 1828
            .|||||..|..:.||::||:|:||..:::  .|.|....|   ||.|::  .:|....||..:..
Zfish  1149 LSPNYPGYYGNDHECIYSIQTQPGKGIQL--RARDFHLEE---DDMLKVYDGNSNSARLLGTFTG 1208

  Fly  1829 KNLPETPL-VVHSELWIKFRSRPGNTAGGFRFRWTYVHNNEINSGINGTIEPPPPLFVSNEDQPF 1892
            ..|.:..| ...|.:|::|.|...||:.||...:|.....:..       :|..|.|        
Zfish  1209 TELMDVTLNSTSSSMWLEFISNSENTSKGFELHFTSFELVKCE-------DPGVPQF-------- 1258

  Fly  1893 TWRLFTDFKKVFVLQFEEYISGLILFDGYDDNALAVNIPVSPWRFTSSSNVVYLKTVNDALTHFR 1957
                  .||:                   :|........||     .|.:..|.....:.||..|
Zfish  1259 ------GFKR-------------------EDKGHFAGSTVS-----YSCDPGYSLKGPEVLTCLR 1293

  Fly  1958 LKWGVLDSNL---VASNLSLTTGGCTKELTLSHHGDIELSSPGYPHGYAPNLNCEWTIRSQFPSH 2019
            .:....||.|   ||.     .||..|:.::.     .:.|||||..|..||:|.|||.:...| 
Zfish  1294 GERRAWDSPLPQCVAE-----CGGKIKDESMG-----RILSPGYPAPYEHNLHCVWTIEAALGS- 1347

  Fly  2020 HIYAHSIIVDLEDYPACSADYLSIQSSRDLIKWKNE------LHACKASQIAP-VHGT-PYLRLQ 2076
            .|..|.::...|:.    .|.|.|        |...      |.....|.:.| :|.| ..:.||
Zfish  1348 TIGLHFLVFHTEEV----HDVLRI--------WDGPQDGGVLLRELSGSTLPPDLHSTFNSVSLQ 1400

  Fly  2077 FRSDVSINGTGFRAKLRTSCGSNMTGIVGTIPQENLFDECAWHIDVRPGRKIDIAINYNNMPPIA 2141
            |.:|...:..||..:...|..::                                          
Zfish  1401 FTTDFFTSKQGFALQFSVSTATS------------------------------------------ 1423

  Fly  2142 VCEAYGLIYDGVDEHASLLEHTRFGNQMGIRRTQFRTSGSHAYIKYHIGR----------SRING 2196
             |...|:..:|          ||.|:.        |..|.|...:...|.          :.||.
Zfish  1424 -CNDPGIPTNG----------TRIGDS--------REPGDHVLFQCDPGYLLQGATKITCTEINN 1469

  Fly  2197 LCLWNLTYREFNECNGEIQLNQQAPNYTIMSPGYPYLPHPHA-ECTWLVMAPPGETIAVDFDEQF 2260
            ...|.   .:...|:.....|...|:..|:||.||. |:||. ||.|        |:.|..|...
Zfish  1470 RFFWQ---PDPPTCSAPCGGNLTGPSGLILSPEYPE-PYPHGRECDW--------TVTVTLDHII 1522

  Fly  2261 ELSARHCDKEN----VEFFDGATKLARLL--LRTCRKPQNTVRTTGNLLLVHYQSQLNEPTGGFR 2319
            .|:..|...|.    :..:||...|:.||  ......| :.:.::.|.|.:.::|..:..:.||.
Zfish  1523 SLNFNHFSLEPSYDFLHIYDGPDSLSPLLGSFYGTDVP-DRIESSSNTLFLAFRSDASLSSNGFV 1586

  Fly  2320 LN--------------------------------------------------------------- 2321
            |.                                                               
Zfish  1587 LQYTENPRESCFEPGLVRNGTRVGTELKLGATVTYYCDSGYTLEGDATLTCIMGSDGKPGWNKPK 1651

  Fly  2322 -LSLSTCGGQFSASAGFISSENYPHLGGYPKPSVCEYSILLPKN-------AFIRLNITDLHLPY 2378
             :.::.||||:|...|.:.|..||  |.|.....|.||:::|::       ||.:..:.|:    
Zfish  1652 PVCIAPCGGQYSGLEGVVLSPGYP--GNYSSGRTCLYSVVVPRDYVVFSQFAFFQTALNDV---- 1710

  Fly  2379 DANGTSSDRLEIVDYEDRTQKLMV---LDGRTKTSILFTLNTNAATIRFVAVQNVNNYRGFKIRY 2440
                     :|:  |:..||...|   |.|......|....:|...|||.: :..::.|||.:.|
Zfish  1711 ---------VEV--YDGPTQHARVLSSLSGAHTGESLPLATSNQILIRFTS-KGQSSSRGFHLVY 1763

