DRSC/TRiP Functional Genomics Resources

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Protein Alignment Cubn2 and JAG2

DIOPT Version :10

Sequence 1:NP_729748.3 Gene:Cubn2 / 39334 FlyBaseID:FBgn0259140 Length:3613 Species:Drosophila melanogaster
Sequence 2:NP_002217.3 Gene:JAG2 / 3714 HGNCID:6189 Length:1238 Species:Homo sapiens


Alignment Length:883 Identity:208/883 - (23%)
Similarity:288/883 - (32%) Gaps:359/883 - (40%)


- Green bases have known domain annotations that are detailed below.


  Fly   154 ARNECLSNPCKNGGTCHDAYKGFQCECPAGWQGDSCEDDVNECFT----LAGT---DLDG----- 206
            |.:.|.||||.|||:||:...||:|.||:||.|.:|..|::||.:    ..||   .:||     
Human   347 AEHACTSNPCANGGSCHEVPSGFECHCPSGWSGPTCALDIDECASNPCAAGGTCVDQVDGFECIC 411

  Fly   207 --------------------CLNNGQCINTPGSYRCVCRNGFTGTHCRLRHNTCLFGGSRELCGE 251
                                |||...|.|..|.|.|.|..|:.|.:|.:..|.|     |..|..
Human   412 PEQWVGATCQLDANECEGKPCLNAFSCKNLIGGYYCDCIPGWKGINCHINVNDC-----RGQCQH 471

  Fly   252 HGTCIQAANSAGYVCICDQGW----TWADANVTSASP------------------------SACV 288
            .|||....|  ||.|:|.:|:    ...:.:..::||                        ..|.
Human   472 GGTCKDLVN--GYQCVCPRGFGGRHCELERDECASSPCHSGGLCEDLADGFHCHCPQGFSGPLCE 534

  Fly   289 RDVDECEPRVNPCHD--ECINLPGSFRCGACPTGYTG----------DGRFCRDIDECASE---- 337
            .|||.|||  :||.:  .|.||.|.:.| |||..:.|          .|..||.||.|.|:    
Human   535 VDVDLCEP--SPCRNGARCYNLEGDYYC-ACPDDFGGKNCSVPREPCPGGACRVIDGCGSDAGPG 596

  Fly   338 -----------DNGGCSLQP-------------------------------RVTCTNTEGSHRCG 360
                       .:|.|..||                               ..||.:...:.|| 
Human   597 MPGTAASGVCGPHGRCVSQPGGNFSCICDSGFTGTYCHENIDDCLGQPCRNGGTCIDEVDAFRC- 660

  Fly   361 RCPAGWTGDGRTCTASDSNSCNNEGICHPLAKC-EYVSDMVVCTCPLGSFGHGYGADGCSADSSR 424
            .||:||  :|..|. ::.|.|..:. ||...:| :.|:|. .|.|       ..|..|.:..|..
Human   661 FCPSGW--EGELCD-TNPNDCLPDP-CHSRGRCYDLVNDF-YCAC-------DDGWKGKTCHSRE 713

  Fly   425 LPCDQHPCQNNGTCVQNGRGTTCICQPGYSGVVC----NSSDACHPSPCLNGGTCRLLPDAKYQC 485
            ..||.:.|.|.|||..:|....|.|.||:.|..|    |||  |.|:||:||||| :...|.:.|
Human   714 FQCDAYTCSNGGTCYDSGDTFRCACPPGWKGSTCAVAKNSS--CLPNPCVNGGTC-VGSGASFSC 775

  Fly   486 VCPRGYTGTTCSHQRFFCGVTIRGPSGQLHYPPNTADGDYQADERCPFIIRTNRNMVLNLTFTQF 550
            :|..|:.|.||:|                                       |.|          
Human   776 ICRDGWEGRTCTH---------------------------------------NTN---------- 791

  Fly   551 QLEDSADCTADFLQLHDGNSLSSRLIGRFCGSRLPMTNGSVITTQEQVFFWFRSDNQTQGKGFHV 615
                  ||                       :.||..||.:......   |||.:          
Human   792 ------DC-----------------------NPLPCYNGGICVDGVN---WFRCE---------- 814

