DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42255 and tll1

DIOPT Version :9

Sequence 1:	NP_729748.3	Gene:	CG42255 / 39334	FlyBaseID:	FBgn0259140	Length:	3613	Species:	Drosophila melanogaster
Sequence 2:	NP_571085.1	Gene:	tll1 / 474335	ZFINID:	ZDB-GENE-041020-1	Length:	1022	Species:	Danio rerio

Alignment Length:	746	Identity:	177/746 - (23%)
Similarity:	304/746 - (40%)	Gaps:	174/746 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   960 EYNFVPNQCGGFLNEPGRRYVTAVRGTFCQWFIDFPGRKKISIHTLGPTPSISIYDNSTSPGKLV 1024
            ||||:..:.|. :|..|..|             ||..    .:|....|.|..::.::..|.:..
Zfish   282 EYNFIKMEPGD-VNSLGEPY-------------DFDS----IMHYARNTFSRGMFLDTILPSRDE 328

  Fly  1025 NSYSGSVGD---VFDGDLLTINLHTNWPRLEIYSIQFDIVQQDSCGGTFTARFGYIKSPNWPKNY 1086
            |....::|.   :..||:               |....:.:..:||.|.....|...||.:|..|
Zfish   329 NGVRPAIGQRTRLSKGDI---------------SQAKKLYRCPACGETLQDSVGNFSSPGYPNGY 378

  Fly  1087 GESQMCEWILRAPFGHRIELVVHNFTLEEEYSSTGCWTDWLEIRNGDSESSPLIGRYCGNEIPSR 1151
            .....|.|.:....|.:|.|   |||..:.|.|:.||.|::|:|:|....:||:||:||::||..
Zfish   379 PSYTHCVWRISVTPGEKIVL---NFTTMDLYKSSLCWYDYIEVRDGYWRKAPLLGRFCGDKIPEV 440

  Fly  1152 IPSFGNVLHLKFKSDDSMEEKGFLLSWQQMGAGCGGKLSSSMGTIHSPHLLAGNRGILACDWQII 1216
            :.|..:.:.::|:|..:...|||...::   |.|||::|...|.|.||:.....|....|.|:|.
Zfish   441 LVSTDSRMWIEFRSSSNWVGKGFAAVYE---AICGGEISKDSGQIQSPNYPDDYRPSKECVWRIT 502

  Fly  1217 VAEGSRVSL-----QLRSNDNRICS-GQLTLYDGPTTASNPIVIR-CNGTIAKPLQSTGNRVLVR 1274
            |:||..|.|     ::..:|:  |: ..|.:.|| .:.::|::.| |.....:.::||.|.:.::
Zfish   503 VSEGYSVGLSFQVFEIERHDS--CAYDYLEVRDG-LSENSPLIGRFCGYDKPEDIRSTSNNLWMK 564

  Fly  1275 Y---------------------------------------------DVGHD-APDGTDFMLNYQT 1293
            :                                             |.|:: |||    ..:.:.
Zfish   565 FVSDGTVNKAGFAANFFKEEDECLKPDNGGCEQRCVNTLGSFKCACDPGYELAPD----KKSCEA 625

  Fly  1294 NCRVRLEGLQGAIETPNFPENYPPGQDCEWDIRAGGRKNHLQLIFSHLSVEKFSSICLNDYVSLV 1358
            .|...|..|.|.|.||.:|:.|||.::|.|.:.| ..:..:.:.|....:|. :.:|..|||.:.
Zfish   626 ACGGLLTKLNGTITTPGWPKEYPPNKNCVWQVVA-PTQYRISMQFEAFELEG-NEVCKYDYVEVR 688

  Fly  1359 DMLDDQTLSEQHLCTNDGLEPITTVGNRLLLRFKSDSSVELQGFRAEY----------------- 1406
            ..|...:......|..:..|.||:..|.:.:.||||::|..:||:|.:
Zfish   689 SGLSSDSKLHGKYCGTEVPEVITSQYNNMRIEFKSDNTVSKKGFKAHFFSDKDECSKDNGGCQHE 753

  Fly  1407 -------------------------KRIGCGEHLRESGGRFESPNAP--FSVDMDCVWIITASEG 1444
                                     |...|...:..:.|...|||.|  :....:|.|.|||:.|
Zfish   754 CINTIGSYVCQCRNGFILHENKHDCKEAECEHKIHSTTGTISSPNWPDKYPSRKECTWDITATPG 818

  Fly  1445 NQIRLLLHEVYFEAPQ------IECRDAESSLSVSAPSGYNSSVVLFRSCHEETQTQTFTSPGNE 1503
            :::::..:|...|..|      :|..|.:|          :.:.:|.|.|..:. .:...|.||:
Zfish   819 HRVKISFNEFEIEQHQECAYDHLEAFDGDS----------DKTPILSRLCGNKI-PEPLISTGNK 872

  Fly  1504 LVIRFVSSSAPSRKYFKASFVQVPASCGGYISASSGVLTTPGFHNH-QDSKNVANYTSNIECVWT 1567
            :.:||:|.::..||.|:|:.   ...|||.:.|.:   .....::| |...|  ||..:.:|.|.
Zfish   873 MYLRFISDASVQRKGFQATH---STECGGRLKAEA---RQKNLYSHAQFGDN--NYPGHTDCEWL 929

  Fly  1568 VEVTNGYGIRPHFEQFNLTDSGNCSVSFVEL 1598
            :...:||||...|..|.:.:..:|...::||
Zfish   930 IVAESGYGIELTFTTFEVEEEADCGYDYIEL 960

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42255	NP_729748.3	EGF_CA	156..190	CDD:238011
		EGF_CA	192..233	CDD:238011
		EGF_CA	290..328	CDD:214542
		EGF_CA	330..374	CDD:214542
		EGF	427..455	CDD:278437
		EGF_CA	462..496	CDD:238011
		CUB	503..619	CDD:238001
		CUB	624..738	CDD:238001
		CUB	745..854	CDD:238001
		CUB	857..963	CDD:238001	2/2 (100%)
		CUB	1066..1179	CDD:238001	38/112 (34%)
		CUB	1185..1293	CDD:238001	33/160 (21%)
		CUB	1303..1406	CDD:238001	31/102 (30%)
		CUB	1411..1523	CDD:238001	31/119 (26%)
		CUB	1530..1648	CDD:238001	20/70 (29%)
		CUB	1754..1862	CDD:238001
		CUB	1979..2091	CDD:238001
		CUB	2096..2193	CDD:294042
		CUB	2210..2321	CDD:238001
		CUB	2327..2441	CDD:238001
		CUB	2688..2782	CDD:294042
		CUB	2810..2911	CDD:238001
		CUB	3029..3143	CDD:238001
		CUB	3169..3249	CDD:294042
		CUB	3499..3607	CDD:238001
tll1	NP_571085.1	ZnMc_BMP1_TLD	157..356	CDD:239808	19/106 (18%)
		Astacin	164..357	CDD:279708	19/107 (18%)
		CUB	358..467	CDD:278839	38/111 (34%)
		CUB	471..580	CDD:278839	28/111 (25%)
		FXa_inhibition	591..623	CDD:291342	5/35 (14%)
		CUB	627..736	CDD:278839	34/110 (31%)
		FXa_inhibition	743..778	CDD:291342	0/34 (0%)
		CUB	783..892	CDD:278839	31/119 (26%)
		CUB	896..1009	CDD:278839	20/70 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3714
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810