Protein Alignment Cubn2 and tok

DIOPT Version :10

• Sequence 1: NP_729748.3
• Gene: Cubn2 / 39334
• FlyBaseID: FBgn0259140
• Length: 3613
• Species: Drosophila melanogaster
• Sequence 2: NP_476879.1
• Gene: tok / 42944
• FlyBaseID: FBgn0004885
• Length: 1464
• Species: Drosophila melanogaster
• Alignment Length: 901
• Identity: 220/901 - (24%)
• Similarity: 353/901 - (39%)
• Gaps: 234/901 - (25%)

  Fly   923 DQKRHIVKSTDNLI--------LLSHSNRASLVFHGSGGGRGMRLEYNFVPNQCGGFLNEPGRRY 979
            |:::|:|...:|::        :||.....||         ||..:|:.:.:....
  Fly   630 DREKHVVIEHNNIMKGQDYNFNMLSPDEVDSL---------GMAYDYDSIMHYARN--------- 676

  Fly   980 VTAVRGTFCQWF--IDFPGRKKISIHTLGPTPSISIYDNSTSPGKLVNSYSGSVGDVFDGDLLTI 1042
             |..:||:....  |:..|||:         |.|                 |....:..||:...
  Fly   677 -TFSKGTYLDTILPIEMKGRKR---------PEI-----------------GQRLRLSQGDIAQA 714

  Fly  1043 NLHTNWPRLEIYSIQFDIVQQDSCGGTFTARFGYIKSPNWPKNY------GESQMCEWILRAPFG 1101
            ||....|:               ||.||....|...||:   :|      .|::.|||.:.|.:|
  Fly   715 NLLYKCPK---------------CGRTFQESSGIFASPS---HYTAGALSNETEHCEWRITATYG 761

  Fly  1102 HRIELVVHNFTLEEEYSSTGCWTDWLEIRNGDSESSPLIGRYCGNEIPSRIPSFGNVLHLKFKSD 1166
            .|:||.:.|..:   :.|..|.||:||||:|..|.||||||:||......|.:..:.:.|.:.:.
  Fly   762 ERVELKLENMNI---FKSNNCETDYLEIRDGYFEKSPLIGRFCGKVDKEVIRTESSRMLLTYVNT 823

  Fly  1167 DSMEE-KGFLLSWQQMGAGCGGKLS--SSMGTIHSPHLLAGNRGILACDWQIIVAEGSRVSLQLR 1228
            ..:|. :||...:..:   |||:||  .::|.:.||:..........|.|:|.|.|..:|:|:.:
  Fly   824 HRIEGFRGFKAEFDVV---CGGELSVDDAVGRLESPNYPLDYLPNKECVWKITVPESYQVALKFQ 885

  Fly  1229 S----NDNRICSGQLTLYDGPTTASNPIVIRCNGTIAKPLQSTGNRVLVRY-------DVGHDAP 1282
            |    |.:......:.:.|||...:..|.:.|.......::|:||.:.|::       ..|..|.
  Fly   886 SFEVENHDSCVYDYVEVRDGPGQDAPLIGVFCGYKPPPNMKSSGNSMYVKFVSDTSVQKAGFSAV 950

  Fly  1283 DGTDFM-----------------LN----YQTNCRVRLE-------------GL----QGAIETP 1309
                ||                 :|    |:.:||:..|             |:    .|.|.:|
  Fly   951 ----FMKEVDECETQNHGCEHECINTLGGYECSCRIGFELHSDKKHCEDACGGVIEYPNGTITSP 1011

  Fly  1310 NFPENYPPGQDCEWDIRAGGRKNHLQLIFSHLSVEKFS---SICLNDYVSLVDMLDDQTLSEQHL 1371
            :|||.||..::|.|:|.| ..|:.:.|.|:|..:|..:   |.|..|.|::...|.:..|.....
  Fly  1012 SFPEMYPLLKECIWEIVA-PPKHRISLNFTHFDLEGTAHQQSDCGYDSVTVYSKLGENRLKRIGT 1075

  Fly  1372 CTNDGLEP-ITTVGNRLLLRFKSDSSVELQGFRAEY---------KRIGC--------------- 1411
            .....:.| .|:..|.|.|.|.||.|::..||.|.:         ...||
  Fly  1076 FCGSSIPPTATSESNALRLEFHSDKSIQRSGFAAVFFTDIDECAVNNGGCQHECRNTIGSYICMC 1140

