Protein Alignment Cubn2 and nrp1a

DIOPT Version :10

• Sequence 1: NP_729748.3
• Gene: Cubn2 / 39334
• FlyBaseID: FBgn0259140
• Length: 3613
• Species: Drosophila melanogaster
• Sequence 2: XP_073796200.1
• Gene: nrp1a / 353246
• ZFINID: ZDB-GENE-030519-2
• Length: 1015
• Species: Danio rerio
• Alignment Length: 940
• Identity: 194/940 - (20%)
• Similarity: 316/940 - (33%)
• Gaps: 321/940 - (34%)

  Fly   619 SLPFSCGETINLTSTQTGVLRSPGYPGQARPELDCRWQLTAPF-GYRLLLRF---YDISLGSSEA 679
            |:|..||:.|.:||  ...|.|||||....|...|.|.:|||. ..|:|:.|   :|:
Zfish   109 SVPDKCGDNIRITS--ANYLTSPGYPVSYYPSQKCIWVITAPGPNQRILINFNPHFDL------- 164

  Fly   680 SAGNCSQDSLIV---YDSDRQLL-RACQSIQPPPVYSSSNSLRLDFHTDAIRSDSSFQMHYEVVP 740
            ....|..|.:.|   .|.:.||: :.|..|.|.||.||.|.|.:.|.:|.....:.|.:.||:..
Zfish   165 EDRECKYDYVEVRDGVDENGQLVGKYCGKIAPSPVVSSGNQLFIKFVSDYETHGAGFSIRYEIFK 229

  Fly   741 GHPGCGGVYTESRGRISG------YMNFEVCLYLIEQPRGTQVKLVIDRVSL------VQSLSCH 793
            ..|.|...:|.|.|.|..      |.|...|.::|..|:.:::.|..:...|      ...:.|.
Zfish   230 TGPECSRNFTSSSGVIKSPGFPEKYPNNLDCTFMIFAPKMSEIVLEFESFELEPDTQPPAGVFCR 294

  Fly   794 YLKIEIFDGRSTDAPLLRRICGSHEESELEPIISIGNVILVRYEYALSGVRLSKSFDLTYTRVCT 858
            |.::||:||.....|.:.|.||.:....:                            ::||....
Zfish   295 YDRLEIWDGFPGVGPYIGRYCGQNTPGRI----------------------------ISYTGTLA 331

  Fly   859 GNFNTNSGIIS---TPNY-------PGPYFDDMTCTYNL---TGPLDTAVRMRITDLSLGTANNE 910
            ...||:|.|..   :.|:       |    ||..||..|   ||.:.:...|         |:::
Zfish   332 MTINTDSAIAKEGFSANFTVLERTVP----DDFDCTEPLGMETGEIHSDQIM---------ASSQ 383

  Fly   911 NDTSYLDVYLSADQKRHIVKSTDN-LILLSHSNRASLVFHGSGGGRGMRLEYNFVPNQCGGFLNE 974
            ...|:     ||::.|  :.:.:| ...|..:|:           ..::::..|:
Zfish   384 YSNSW-----SAERSR--LNNPENGWTPLEDTNK-----------EWIQVDLGFL---------- 420

  Fly   975 PGRRYVTAVRGTFCQWFIDFPGRKKISIH--------------TLGPTPSISIYDNSTSPGKLVN 1025
               |:|:|: ||  |..|....:||..:.              |:...|...::..:|:|..:|.
Zfish   421 ---RFVSAI-GT--QGAISQETKKKYYVKEYKVDVSSNGEDWITIKDGPKQKLFQGNTNPTDVVK 479

  Fly  1026 SYSGSVGDVFDGDLLTINLH---TNWP-----RLEIYSIQFDIVQQDSCGGTFTARFGYIKSPNW 1082
            :       .|....||..|.   .||.     |.|:|..:   :.:..|.|......|.|.
Zfish   480 A-------KFPKPTLTRYLRIRPINWETGIALRFEVYGCK---ISEYPCSGMLGMVSGLIT---- 530

