Protein Alignment Cubn2 and Tll2

DIOPT Version :10

• Sequence 1: NP_729748.3
• Gene: Cubn2 / 39334
• FlyBaseID: FBgn0259140
• Length: 3613
• Species: Drosophila melanogaster
• Sequence 2: NP_001178827.1
• Gene: Tll2 / 365460
• RGDID: 1559756
• Length: 1014
• Species: Rattus norvegicus
• Alignment Length: 1113
• Identity: 236/1113 - (21%)
• Similarity: 378/1113 - (33%)
• Gaps: 392/1113 - (35%)

  Fly   926 RHIVKST----------DNLILLSHSNRASLVFHGSGGGRGMRL-------EYNFVPNQCG---G 970
            ||..|.|          ::.|:.|:.......:.|..||....:       ::..|.::.|   |
  Rat   184 RHWEKHTCVTFIERTDEESFIVFSYRTCGCCSYVGRRGGGPQAISIGKNCDKFGIVAHELGHVVG 248

  Fly   971 FLNE---PGR-RYVTAVRGTFCQWFIDFPGRKKISIHTLGPTPSISIYDNSTSPGKLVNSYS--- 1028
            |.:|   |.| ::||.:|                               .:..||:..|...
  Rat   249 FWHEHTRPDRDQHVTIIR-------------------------------ENIQPGQEYNFLKMEA 282

  Fly  1029 ---GSVGDVFDGDLLT----------INLHTNWPRLEIYSI-----------QFDIVQQ------ 1063
               .|:|:.:|.|.:.          :.|.|..||.:...:           |.||.|.
  Rat   283 GEVSSLGETYDFDSIMHYARNTFSRGVFLDTILPRRDDNGVRPTIGQRVRLSQGDIAQARKLYKC 347

  Fly  1064 DSCGGTFTARFGYIKSPNWPKNYGESQMCEWILRAPFGHRIELVVHNFTLEEEYSSTGCWTDWLE 1128
            .:||.|.....|...:|.:|..|.....|.|.:....|.:|.|   |||..:.:.|..||.|::|
  Rat   348 PACGETLQDTSGNFSAPGFPNGYPSYSHCVWRISVTPGEKIIL---NFTSMDLFKSRLCWYDYVE 409

  Fly  1129 IRNGDSESSPLIGRYCGNEIPSRIPSFGNVLHLKFKSDDSMEEKGFLLSWQQMGAGCGGKLSSSM 1193
            ||:|....:||:||:||:::|..:.|..:.|.::|:|..|:..|||...::.|   |||
  Rat   410 IRDGYWRKAPLLGRFCGDKVPEPLVSSDSRLWVEFRSSSSILGKGFFAVYEAM---CGG------ 465

  Fly  1194 GTIHSPHLLAGNRGILACDWQIIVAEGSRVSLQLRSNDNRICSGQLTLYDGPTTASNPIVIRCNG 1258
                                                                             
  Rat   466 ----------------------------------------------------------------- 465

  Fly  1259 TIAKPLQSTGNRVLVRYDVGHDAPDGTDFMLNYQTNCRVRLEGLQGAIETPNFPENYPPGQDCEW 1323
                             |:..||                      |.|::||:|::|.|.::|.|
  Rat   466 -----------------DITKDA----------------------GQIQSPNYPDDYRPSKECVW 491

  Fly  1324 DIR-AGGRKNHLQLIFSHLSVEKFSSICLNDYVSLVDMLDDQTLSEQHLCTNDGLEPITTVGNRL 1387
            .|. |.|  .|:.|.|....:|:..| |..||:.:.|...:::....|.|..:..|.:.:..|||
  Rat   492 RITVADG--FHVGLTFQSFEIERHDS-CAYDYLEIRDGPTEESALIGHFCGYEKPEAVKSSANRL 553

  Fly  1388 LLRFKSDSSVELQGFRAEYKRIGCGEHLRESGGRFESPNAPFSVDMDCVWIITASEGNQIRLLLH 1452
            .::|.||.|:...||.|.:.:                     .|| :|.|   ...|.
  Rat   554 WVKFVSDGSINKAGFAASFFK---------------------EVD-ECSW---PDHGG------- 586

  Fly  1453 EVYFEAPQIECRDAESSLSVSAPSGYNSSVVLFRSCHEETQTQTFTSPGNELVIRFVSSSAPSRK 1517
                      |...    .|:....|..      :|          .||.||        |.::|
  Rat   587 ----------CEQR----CVNTLGSYTC------AC----------DPGYEL--------AANKK 613

  Fly  1518 YFKASFVQVPASCGGYISASSGVLTTPGFHNHQDSKNVANYTSNIECVWTVEVTNGYGIRPHFEQ 1582
                   ....:|||:|:..:|.:|:||:..        .|.:|..|||.|.....|.|...||.
  Rat   614 -------TCEVACGGFITKLNGTITSPGWPK--------EYPTNKNCVWQVVAPMQYRISLQFEA 663