  Fly  2441 E-------------------RYVGT---------------------------------------- 2446
            :                   |..|.                                        
Zfish  1764 QAVPRTSATQCSSVPEPRHGRRTGNNFAVGAVVSFECNAGYVLEGPSAIECLTVPNALAQWNGSM 1828

  Fly  2447 ------CSRDINGASGDIVIPPMPQ-------SVWLRFCRLRISVPKGQRVRLNLLNLSNIRVVK 2498
                  |..::....|.|:.|..|:       .||      :|:||:|..:::.::         
Zfish  1829 PSCIVPCGGNLTQRIGTILSPGYPEPYLNSLSCVW------KITVPEGMGIQIQVI--------- 1878

  Fly  2499 RNDTNRSFMQIGRLESMAHFSFYNDANSLSKIAEFRIDGGYNGS---GIIESTDNYMLVVVMTNQ 2560
                  ||:.....:|:..|...::.:::.        |.::|:   .::.||.| .|.:...:.
Zfish  1879 ------SFVTEQNWDSLEVFDGGDNTDTML--------GSFSGTTVPALLNSTSN-QLYLHFFSD 1928

  Fly  2561 LDLSATPLRARYSSSEPTVCPPNIGDQATGSISIQSLLQVPGYHCTIKFVGTDSATLTFKVEEYL 2625
            :.:||...|..|.:...|.||             :.::.:.|                |:|.|.|
Zfish  1929 ISVSAAGFRLEYKTVSLTSCP-------------EPVVPMNG----------------FRVGERL 1964

  Fly  2626 FQTAGGPAVVFRDDITNIPVKAMYANVTNSFVSVVTSAGSVTLLNSKNVKLRRFRATYRRHN--- 2687
                                      ..|:.||.....| .||....::..  .....||.|   
Zfish  1965 --------------------------QMNNVVSFQCDPG-FTLQGVSHISC--MPGPVRRWNYPP 2000

  Fly  2688 ------CGGRLQAAEGVTIESPDLLTTLNDAYGEVECLWTLSNSNGYVLEGN-VTLTDRCDREYI 2745
                  |||..:..|| ||.||..   ..:.....:|.|.:....||..... :..:...:.:::
Zfish  2001 PLCIAQCGGIREEMEG-TILSPGF---PGNYPSNGDCTWRIYLPVGYGAHVQFLNFSTEANHDFL 2061

  Fly  2746 VI----FSGQSEVGRICRGMAMNSTLLERPFSTILY-HSE-SRLAQQSKFILQAW---------- 2794
            .|    |...:.:||. .|..:.|:||.....|.:| ||: |:.....:|..||:          
Zfish  2062 EIRNGPFDTSTVIGRF-SGQELPSSLLTTSHETTVYFHSDHSQNKPGFRFDYQAYELQECPDPEP 2125

  Fly  2795 --------------KSVS---------SGNAI---------RIDHRPSPPV-------------T 2814
                          :|:|         :|::|         ..|| |.|..             |
Zfish  2126 FHNGVVVGAGYNVGQSISFECYPGYHLTGHSILTCQHGTTRNWDH-PFPRCEVPCGGNITSDNGT 2189

  Fly  2815 ISSKNYLE----SKQRIWEFVTNDGLSLRLHF--LE---------------------RIFIVSSP 2852
            |.|..|.|    |....|......||.:||:|  |:                     .:|....|
Zfish  2190 IFSPGYPEDYPTSADCSWLITVAPGLGIRLNFTLLQVHGPQDFITVWDGPQETTRKLGVFTEGEP 2254

  Fly  2853 N---CSTDRLTVERYDQTTEE----YIEVTSLCGRQAANDILVPSARMRVIFQTNSNITGDGFSF 2910
            |   .||....:.|:..::|:    .|...:...:......::|:|  .::..:.....||...:
Zfish  2255 NNPPSSTSNQVLIRFRSSSEKGGLFKINYQAYRLQFCLPPPIIPNA--EILMASKEFKIGDIVRY 2317

  Fly  2911 QVIPSCDSVLLAGAEIQTLASPSWAAFRGRQFNCSYTFYAHDNHQVVVSVRTRGRPWASYACSRS 2975
            :.:|...   |.|..|||....:...|.|...:|..|                            
Zfish  2318 RCLPGYH---LNGNSIQTCRLGTHLEFDGPPPSCDIT---------------------------- 2351

  Fly  2976 YFEAYRRGDGNGVGEESIGRLCPEFEVKGNGRVRLRYVSPLSRWFEMQYQLIQCGGNYSTSFTLR 3040
                                 ||..||.                            ..||...| 
Zfish  2352 ---------------------CPMNEVL----------------------------TASTGVIL- 2366