  Fly  1412 --GEHLRESG----------------GRFESPNAP--FSVDMDCVWIITASEGNQIRLLLHEVYF 1456
              |..:.|:|                |...|||.|  :..:.||||....:.|::|:|:.:|...
  Fly  1141 HNGYSMHENGHDCKEGECKYEISAPFGTIFSPNYPDSYPPNADCVWHFITTPGHRIKLIFNEFDV 1205

  Fly  1457 EAPQIECR-------DAESSLSVSAPSGYNSSVVLFRSCHEETQTQTFTSPGNELVIRFVSSSAP 1514
            |:.| ||.       |.||          .||.||.|.|.::... ..:|..|::.:...:....
  Fly  1206 ESHQ-ECTYDNVAVYDGES----------ESSSVLGRFCGDKIPF-PISSTSNQMYMVLKTDKNK 1258

  Fly  1515 SRKYFKASFVQVPASCGGYISASSGVLTTPGFHNHQDSKNVANYTSNIECVWTVEVTNGYGIRPH 1579
            .:..|.||.   ..:||||:.|:|.|   ..|::|....| .:|...::|.||:...:...::..
  Fly  1259 QKNGFTASH---STACGGYLRATSQV---QQFYSHARFGN-QDYDDGMDCEWTIAAPDNSYVQLI 1316

  Fly  1580 FEQFNLTDSGNCSVSFVELTKLEPDNKEIFLE------KTCGEDSPMIRIVHGRKLRVRFKSQAG 1638
            |..|::..|.||:..:|::..   |..:::.:      :.||...|.........|.||||
  Fly  1317 FLTFDIESSENCTFDYVQVFS---DIDDVYGQYGPMYGQYCGNVLPQDINSMTHSLLVRFK---- 1374

  Fly  1639 TWGRFIMY-FERQCGGRLSTGEGYLQSRLDEECSW---LVTSPEGSKLSLIINQLE 1690
            |.|...|. |........::|| |..|..|.|.|:   :||...||..|:.|...:
  Fly  1375 TDGSVPMKGFSASYVAVPNSGE-YDHSDEDVENSYSSEMVTPFPGSLKSIYIEDTQ 1429

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cubn2	NP_729748.3	cubilin_NTD	38..141	CDD:412063
		EGF_CA	156..190	CDD:238011
		EGF_CA	192..233	CDD:238011
		EGF_CA	290..328	CDD:214542
		EGF_CA	330..374	CDD:214542
		EGF	427..455	CDD:394967
		EGF_CA	462..496	CDD:238011
		CUB	503..619	CDD:238001
		CUB	624..738	CDD:238001
		CUB	745..854	CDD:238001
		CUB	857..963	CDD:238001	11/47 (23%)
		CUB	1066..1179	CDD:238001	41/119 (34%)
		CUB	1185..1293	CDD:238001	32/141 (23%)
		CUB	1303..1406	CDD:238001	35/106 (33%)
		CUB	1411..1523	CDD:238001	34/153 (22%)
		CUB	1530..1648	CDD:238001	32/124 (26%)
		CUB	1754..1862	CDD:238001
		CUB	1979..2091	CDD:238001
		CUB	2210..2321	CDD:238001
		CUB	2327..2441	CDD:238001
		CUB	2688..2782	CDD:412131
		CUB	2810..2911	CDD:238001
		CUB	3029..3143	CDD:238001
		CUB	3169..3249	CDD:412131
		CUB	3499..3607	CDD:238001
tok	NP_476879.1	ZnMc_BMP1_TLD	520..721	CDD:239808	25/135 (19%)
		CUB	723..836	CDD:412131	41/118 (35%)
		CUB	840..951	CDD:395345	28/114 (25%)
		FXa_inhibition	958..993	CDD:464251	5/34 (15%)
		CUB	997..1111	CDD:395345	36/114 (32%)
		FXa_inhibition	1118..1153	CDD:464251	5/34 (15%)
		CUB	1158..1267	CDD:395345	30/120 (25%)
		CUB	1271..1390	CDD:238001	33/129 (26%)