DRSC/TRiP Functional Genomics Resources

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Protein Alignment Cubn2 and tld

DIOPT Version :10

Sequence 1:NP_729748.3 Gene:Cubn2 / 39334 FlyBaseID:FBgn0259140 Length:3613 Species:Drosophila melanogaster
Sequence 2:NP_524487.2 Gene:tld / 42945 FlyBaseID:FBgn0003719 Length:1067 Species:Drosophila melanogaster


Alignment Length:1265 Identity:250/1265 - (19%)
Similarity:408/1265 - (32%) Gaps:481/1265 - (38%)


- Green bases have known domain annotations that are detailed below.


  Fly   672 ISLGSSEASAGNCSQDSLIVYDSDRQLLRACQSIQPPPVYSSSNSLRLDFHTDAIRSDSSFQMHY 736
            ||:|.      ||.:..:|:::...                     .:.||.:..|.|.  ..|.
  Fly   217 ISIGR------NCEKFGIIIHELGH---------------------TIGFHHEHARGDR--DKHI 252

  Fly   737 EVVPGHPGCGGVYTESRGRISGYMNFEVCLYLIEQPRGTQVKLV-IDRVSLVQSLSCHYLKIEIF 800
            .:..|:...|..|           ||:|.     .|....:.|: .|..|::     ||.|    
  Fly   253 VINKGNIMRGQEY-----------NFDVL-----SPEEVDLPLLPYDLNSIM-----HYAK---- 292

  Fly   801 DGRSTDAPLLRRIC------GSHEESELEPIISIGNVILVRYEYALSGVRLSKSFDLTYTRVCTG 859
             ...:.:|.|..|.      |:|.|......:|.|:::.....|..:.              |..
  Fly   293 -NSFSKSPYLDTITPIGIPPGTHLELGQRKRLSRGDIVQANLLYKCAS--------------CGR 342

  Fly   860 NFNTNSGIISTPNYPGPYFDDMTCTYNLTGPLDTAVRMRITDLSLGTANNENDTSYLDVYLSADQ 924
            .:..|||.|.:|::          .|:..|.|..                               
  Fly   343 TYQQNSGHIVSPHF----------IYSGNGVLSE------------------------------- 366

  Fly   925 KRHIVKSTDNLILLSHSNRASLVFHGSG-GGRGMRLEYNFVPNQCGGFLNEPGRRYVTAVRGTFC 988
                                   |.||| .|.....|..|..:.                  |.|
  Fly   367 -----------------------FEGSGDAGEDPSAESEFDASL------------------TNC 390

  Fly   989 QWFIDFPGRKKISIH--TLGPTPS-------ISIYDNSTSPGKLVNSYSGSVGDVFDGDLLTINL 1044
            :|.|.....:|:.:|  .|....|       :.|.|.......||....|:|    .|:::|   
  Fly   391 EWRITATNGEKVILHLQQLHLMSSDDCTQDYLEIRDGYWHKSPLVRRICGNV----SGEVIT--- 448

  Fly  1045 HTNWPRLEI-------------YSIQFDIVQQDSCGGTF-TARFGYIKSPNWPKNYGESQMCEWI 1095
             |...|:.:             :..:|::|    |||.. ..:...|.|||:|.:|...:.|.|.
  Fly   449 -TQTSRMLLNYVNRNAAKGYRGFKARFEVV----CGGDLKLTKDQSIDSPNYPMDYMPDKECVWR 508

  Fly  1096 LRAPFGHRIELVVHNFTLEEEYSSTGCWTDWLEIRNGDSESSPLIGRYCGNEIPSRIPSFGNVLH 1160
            :.||..|::.|...:|.||:.   .||..|::|||:|:...|.||||:||:::|..|.:..|.::
  Fly   509 ITAPDNHQVALKFQSFELEKH---DGCAYDFVEIRDGNHSDSRLIGRFCGDKLPPNIKTRSNQMY 570

  Fly  1161 LKFKSDDSMEEKGFLLSWQQMGAGCGGKLSSSMGTIHS-PHLLAGNRGILACDWQIIVAEGSRVS 1224
            ::|.||.|:::.||       .|.....:.....|.|. .||.....|...|        |.|..
  Fly   571 IRFVSDSSVQKLGF-------SAALMLDVDECKFTDHGCQHLCINTLGSYQC--------GCRAG 620

  Fly  1225 LQLRSNDNRICSGQLTLYDGPTTASNPIVIRCNGTIAKPLQSTGNRVLVRYDVGHDAPDGTDFML 1289
            .:|::| .:.|..                 .|.|.:                      |.|    
  Fly   621 YELQAN-GKTCED-----------------ACGGVV----------------------DAT---- 641

  Fly  1290 NYQTNCRVRLEGLQGAIETPNFPENYPPGQDCEWDIRAGGRKNH-LQLIFSHLSVE--KFS-SIC 1350
              ::|         |::.:|::|:.||..:.|.|::.|  ..|| :.|.|||..:|  :|. :.|
  Fly   642 --KSN---------GSLYSPSYPDVYPNSKQCVWEVVA--PPNHAVFLNFSHFDLEGTRFHYTKC 693

