DRSC/TRiP Functional Genomics Resources

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Protein Alignment Cubn2 and CG42613

DIOPT Version :10

Sequence 1:NP_729748.3 Gene:Cubn2 / 39334 FlyBaseID:FBgn0259140 Length:3613 Species:Drosophila melanogaster
Sequence 2:NP_001247185.1 Gene:CG42613 / 42269 FlyBaseID:FBgn0261262 Length:1188 Species:Drosophila melanogaster


Alignment Length:1132 Identity:222/1132 - (19%)
Similarity:361/1132 - (31%) Gaps:390/1132 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly   278 NVTSASPSACVRDVDECEPRVNPCHDECINLPGSFRCGACPTGYTGDGRFCRDIDECASEDNGGC 342
            |..:...|...|...:.:...|.|:  ||:          ...:..|...|....:..||     
  Fly    11 NTPTTISSTTTRQPLQQQQHTNNCN--CIS----------RKQFQNDTFLCHTQTQSESE----- 58

  Fly   343 SLQPRVTCTNTEGSHRCGR--CPAGWTGDGRTCTASDSNSCNNEGICHPLAKCEYVSDMVVCTCP 405
                ..|.|.|..:..|..  ..|..:..|.|.||:.::                  |:....||
  Fly    59 ----AATATTTAAATLCQSTLAAAATSATGTTATAAATD------------------DVPASECP 101

  Fly   406 LGSFGHGYGADGCSADSSRLPCDQHPCQNNGTCVQNGRGTTCI------------CQPGYSGVVC 458
                 ..:..|. ::||.|  ..||..:|....:..||....:            ..|..:....
  Fly   102 -----QSWTTDE-NSDSDR--DTQHRMRNPLDDIAAGRNVAVLPVVQQQQDLADTAAPLVASTGI 158

  Fly   459 NSSDACHPSPCLNGGTCRLLPDAKYQ----------------CVCPRGYTGTTCSHQRF----FC 503
            :..|....|.||:..:.::..|:..|                ........|.....|:|    |.
  Fly   159 SEQDRLATSTCLSRLSSKVSQDSTKQQRKLYQHGEATKDYAAAASTTPAVGILTDMQKFARSIFP 223

  Fly   504 GVTIRG--P---SGQLHYPPNTADGD-------------------------------------YQ 526
            .|.|..  |   :|..|...|.|||:                                     :.
  Fly   224 LVIIFNLLPLFYAGGAHLKSNGADGEPWMQPVVAYLEVSSRPTKSPKCDQTFVSRIGGPQNGSFS 288

  Fly   527 A---------DERCPFIIRTNRNMVLNLTFTQFQLEDS----------ADCTADFLQLHD----- 567
            |         ..:|.:.........:.:.|..|.|..|          ..|..:::.::.     
  Fly   289 APLLHNHRNHSRQCLYTFLAGPGQRVEVVFKSFNLRGSPPDGSAVGELPSCVHEYMDIYSEVQSS 353

  Fly   568 --GNSLSSRLIGRFCGSRLPMTNGSVITTQEQVFF------------WFRSDNQTQGKGFHVIWN 618
              ...::|...||:||:..|....|:.......||            .||..|.::   :.:   
  Fly   354 EPAELINSPFGGRYCGTIPPRRRISMYRAVAISFFSNKNVTTDLFEGTFRFINASE---YEI--- 412

  Fly   619 SLPFS---CGETI--NLTSTQTGVLRSPGYPGQARPELDCRWQLTAPFGYRLLLRF--YDISLGS 676
            .:|.:   |..||  :::..:||.|.||.|||....::.|.:|.......|:.|.|  :|:..|.
  Fly   413 GIPIAGSPCSYTITPSMSVNKTGALISPTYPGAYPKDMSCTYQFLGESNQRVRLEFRDFDLFFGG 477

  Fly   677 SEASAGNCSQDSLIVYD----SDRQLLRACQSIQPPPVYSSSNSLRLDFHTDAIRSDSSFQMHYE 737
            .     :|..|.:.|||    |...:...|...:...:|||.:||.:.|:|.:..::        
  Fly   478 P-----HCPFDYVKVYDGPDNSSALIGTYCGQQRNLVLYSSESSLFVHFYTLSRTAN-------- 529

  Fly   738 VVPGHPGCGGVYTESRGRISGYMNFEVCLYLIEQPRGTQVKLVIDRVSLVQSLSCHYLKIEIFDG 802
                        |::|| ..|...|                            |..::|::..  
  Fly   530 ------------TQNRG-FKGIYEF----------------------------SESFVKLDFI-- 551