  Fly  3041 PPQNEDSSVYAHNTLCEWRITAPPQHAVVIEFKYFDMESSRNCGFDSLTIYRGHVVSEEQRTGL- 3104
             .|:..||: .|...|.|.:.....:.:....::|  ::||.  ||.|.|:.|    ..:::.| 
Zfish  2367 -SQSPGSSL-PHFESCSWLVKVDSGYNITFTVEHF--QTSRQ--FDELEIFDG----PSRQSPLL 2421

  Fly  3105 --LCGNVTNPETIIVNSNEALIVLTTDSSNSYRGFLASVRFT 3144
              |.||.::|.:|..::|:..:..:.|.::|::||  .:|::
Zfish  2422 ISLSGNYSSPLSITSSANKVYLHWSFDHTSSHKGF--RIRYS 2461

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG42255NP_729748.3 EGF_CA 156..190 CDD:238011
EGF_CA 192..233 CDD:238011
EGF_CA 290..328 CDD:214542
EGF_CA 330..374 CDD:214542
EGF 427..455 CDD:278437
EGF_CA 462..496 CDD:238011 617/3097 (20%)
CUB 503..619 CDD:238001 30/121 (25%)
CUB 624..738 CDD:238001 39/217 (18%)
CUB 745..854 CDD:238001 18/112 (16%)
CUB 857..963 CDD:238001 31/115 (27%)
CUB 1066..1179 CDD:238001 35/112 (31%)
CUB 1185..1293 CDD:238001 20/109 (18%)
CUB 1303..1406 CDD:238001 29/107 (27%)
CUB 1411..1523 CDD:238001 18/111 (16%)
CUB 1530..1648 CDD:238001 30/128 (23%)
CUB 1754..1862 CDD:238001 37/110 (34%)
CUB 1979..2091 CDD:238001 32/119 (27%)
CUB 2096..2193 CDD:294042 10/106 (9%)
CUB 2210..2321 CDD:238001 31/117 (26%)
CUB 2327..2441 CDD:238001 33/123 (27%)
CUB 2688..2782 CDD:294042 25/100 (25%)
CUB 2810..2911 CDD:238001 26/147 (18%)
CUB 3029..3143 CDD:238001 28/116 (24%)
CUB 3169..3249 CDD:294042
CUB 3499..3607 CDD:238001
csmd2XP_693833.6 CUB 65..172 CDD:238001 33/128 (26%)
CCP 178..236 CDD:153056 6/57 (11%)
CUB 241..344 CDD:238001 33/123 (27%)
CCP 382..440 CDD:153056 17/69 (25%)
CUB 444..553 CDD:238001 30/114 (26%)
CCP 560..614 CDD:153056 15/98 (15%)
CUB 617..724 CDD:238001 35/113 (31%)
CCP 730..788 CDD:153056 17/70 (24%)
CUB 791..898 CDD:238001 32/123 (26%)
CCP 906..959 CDD:153056 16/103 (16%)
CUB 963..1071 CDD:238001 36/165 (22%)
CCP 1078..1134 CDD:153056 10/57 (18%)
CUB 1137..1244 CDD:238001 37/111 (33%)
CCP 1250..1307 CDD:153056 16/101 (16%)
CUB 1310..1418 CDD:238001 34/125 (27%)
CCP 1424..1480 CDD:153056 13/76 (17%)
CUB 1484..1590 CDD:238001 31/115 (27%)
CCP 1597..1655 CDD:153056 0/57 (0%)
CUB 1658..1765 CDD:238001 34/124 (27%)
CCP 1774..1832 CDD:153056 2/57 (4%)
CUB 1835..1940 CDD:238001 24/134 (18%)
CCP 1948..2004 CDD:153056 16/113 (14%)
CUB 2007..2114 CDD:238001 27/111 (24%)
CCP 2120..2175 CDD:214478 8/55 (15%)
CUB 2179..2285 CDD:238001 21/105 (20%)
CCP 2291..2348 CDD:153056 12/61 (20%)
CUB 2356..2462 CDD:238001 31/147 (21%)
CCP 2465..2524 CDD:153056
PHA02927 2523..2767 CDD:222943
CCP 2528..2586 CDD:153056
Sushi 2590..2647 CDD:278512
CCP 2655..2708 CDD:153056
CCP 2713..2767 CDD:153056
PHA02927 2765..3006 CDD:222943
CCP 2771..2825 CDD:153056
CCP 2829..2887 CDD:153056
Sushi 2892..2945 CDD:278512
PHA02927 2953..3242 CDD:222943
CCP 2953..3006 CDD:153056
Sushi 3011..3065 CDD:278512
CCP 3070..3126 CDD:153056
PHA02927 3130..3363 CDD:222943
CCP 3130..3183 CDD:153056
CCP 3188..3242 CDD:153056
CCP 3249..3304 CDD:153056
CCP 3308..3363 CDD:153056
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
21.910

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