  Fly  1583 FNLTDSGNCSVSFVEL-TKLEPDNKEIFLEKTCGEDSPMIRIVHGRKLRVRFKSQAGTWGRFIMY 1646
            |.|..:..|...|||: :.|.||.|  ...|.||.::|.:.......:||.|||..
  Rat   664 FELEGNDVCKYDFVEVRSGLSPDAK--LHGKFCGSETPEVITSQSNNMRVEFKSDN--------- 717

  Fly  1647 FERQCGGRLSTGEGYLQSRLDEECSWLVTSPEGSKLSLIINQLECPKCNAVSQNCSEGLQLLNDD 1711
                                       ..|..|.:.....::.||.|.|.   .|.:  :.:|..
  Rat   718 ---------------------------TVSKRGFRAHFFSDKDECAKDNG---GCQQ--ECVNTF 750

  Fly  1712 DQVLLYQMCRDHPANLIVPANNVRILTHGIRLQAQFSTFENSCGGNITSASGSLSSPNYPDSYPA 1776
            ...|.  .||          |..|:..:|      ....|..|...|:||.|:|.|||:||.||:
  Rat   751 GSYLC--RCR----------NGYRLHENG------HDCKEAGCAYKISSAEGTLMSPNWPDKYPS 797

  Fly  1777 NIECVWSIRTRPGNALEITFEAMDIVRSEHCNDDFLEIRSSV--QGPLLALYCDKNLPETPLVVH 1839
            ..||.|:|.:..|:.::|||...::.:.:.|..|.||:....  ..|:|..:|....|:..:...
  Rat   798 RKECTWNISSTAGHRVKITFSEFEVEQHQECAYDHLELYDGTDSSAPILGRFCGSKKPDPVVATG 862

  Fly  1840 SELWIKFRSRPGNTAGGFRFRWTYVHNNEINSGINGTIEPPPPLFVSNE--DQPFTWRLFTDFK- 1901
            |.|:::|.|.......||:    .||:.|....:...:: ...|:...:  |..:..:...|:.
  Rat   863 SSLFLRFYSDASVQRKGFQ----AVHSTECGGRLKAEVQ-TKELYSHAQFGDNNYPSQAHCDWVI 922

  Fly  1902 ------------KVFVLQFE-----EYISGLILFDGYDDNALAVNIPVSPWRFTSSSNVVYLKTV 1949
                        :.|.::.|     :|:..   :||||.:|..:.      ||..|..:..:.:.
  Rat   923 VAEDGYGVELVFRTFEVEEEADCGYDYLEA---YDGYDSSAPRLG------RFCGSGPLEEIYSA 978

  Fly  1950 NDAL-THF 1956
            .|:| .||
  Rat   979 GDSLMIHF 986

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cubn2	NP_729748.3	cubilin_NTD	38..141	CDD:412063
		EGF_CA	156..190	CDD:238011
		EGF_CA	192..233	CDD:238011
		EGF_CA	290..328	CDD:214542
		EGF_CA	330..374	CDD:214542
		EGF	427..455	CDD:394967
		EGF_CA	462..496	CDD:238011
		CUB	503..619	CDD:238001
		CUB	624..738	CDD:238001
		CUB	745..854	CDD:238001
		CUB	857..963	CDD:238001	9/53 (17%)
		CUB	1066..1179	CDD:238001	38/112 (34%)
		CUB	1185..1293	CDD:238001	6/107 (6%)
		CUB	1303..1406	CDD:238001	34/103 (33%)
		CUB	1411..1523	CDD:238001	15/111 (14%)
		CUB	1530..1648	CDD:238001	37/118 (31%)
		CUB	1754..1862	CDD:238001	35/109 (32%)
		CUB	1979..2091	CDD:238001
		CUB	2210..2321	CDD:238001
		CUB	2327..2441	CDD:238001
		CUB	2688..2782	CDD:412131
		CUB	2810..2911	CDD:238001
		CUB	3029..3143	CDD:238001
		CUB	3169..3249	CDD:412131
		CUB	3499..3607	CDD:238001
Tll2	NP_001178827.1	ZnMc_BMP1_TLD	149..348	CDD:239808	34/194 (18%)
		CUB	350..459	CDD:395345	38/111 (34%)
		CUB	463..572	CDD:395345	40/221 (18%)
		FXa_inhibition	579..615	CDD:464251	13/90 (14%)
		CUB	619..728	CDD:395345	39/154 (25%)
		FXa_inhibition	735..770	CDD:464251	11/57 (19%)
		CUB	775..884	CDD:395345	35/112 (31%)
		CUB	888..1001	CDD:395345	18/109 (17%)