  Fly   803 RSTDAPLLRRICGSHEESELEPIISIGNVILVRYEYALSGVRLSKSFDLTYTRVCTGNFNTNSGI 867
            |..|...:|   ||..:.::                      |||              ..::|.
  Fly   552 RENDGIHIR---GSECDQKI----------------------LSK--------------KESTGF 577

  Fly   868 ISTPNYPGPYFDDMTCTYNLTGPLDT----AVRMRITDLSLGTANNENDT------SYLDVYLSA 922
            :.:||||.||.....|.|.:.|..|.    .||:.....::....:::.:      .||.:||..
  Fly   578 VLSPNYPYPYIPKTVCRYFIYGMQDAQHLERVRLEFNAFNIPKVEHKDKSESNCTDGYLKIYLKG 642

  Fly   923 DQKRHIVKSTDNLI-------LLSHSNRASLVF-HGSGGGRGMRLEYNF-----VPNQCG----- 969
            .:........|..:       ::|...|.::|| .|...|||.:.:|.|     :|....     
  Fly   643 QETADAYDKFDYELCGNETQRVISEGPRLAMVFSSGELQGRGFKGKYTFETEYKIPGTAAPDGTC 707

  Fly   970 -----------GFLNEPGRRYVTAV-RGTFCQWFIDFPGRKKISI---H-----------TLGPT 1008
                       |.||.|  ||.:.. ..|.|.:.......::::|   |           |.|..
  Fly   708 SFTYVSSSKKRGELNSP--RYPSNYPSDTNCSYLFLAEADEQVTIVFDHFKIKADNNANATAGAY 770

  Fly  1009 PS-------ISIY----DNS----------TSPGKLVNSYSGSVGDVFDGDLLTINLHTNWPRLE 1052
            .|       :.:|    ||:          |:||. |.|..|:||       |.|.|||:..   
  Fly   771 GSGACFEDWLEMYVVYRDNNDRLLGRYCGQTAPGP-VESPRGAVG-------LRITLHTDQE--- 824

  Fly  1053 IYSIQ--------FDIVQQDS--CGGTFTAR-FGYIKSPNWPKNYG------ESQMCEWILRAPF 1100
              |:.        |:..:.|:  |||.|:.: .|.|.|||||..|.      .|..|.|:::|..
  Fly   825 --SVASGFKARYFFESAKSDAGDCGGNFSNQDSGLITSPNWPAGYKAPGRGMASNACNWVMKARP 887

  Fly  1101 GHRIELVVHNFTLEEEYSSTGCWTDWLEI-RNGDSESSPLIGRYCGNEIPS---RIPSFGNVLHL 1161
            |:::.:....|.||.:.::.||....|.: .|.||:..||  ..||.:.|.   ...|.|....:
  Fly   888 GYKLSIHFEQFGLEGDPANRGCPAAVLRLWMNVDSDQPPL--ELCGEKPPVEQWHYTSTGQTARI 950

  Fly  1162 KF-KSDDSMEEKGFLLSW---QQMGAG 1184
            .| .||.::..:||.:.|   |..|.|
  Fly   951 SFTTSDKTVGAQGFRIVWTEIQDSGPG 977

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Cubn2NP_729748.3 cubilin_NTD 38..141 CDD:412063
EGF_CA 156..190 CDD:238011
EGF_CA 192..233 CDD:238011
EGF_CA 290..328 CDD:214542 5/37 (14%)
EGF_CA 330..374 CDD:214542 9/45 (20%)
EGF 427..455 CDD:394967 6/39 (15%)
EGF_CA 462..496 CDD:238011 7/49 (14%)
CUB 503..619 CDD:238001 28/195 (14%)
CUB 624..738 CDD:238001 32/121 (26%)
CUB 745..854 CDD:238001 15/108 (14%)
CUB 857..963 CDD:238001 27/123 (22%)
CUB 1066..1179 CDD:238001 39/127 (31%)
CUB 1185..1293 CDD:238001 222/1132 (20%)
CUB 1303..1406 CDD:238001
CUB 1411..1523 CDD:238001
CUB 1530..1648 CDD:238001
CUB 1754..1862 CDD:238001
CUB 1979..2091 CDD:238001
CUB 2210..2321 CDD:238001
CUB 2327..2441 CDD:238001
CUB 2688..2782 CDD:412131
CUB 2810..2911 CDD:238001
CUB 3029..3143 CDD:238001
CUB 3169..3249 CDD:412131
CUB 3499..3607 CDD:238001
CG42613NP_001247185.1 CUB 277..404 CDD:238001 17/126 (13%)
CUB 421..541 CDD:238001 36/145 (25%)
CUB 564..691 CDD:238001 30/162 (19%)
CUB 707..836 CDD:238001 30/143 (21%)
CUB 846..969 CDD:238001 38/124 (31%)
LDLa 987..1022 CDD:238060
Blue background indicates that the domain is not in the aligned region.

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