  Fly  1083 PKNYGESQMCEWILRAPFGHRIELVVHNFTLEEEYSSTGCWTDWLEIRNGDSESSPLIGRYCG-N 1146
                 :||:                    |:......|     |:      ||::.|:....| .
Zfish   531 -----DSQI--------------------TVSSHIERT-----WV------SENARLMTSRSGWM 559

  Fly  1147 EIPSRIPSFGNVLHLKFKSDDSMEE---KGFLLSWQQMGAGCGGKLSSSMGTIHSPHLLAGNRGI 1208
            .:|...|.....|.:     |..||   ||.::.        |||...:...:....|...|.|
Zfish   560 LLPQSQPYADEWLQI-----DLAEEKLVKGLIIQ--------GGKHRDNKVFMKKFRLGYSNNG- 610

  Fly  1209 LACDWQIIVAEGSRVSLQLRSNDNRICSGQLTLYDGPTTAS-NPIVIRCNGTIAKPLQSTGNRVL 1272
              .||:::        :....|..:|..|.|. ||.|...: .|::.|                .
Zfish   611 --SDWKLV--------MDATGNKPKIFEGNLN-YDTPALRTMEPVLTR----------------F 648

  Fly  1273 VRYDVGHDAPDGTDFMLNYQTNCRVRLEGLQGAIETPNFPENYP-----PGQDCEWDIRAGGRKN 1332
            ||.......|.|..          :|||.|...:|.|..|...|     |..:|:.|
Zfish   649 VRIYPDRGTPAGMG----------LRLELLGCEMEVPTVPPTTPAASTTPSDECDDD-------- 695

  Fly  1333 HLQLIFSHLSVEKFSSICL----NDYVSLVDMLDDQTLSEQHLCTNDGLEPITTV-GNRLLLRFK 1392
                          .:.|.    :||    |.....|.:|.       :..::|: |.:..|.|.
Zfish   696 --------------QANCHSGTGDDY----DQTGGTTATET-------IREMSTIPGEKAFLWFA 735

  Fly  1393 SDSS-----------VELQGFRAEYKRIG-----CGEHLRESGGRFESPNAPFSVDMDCVWIITA 1441
            .|..           .|..|||.:.:..|     .|.::..:||   |.|..::       :.|.
Zfish   736 CDFGWANDPSFCGWISEDSGFRWQIQSSGTPTLNTGPNMDHTGG---SGNFIYT-------LATG 790

  Fly  1442 SEGNQIRLLLHEVYFEAPQIECRDAESSLS 1471
            ::..::..|:      :|.:..:|::..||
Zfish   791 AQETEVARLV------SPSVSGQDSDLCLS 814

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cubn2	NP_729748.3	cubilin_NTD	38..141	CDD:412063
		EGF_CA	156..190	CDD:238011
		EGF_CA	192..233	CDD:238011
		EGF_CA	290..328	CDD:214542
		EGF_CA	330..374	CDD:214542
		EGF	427..455	CDD:394967
		EGF_CA	462..496	CDD:238011
		CUB	503..619	CDD:238001	194/940 (21%)
		CUB	624..738	CDD:238001	40/121 (33%)
		CUB	745..854	CDD:238001	22/120 (18%)
		CUB	857..963	CDD:238001	22/119 (18%)
		CUB	1066..1179	CDD:238001	21/116 (18%)
		CUB	1185..1293	CDD:238001	21/108 (19%)
		CUB	1303..1406	CDD:238001	22/123 (18%)
		CUB	1411..1523	CDD:238001	11/61 (18%)
		CUB	1530..1648	CDD:238001
		CUB	1754..1862	CDD:238001
		CUB	1979..2091	CDD:238001
		CUB	2210..2321	CDD:238001
		CUB	2327..2441	CDD:238001
		CUB	2688..2782	CDD:412131
		CUB	2810..2911	CDD:238001
		CUB	3029..3143	CDD:238001
		CUB	3169..3249	CDD:412131
		CUB	3499..3607	CDD:238001
nrp1a	XP_073796200.1	None