  Fly  1351 LNDYVSLVDMLDDQTLSEQHLCTNDGLEPITTVGNRLL-LRFKSDSSVELQGFRAEYKRIGCGEH 1414
            ..||:.:...:.|..|.:..:.....|.|:......:| |.|.||.:|:..||.|::. |...|.
  Fly   694 NYDYLIIYSKMRDNRLKKIGIYCGHELPPVVNSEQSILRLEFYSDRTVQRSGFVAKFV-IDVDEC 757

  Fly  1415 LRESGGRFESPNAPFSVDMDCVWIITASEGNQIRLLLHEVYFEAPQIECRDAESSLSVSAPSGYN 1479
            ...:||              |                        |..||:...|...|..:|| 
  Fly   758 SMNNGG--------------C------------------------QHRCRNTFGSYQCSCRNGY- 783

  Fly  1480 SSVVLFRSCHEETQTQTFTSPGNELVIRFVSSSAPSRKYFKASFVQVPASCGGYISASSGVLTTP 1544
               .|..:.|..|:|:                                  |...|:.|.|||.:|
  Fly   784 ---TLAENGHNCTETR----------------------------------CKFEITTSYGVLQSP 811

  Fly  1545 GFHNHQDSKNVANYTSNIECVWTVEVTNGYGIRPHFEQFNLTDSGNCSVSFVELTKLEPDNKEIF 1609
            .:..        :|..||.|.|..:...|:.|:..|..|.:.....|...:|             
  Fly   812 NYPE--------DYPRNIYCYWHFQTVLGHRIQLTFHDFEVESHQECIYDYV------------- 855

  Fly  1610 LEKTCGEDSPMIRIVHGRKLRVRFKSQAGTWGRFIMYFERQCGGRLSTGEGYLQSRLDEECSWLV 1674
                        .|..||      ...:.|.|.:       ||||    |.|             
  Fly   856 ------------AIYDGR------SENSSTLGIY-------CGGR----EPY------------- 878

  Fly  1675 TSPEGSKLSLIINQLECPKCNAVSQNCSEGLQLLNDDDQVLLYQMCRDHPANLIVPANNVRILTH 1739
                                 ||..:.:|...:|..|                           .
  Fly   879 ---------------------AVIASTNEMFMVLATD---------------------------A 895

  Fly  1740 GIRLQAQFSTFENSCGGNITSASGS---LSSPNYPD-SYPANIECVWSIRTRPGNALEITFEAMD 1800
            |::.:...:||.:.|||.:.:.:.|   .|.|.|.. .|..|:.|.|.|:..|.::::|.|...:
  Fly   896 GLQRKGFKATFVSECGGYLRATNHSQTFYSHPRYGSRPYKRNMYCDWRIQADPESSVKIRFLHFE 960

  Fly  1801 IVRSEHCNDDFLEI------RSSVQGPLLALYCDKNLPETPLVVHSE--LWIKFRSRPGNTAGGF 1857
            |..||.|:.|:|||      .:::.|    .:|.|:.|  |:::.:.  |.::|::...|:..||
  Fly   961 IEYSERCDYDYLEITEEGYSMNTIHG----RFCGKHKP--PIIISNSDTLLLRFQTDESNSLRGF 1019

  Fly  1858 RFRWTYVHNNEINSGINGTIEPPPPLFVSN 1887
            ...:..|...|.:.|.:.....|.|.::.:
  Fly  1020 AISFMAVDPPEDSVGEDFDAVTPFPGYLKS 1049

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Cubn2NP_729748.3 cubilin_NTD 38..141 CDD:412063
EGF_CA 156..190 CDD:238011
EGF_CA 192..233 CDD:238011
EGF_CA 290..328 CDD:214542
EGF_CA 330..374 CDD:214542
EGF 427..455 CDD:394967
EGF_CA 462..496 CDD:238011
CUB 503..619 CDD:238001
CUB 624..738 CDD:238001 11/65 (17%)
CUB 745..854 CDD:238001 21/115 (18%)
CUB 857..963 CDD:238001 15/106 (14%)
CUB 1066..1179 CDD:238001 41/113 (36%)
CUB 1185..1293 CDD:238001 15/108 (14%)
CUB 1303..1406 CDD:238001 32/107 (30%)
CUB 1411..1523 CDD:238001 15/111 (14%)
CUB 1530..1648 CDD:238001 23/117 (20%)
CUB 1754..1862 CDD:238001 33/119 (28%)
CUB 1979..2091 CDD:238001
CUB 2210..2321 CDD:238001
CUB 2327..2441 CDD:238001
CUB 2688..2782 CDD:412131
CUB 2810..2911 CDD:238001
CUB 3029..3143 CDD:238001
CUB 3169..3249 CDD:412131
CUB 3499..3607 CDD:238001
tldNP_524487.2 ZnMc_BMP1_TLD 137..338 CDD:239808 33/175 (19%)
CUB 388..474 CDD:214483 18/93 (19%)
CUB 478..586 CDD:395345 41/117 (35%)
FXa_inhibition 595..630 CDD:464251 10/43 (23%)
CUB 634..750 CDD:395345 37/154 (24%)
FXa_inhibition 757..792 CDD:464251 12/76 (16%)
CUB 797..906 CDD:395345 35/219 (16%)
CUB 910..1023 CDD:395345 33/118 (28%)
Blue background indicates that the domain is not in the aligned region.

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