Protein Alignment Cubn2 and Nrx-IV

DIOPT Version :10

• Sequence 1: NP_729748.3
• Gene: Cubn2 / 39334
• FlyBaseID: FBgn0259140
• Length: 3613
• Species: Drosophila melanogaster
• Sequence 2: NP_524034.2
• Gene: Nrx-IV / 39387
• FlyBaseID: FBgn0013997
• Length: 1284
• Species: Drosophila melanogaster
• Alignment Length: 1211
• Identity: 230/1211 - (18%)
• Similarity: 379/1211 - (31%)
• Gaps: 432/1211 - (35%)

  Fly   570 SLSSRLIGRFCGSRLPMTNGSVITTQEQVFFWFRSDNQTQGKGFHVIWNSLPFSCGETI--NLTS 632
            :.||...|..|  .|.:.|..:.:.|...|..:.||                :.|.:.:  ....
  Fly    11 AFSSLQFGLLC--LLLLVNNGIKSVQADAFTDYFSD----------------YDCNQPLMERAVL 57

  Fly   633 TQTGVLRSPGYPGQARPELDCRW-QLTAPFGYRLLLRFYDISLGSSEASAGNCSQDS-----LIV 691
            |.|..|...| |.:||...:..| .:...:.:.|.|...|..:....|:.|....|.     ::.
  Fly    58 TATSSLTERG-PDKARLNGNAAWTPVENTYNHFLTLDLGDPRMVRKIATMGRMHTDEFVTEYIVQ 121

  Fly   692 YDSDRQLLRACQSIQPPPVYSSSNSLRLDFHTDAIRSDSSFQMHYEVVPGHPGCGGVYTESRGRI 756
            |..|.:..|:..:....|.....|            ||.: .:||.|
  Fly   122 YSDDGEFWRSYVNPTSEPQMFKGN------------SDGN-SIHYNV------------------ 155

  Fly   757 SGYMNFEVCLYL----IEQPRGTQVKLVIDRVSL-VQSLSCHYLKIEI-FDGRSTDAPLLRRICG 815
                 |||.:..    |...|..      ||:|: |:...|.|:...: |:|.......|||
  Fly   156 -----FEVPIIAQWVRINPTRWH------DRISMRVELYGCDYISENLYFNGTGLVRYDLRR--- 206

  Fly   816 SHEESELEPIISIGNVILVRYEYAL-SGVRLSKSFDLTYTRVCTGNFNTNSGIISTPNYPGPYFD 879
                   |||.|....|..|::.|. :||       :.|:|...|            :|......
  Fly   207 -------EPITSTKESIRFRFKTAFANGV-------MMYSRGTQG------------DYYALQLK 245

  Fly   880 DMTCTYNLTGPLDTAVRMRITDLSLGTANNENDTSYLDVYLSADQKRHIVKSTDNLILLSHSNRA 944
            |.....|    ||...|: :|.||:|:..::|  .:.||.:|.:| |.|:.|.|.:|:
  Fly   246 DNKMVLN----LDLGSRV-MTSLSVGSLLDDN--VWHDVVISRNQ-RDIIFSVDRVIV------- 295

  Fly   945 SLVFHGSGGGRGMRLEYN------FVPNQCGGFLNEPGRRYVTAVRGTFCQWFIDFPGRKKISIH 1003
                .|...|...||..|      .|||...|.:.:.                 :|.|..:
  Fly   296 ----RGRIQGEFTRLNLNRELYLGGVPNVQEGLIVQQ-----------------NFSGCLE---- 335

  Fly  1004 TLGPTPSISIYDNSTSPGKLVNSYSGSVGDVFDGDLLT-INLHTNWPRLEIYSIQFDIVQQDSCG 1067
                    :||.|||:..:::.. |..:|   :|.|.| :|.....|...||.:
  Fly   336 --------NIYFNSTNFIRVMKD-STELG---EGYLFTRVNTIYACPSPPIYPV----------- 377

  Fly  1068 GTFTARFGYIKSPNWPKNYGESQMCEWILRAPFGHRIELVVHNFTLEE-------EYSSTGCWTD 1125
             |||.|..:::.    |.|..||            |:.:..:..|.||       ::.|.|....
  Fly   378 -TFTTRSSFVRL----KGYENSQ------------RLNVSFYFRTYEETGVMLHHDFYSGGYLKV 425

  Fly  1126 WLEIRNGDSESSPLIGRYCGNEIPSRIPSFGNV-LHLKFKS---------DD------------S 1168
            :||                          ||.| :.||.|.         ||            |
  Fly   426 FLE--------------------------FGKVKIDLKVKDKARIILDNYDDQFNDGKWHSFVIS 464

  Fly  1169 MEEKGFLLSWQQMGAGCGGKLSSSMGTIHSPHLLAGNR---GILACDWQIIVAEGSRVSLQLRSN 1230
            :|:...:|:..|........:..:.|   :.:.:||.:   |.:.| .::|..:|:....|....
  Fly   465 IEKNRLILNIDQRPMTTTKSMQVATG---AQYYIAGGKDKNGFVGC-MRLISVDGNYKLPQDWVK 525