  Fly   616 IWNSLPFSCGE--TINLTSTQTGVLRSP------------GY-----PGQARPELDCR------- 654
               ..|...|.  .||:...|:    ||            ||     ||:|.|.  |:       
Human   815 ---CAPGFAGPDCRINIDECQS----SPCAYGATCVDEINGYRCSCPPGRAGPR--CQEVIGFGR 870

  Fly   655 --WQLTAPFGY-----------RLLLRFYDIS-----------LGSSEASAGNCSQDSLIVYDSD 695
              |....||.:           |.|....|.|           .|..||.:..|......:..:.
Human   871 SCWSRGTPFPHGSSWVEDCNSCRCLDGRRDCSKVWCGWKPCLLAGQPEALSAQCPLGQRCLEKAP 935

  Fly   696 RQLLR-------ACQSIQPPPV-------YSSSNSLRLDFHTDAIRSDSSFQMHYEVVPGHPG-- 744
            .|.||       .|.:.:||..       :..:|..||..|           .:.:.||  .|  
Human   936 GQCLRPPCEAWGECGAEEPPSTPCLPRSGHLDNNCARLTLH-----------FNRDHVP--QGTT 987

  Fly   745 ----CGGVYT------ESRGRI---------SGYMNFEVCL-----------YLIEQPRGTQVKL 779
                |.|:.:      .:|.|:         ||....||.:           .||:......|..
Human   988 VGAICSGIRSLPATRAVARDRLLVLLCDRASSGASAVEVAVSFSPARDLPDSSLIQGAAHAIVAA 1052

  Fly   780 VIDRVSLVQSLSCHYLKIE-IFDGRSTDAPLLRRICGS 816
            :..|.:....|:...:|:| :..|.|:...|:..:||:
Human  1053 ITQRGNSSLLLAVTEVKVETVVTGGSSTGLLVPVLCGA 1090

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Cubn2NP_729748.3 cubilin_NTD 38..141 CDD:412063
EGF_CA 156..190 CDD:238011 18/33 (55%)
EGF_CA 192..233 CDD:238011 18/72 (25%)
EGF_CA 290..328 CDD:214542 18/49 (37%)
EGF_CA 330..374 CDD:214542 17/89 (19%)
EGF 427..455 CDD:394967 12/27 (44%)
EGF_CA 462..496 CDD:238011 14/33 (42%)
CUB 503..619 CDD:238001 11/115 (10%)
CUB 624..738 CDD:238001 34/177 (19%)
CUB 745..854 CDD:238001 20/99 (20%)
CUB 857..963 CDD:238001
CUB 1066..1179 CDD:238001
CUB 1185..1293 CDD:238001
CUB 1303..1406 CDD:238001
CUB 1411..1523 CDD:238001
CUB 1530..1648 CDD:238001
CUB 1754..1862 CDD:238001
CUB 1979..2091 CDD:238001
CUB 2210..2321 CDD:238001
CUB 2327..2441 CDD:238001
CUB 2688..2782 CDD:412131
CUB 2810..2911 CDD:238001
CUB 3029..3143 CDD:238001
CUB 3169..3249 CDD:412131
CUB 3499..3607 CDD:238001
JAG2NP_002217.3 MNNL 28..196 CDD:462222
DSL 178..240 CDD:128366
EGF_CA 307..345 CDD:238011
EGF 351..381 CDD:394967 18/29 (62%)
EGF_CA 385..421 CDD:238011 7/35 (20%)
EGF_CA 423..458 CDD:238011 11/34 (32%)
EGF_CA 461..496 CDD:238011 13/41 (32%)
EGF_CA 500..534 CDD:238011 2/33 (6%)
EGF_CA 536..571 CDD:238011 17/37 (46%)
EGF_CA 636..671 CDD:238011 9/37 (24%)
EGF_CA 676..709 CDD:238011 11/41 (27%)
EGF 716..746 CDD:394967 13/29 (45%)
EGF_CA 757..787 CDD:238011 14/30 (47%)
EGF_CA 789..824 CDD:238011 13/89 (15%)
EGF_CA 827..863 CDD:238011 10/41 (24%)
VWC_out 872..943 CDD:214565 14/70 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1114..1139
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1156..1238
Blue background indicates that the domain is not in the aligned region.

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