DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42255 and bmp1b

DIOPT Version :9

Sequence 1:	NP_729748.3	Gene:	CG42255 / 39334	FlyBaseID:	FBgn0259140	Length:	3613	Species:	Drosophila melanogaster
Sequence 2:	XP_005155463.1	Gene:	bmp1b / 559877	ZFINID:	ZDB-GENE-060818-2	Length:	970	Species:	Danio rerio

Alignment Length:	815	Identity:	199/815 - (24%)
Similarity:	323/815 - (39%)	Gaps:	179/815 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   965 PNQCGGFLNEPGRRYVTAVRGTFCQWFIDFPGRKKISIHTLGPT-------------PSISIYDN 1016
            |..|..|:...|........|..|..|       .|.:|.||..             ..:.|:..
Zfish   165 PCGCCSFVGRRGGGPQAISIGKNCDKF-------GIVVHELGHVIGFWHEHTRPDRDEHVDIFRE 222

  Fly  1017 STSPGKLVNSYS------GSVGDVFDGDLLT----------INLHTNWPRLEIYSIQFDIVQQ-- 1063
            :..||:..|...      .|:|:|:|.|.:.          |.|.|..|:.::..::..|.|:
Zfish   223 NIQPGQEYNFIKMEPDDVDSLGEVYDFDSIMHYARNTFSRGIYLDTMLPKYDVDGVRPPIGQRTR 287

  Fly  1064 ---------------DSCGGTFTARFGYIKSPNWPKNYGESQMCEWILRAPFGHRIELVVHNFTL 1113
                           ..||.:.....|...||.:|..|.....|.|.:....|.:|.|   |||.
Zfish   288 LSKGDIAQARKLYRCPRCGESLQDSAGNFSSPGFPNGYAAYLHCIWRISVTPGEKIVL---NFTS 349

  Fly  1114 EEEYSSTGCWTDWLEIRNGDSESSPLIGRYCGNEIPSRIPSFGNVLHLKFKSDDSMEEKGFLLSW 1178
            .:.|.|..||.|::|:|:|...|:||.||.||:::|..|.|..:.|.::|:|..:...|||...:
Zfish   350 MDLYRSNLCWYDYVEVRDGYGRSAPLKGRICGDQLPEAIVSTDSELWIEFRSTSNWVGKGFSAVY 414

  Fly  1179 QQMGAGCGGKLSSSMGTIHSPHLLAGNRGILACDWQIIVAEGSRV-----SLQLRSNDNRICS-G 1237
            :   |.|||::....|.|.||:.....|...||.|:|:|.||..|     |.::..:||  |: .
Zfish   415 E---AICGGEVRRDSGQIESPNYPDDYRPNKACIWKIVVPEGFHVGLVFQSFEIEKHDN--CAYD 474

  Fly  1238 QLTLYDGPTTASNPIVIRCNGTIAKP--LQSTGNRVLVRYDVGHDAPDGTDFMLNY--------- 1291
            .|.:.|| .:.|:|::.|..| ..||  .:|:.|::.::: |...:.:...|..|:
Zfish   475 YLEVRDG-DSESSPLLGRFCG-YEKPDDFKSSSNQLWMKF-VSDGSVNKAGFAANFFKEIDECSR 536

  Fly  1292 --QTNCRVR---------------------------------LEGLQGAIETPNFPENYPPGQDC 1321
              ..:|..|                                 :..|.|:..:|.:|:.|||.::|
Zfish   537 PDNAHCEQRCINTLGSFHCACDPGFELAPDRRSCAAAACGGFISKLNGSFTSPGWPQEYPPNKNC 601

  Fly  1322 EWDIRAGGRKNHLQLIFSHLSVEKFSSICLNDYVSLVDMLDDQTLSEQHLCTNDGLEPITTVGNR 1386
            .|.:.| ..:..:.|:|....:|. :.:|..|||.:...|..........|..:..|.||:..|.
Zfish   602 VWQLIA-PVQYRITLLFDAFEMEG-NDVCKYDYVEVHSGLSADGKLHGKFCGTEKPEAITSQLNS 664

