Protein Alignment Cubn2 and ASTL

DIOPT Version :10

• Sequence 1: NP_729748.3
• Gene: Cubn2 / 39334
• FlyBaseID: FBgn0259140
• Length: 3613
• Species: Drosophila melanogaster
• Sequence 2: XP_011509507.1
• Gene: ASTL / 431705
• HGNCID: 31704
• Length: 436
• Species: Homo sapiens
• Alignment Length: 409
• Identity: 83/409 - (20%)
• Similarity: 119/409 - (29%)
• Gaps: 178/409 - (43%)

  Fly   447 CICQP-GYSGV-VCNSSDACHPSPCLNGGTCRLLPDAKYQCVCPRGYTGTTCSHQRFFCGVTIRG 509
            |:..| |..|: ||         |||:|....|.......|.   |..||:     |..|:|..|
Human     4 CLVSPVGAPGICVC---------PCLSGPGVILGAPLASSCA---GACGTS-----FPDGLTPEG 51

  Fly   510 --PSGQLHYP-----------PNTA---DGDYQADERCPFIIRTNRNMVLNLTFTQFQLEDSADC 558
              .||....|           |.::   :||         |||.:...:|:.|..::.:..|...
Human    52 TQASGDKDIPAINQGLILEETPESSFLIEGD---------IIRPSPFRLLSATSNKWPMGGSGVV 107

  Fly   559 TADFLQLHDGNSLSSRL--------------------------------------------IGRF 579
            ...||       |||:.                                            :||.
Human   108 EVPFL-------LSSKYDEPSRQVILEALAEFERSTCIRFVTYQDQRDFISIIPMYGCFSSVGRS 165

  Fly   580 CGSRLP------MTNGSVITTQEQVF---FWFRSDNQTQGKGFHVIWNS-LPFSCGETINLTSTQ 634
            .|.::.      :..|..|...|.:.   ||.......:.:...|.||. ||   |..||...:|
Human   166 GGMQVVSLAPTCLQKGRGIVLHELMHVLGFWHEHTRADRDRYIRVNWNEILP---GFEINFIKSQ 227

  Fly   635 TGVLRSP-----------------GYP------------GQARPELDCRWQLTAPFGYRLLLRFY 670
            :..:.:|                 |.|            ||       ||.|:|....| :|:.|
Human   228 SSNMLTPYDYSSVMHYGRLAFSRRGLPTITPLWAPSVHIGQ-------RWNLSASDITR-VLKLY 284

  Fly   671 DIS--------LGSSEASAGNCSQDSLIVYDSDRQLLRA--CQSIQPPPVYSSSNSLRLDFHTDA 725
            ..|        .||...|.|.....:.:   |.::||.|  .:|..|.|..||:..
Human   285 GCSPSGPRPRGRGSHAHSTGRSPAPASL---SLQRLLEALSAESRSPDPSGSSAGG--------- 337

  Fly   726 IRSDSSFQMHYEVVPGHPG 744
                       :.||..||
Human   338 -----------QPVPAGPG 345

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cubn2	NP_729748.3	cubilin_NTD	38..141	CDD:412063
		EGF_CA	156..190	CDD:238011
		EGF_CA	192..233	CDD:238011
		EGF_CA	290..328	CDD:214542
		EGF_CA	330..374	CDD:214542
		EGF	427..455	CDD:394967	3/8 (38%)
		EGF_CA	462..496	CDD:238011	9/33 (27%)
		CUB	503..619	CDD:238001	30/184 (16%)
		CUB	624..738	CDD:238001	30/152 (20%)
		CUB	745..854	CDD:238001	83/409 (20%)
		CUB	857..963	CDD:238001
		CUB	1066..1179	CDD:238001
		CUB	1185..1293	CDD:238001
		CUB	1303..1406	CDD:238001
		CUB	1411..1523	CDD:238001
		CUB	1530..1648	CDD:238001
		CUB	1754..1862	CDD:238001
		CUB	1979..2091	CDD:238001
		CUB	2210..2321	CDD:238001
		CUB	2327..2441	CDD:238001
		CUB	2688..2782	CDD:412131
		CUB	2810..2911	CDD:238001
		CUB	3029..3143	CDD:238001
		CUB	3169..3249	CDD:412131
		CUB	3499..3607	CDD:238001
ASTL	XP_011509507.1	ZnMc	105..286	CDD:469599	34/198 (17%)
		PHA03307	273..>428	CDD:223039	22/97 (23%)