  Fly  1231 DNRICSGQLTLYDGPTTASNPIVIRCNGTIAKPLQSTG----NRVLVRYDVGHDAPDGTDFMLNY 1291
            ...:|.|...:.|     :..::.|||   ..|.|..|    |......|.||
  Fly   526 GEEVCCGDDVVVD-----ACQMIDRCN---PNPCQHKGLCHQNSREFFCDCGH------------ 570

  Fly  1292 QTNCRVRLEGLQGAI-ETPNFP---------ENYPPGQDCEWDIRAGGRKNHLQLIFSHLSVEKF 1346
                    .|..||: .|.|.|         ::.....:...|:...|            .:|.|
  Fly   571 --------TGYAGAVCHTSNNPLSCLALKNVQHVQQRVNLNLDVDGSG------------PLEPF 615

  Fly  1347 SSICLNDYVSLVDMLDDQTLSEQHLCTNDGL-EP------ITTVGNRL---LLRFKSDSSVELQG 1401
            ...|  ::.|...::...:.|::|..|.||. ||      |....|:|   .|..:|.|..:...
  Fly   616 PVTC--EFYSDGRVITTLSHSQEHTTTVDGFQEPGSFEQSIMYDANQLQIEALLNRSHSCWQRLS 678

  Fly  1402 FRAEYKRIGCGEHLRESGGRFESPN-----APFSVDMDCVWIITASEGNQIRLLLHEVYFEAPQI 1461
            :.....|:            |.||:     .|||      |.|  |..||            |.
  Fly   679 YSCRSSRL------------FNSPSEAGNFRPFS------WWI--SRHNQ------------PM- 710

  Fly  1462 ECRDAESSLSVSAPSGYNSSVVLFRSCHEETQ-------TQTFTSPGNEL---------VIRFVS 1510
                  ...:.:.|........:...||:.|:       :..:...|.::         .::|..
  Fly   711 ------DYWAGALPGSRKCECGILGKCHDPTKWCNCDSNSLEWMEDGGDIREKEYLPVRAVKFGD 769

  Fly  1511 SSAPSRKYFKASFVQVPASCGGYISASSGVLTTPGFHNHQDSKNVANYTSNIECVWTVEVTNGYG 1575
            :..|..:.. ..:...|..|.| ....|.|:|.          .:|:.:.|:
  Fly   770 TGTPLDEKM-GRYTLGPLRCEG-DDLFSNVVTF----------RIADASINL------------- 809

  Fly  1576 IRPHFEQFNLTDSGNCSVSFVELTKLEPDNKEIFLEKTCGEDSPMIRIVHGRKLRVRFKSQAGTW 1640
                 ..|::..||:..:.|    :...:|..|| ..|...|...:.:..|.||:.::::.:|..
  Fly   810 -----PPFDMGHSGDIYLEF----RTTQENSVIF-HATGPTDYIKLSLNGGNKLQFQYQAGSGPL 864

  Fly  1641 GRFIMYFERQCGGRLSTGEGYLQSRLDEECSWLVTSPEGSK 1681
            |             ::.|..|   .|::. :|...|.|.::
  Fly   865 G-------------VNVGTSY---HLNDN-NWHTVSVERNR 888

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cubn2	NP_729748.3	cubilin_NTD	38..141	CDD:412063
		EGF_CA	156..190	CDD:238011
		EGF_CA	192..233	CDD:238011
		EGF_CA	290..328	CDD:214542
		EGF_CA	330..374	CDD:214542
		EGF	427..455	CDD:394967
		EGF_CA	462..496	CDD:238011
		CUB	503..619	CDD:238001	10/48 (21%)
		CUB	624..738	CDD:238001	24/121 (20%)
		CUB	745..854	CDD:238001	25/115 (22%)
		CUB	857..963	CDD:238001	26/111 (23%)
		CUB	1066..1179	CDD:238001	27/141 (19%)
		CUB	1185..1293	CDD:238001	21/114 (18%)
		CUB	1303..1406	CDD:238001	24/122 (20%)
		CUB	1411..1523	CDD:238001	19/132 (14%)
		CUB	1530..1648	CDD:238001	21/117 (18%)
		CUB	1754..1862	CDD:238001
		CUB	1979..2091	CDD:238001
		CUB	2210..2321	CDD:238001
		CUB	2327..2441	CDD:238001
		CUB	2688..2782	CDD:412131
		CUB	2810..2911	CDD:238001
		CUB	3029..3143	CDD:238001
		CUB	3169..3249	CDD:412131
		CUB	3499..3607	CDD:238001
Nrx-IV	NP_524034.2	FA58C	57..184	CDD:238014	33/169 (20%)
		LamG	192..340	CDD:238058	50/224 (22%)
		LamG	376..514	CDD:238058	34/195 (17%)
		EGF	546..575	CDD:394967	10/51 (20%)
		LamG	819..943	CDD:214598	17/92 (18%)
		EGF_CA	966..998	CDD:238011
		Laminin_G_2	1032..1156	CDD:460494
		4.1m	1239..1255	CDD:128590