  Fly  1387 LLLRFKSDSSVELQGFRAEY------------------------------------------KRI 1409
            :.:.||||::|..:||:|::                                          |.:
Zfish   665 MSVEFKSDNTVSKRGFKAQFFSDMDECSRENGGCQHECVNTFGSYSCQCRSGFVLHSNKHDCKEV 729

  Fly  1410 GCGEHLRESGGRFESPNAP--FSVDMDCVWIITASEGNQIRLLLHEVYFEAPQIECRDAESSLSV 1472
            ||.:.:....|...|||.|  :.....|.|.::.:.|::|:|...|:..||.| ||  |...|.:
Zfish   730 GCDQAITSVSGLITSPNWPDKYPSKKACTWTLSTTPGHRIKLAFEEIDMEAHQ-EC--AYDHLEI 791

  Fly  1473 -SAPSGYNSSVVLFRSCHEETQTQTFTSPGNELVIRFVSSSAPSRKYFKASFVQVPASCGGYISA 1536
             ...:|..:||..|  |..:..:...:| .|.:.:||.|.::..::.||||.   .|.|||.:.|
Zfish   792 YDGQNGRATSVGRF--CGSKKPSPVISS-SNTMFLRFFSDNSVQKRGFKASH---SAECGGSLKA 850

  Fly  1537 SSGVLTTPGFHNH-QDSKNVANYTSNIECVWTVEVTNGYGIRPHFEQFNLTDSGNCSVSFVELTK 1600
            .   :.|...::| |...|  ||....:|.|.:....|||:...|..|.:.:..:|...:|||..
Zfish   851 E---IKTKDLYSHAQFGDN--NYPGASDCQWVISAEKGYGVELIFHTFEIEEEADCGYDYVELFD 910

  Fly  1601 LEPDNKEIFLEKTCGEDSPMIRIVHGRKLRVRFKS 1635
             ..|.|...|.:.||...|......|..:.::|.|
Zfish   911 -GGDVKAPRLGRYCGSGPPEEIYSAGDAIVIKFHS 944

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42255	NP_729748.3	EGF_CA	156..190	CDD:238011
		EGF_CA	192..233	CDD:238011
		EGF_CA	290..328	CDD:214542
		EGF_CA	330..374	CDD:214542
		EGF	427..455	CDD:278437
		EGF_CA	462..496	CDD:238011
		CUB	503..619	CDD:238001
		CUB	624..738	CDD:238001
		CUB	745..854	CDD:238001
		CUB	857..963	CDD:238001
		CUB	1066..1179	CDD:238001	39/112 (35%)
		CUB	1185..1293	CDD:238001	34/126 (27%)
		CUB	1303..1406	CDD:238001	30/102 (29%)
		CUB	1411..1523	CDD:238001	32/114 (28%)
		CUB	1530..1648	CDD:238001	30/107 (28%)
		CUB	1754..1862	CDD:238001
		CUB	1979..2091	CDD:238001
		CUB	2096..2193	CDD:294042
		CUB	2210..2321	CDD:238001
		CUB	2327..2441	CDD:238001
		CUB	2688..2782	CDD:294042
		CUB	2810..2911	CDD:238001
		CUB	3029..3143	CDD:238001
		CUB	3169..3249	CDD:294042
		CUB	3499..3607	CDD:238001
bmp1b	XP_005155463.1	ZnMc_BMP1_TLD	109..303	CDD:239808	26/144 (18%)
		Astacin	111..303	CDD:279708	26/144 (18%)
		CUB	305..414	CDD:278839	39/111 (35%)
		CUB	418..527	CDD:278839	33/113 (29%)
		EGF_CA	530..570	CDD:214542	2/39 (5%)
		CUB	575..684	CDD:278839	31/110 (28%)
		FXa_inhibition	691..726	CDD:291342	0/34 (0%)
		CUB	731..840	CDD:278839	32/114 (28%)
		CUB	844..957	CDD:278839	30/107 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3714
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900