DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42255 and mep1bb

DIOPT Version :9

Sequence 1:	NP_729748.3	Gene:	CG42255 / 39334	FlyBaseID:	FBgn0259140	Length:	3613	Species:	Drosophila melanogaster
Sequence 2:	XP_009294699.1	Gene:	mep1bb / 327586	ZFINID:	ZDB-GENE-030131-5797	Length:	774	Species:	Danio rerio

Alignment Length:	778	Identity:	146/778 - (18%)
Similarity:	237/778 - (30%)	Gaps:	251/778 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly  1024 VNSYSGSVGDVFDGDLL---------TINLHTNWPRLEIYSIQFDIVQQDSCGGTFTARFGY--- 1076
            ||..:|.  |:|:||:|         .|.....||:...|..:.|:  :.:..|.....|..
Zfish    52 VNEDAGL--DLFEGDILYDETLGRNSIIGEEYRWPKTIPYYFEDDL--EINAKGVILKAFEQYRL 112

  Fly  1077 ---IKSPNW--PKNY-------------GESQMCEWILRAPFG-HRIELVVHNFTLEEEYSSTGC 1122
               |....|  .:||             |..::....|....| .||..:.|.|     ..:.|.
Zfish   113 KTCIDYKPWTGEENYISVFKGNGCFSSVGNRRVGRQTLSIGSGCDRIATIEHEF-----LHALGF 172

  Fly  1123 WTD-------------WLEIRNG---------DSESSPLIGRY--------------CGNE--IP 1149
            |.:             |..|..|         ||.||.|...|              .|:|  |.
Zfish   173 WHEQSRSDRDDYVSIMWDRITEGKEHNFNKYNDSSSSALNVPYDYSSMMHYSQKAFQSGSEPTII 237

  Fly  1150 SRIPSFGNVLHLKFKSDDS------------------------------MEEKG---FLLSWQQM 1181
            :|||:|.:|:..:.:..||                              |.:||   ....|:::
Zfish   238 TRIPAFSSVIGQRMEFSDSDLLKLNRLYNCTSSSTFLDSCDFELENICGMIQKGEADSTAEWRRV 302

  Fly  1182 GAGCGGKLS--SSMG------------TIHSPHLLAGNRGILACDWQIIVAEGSRVSLQLRSNDN 1232
            ....||..:  ::||            |...|.   |.:.:|  :.:::..:.....||....::
Zfish   303 PEAAGGPDTDYTNMGRCEGKGYFMHFSTAGGPE---GAKALL--ESRVLYPKRGFQCLQFFVFNS 362

  Fly  1233 RICSGQLTLYDGPTTASNPIVIRCNGTI-------AKPLQSTGNRVLVRYDVGHDAPDGTDFMLN 1290
            ...|.:|.::.......||     |||:       |.|.:        |:.:.|       ..||
Zfish   363 GHTSDRLRIWTREFDTENP-----NGTLRLVQQIHAPPGE--------RWQLQH-------ISLN 407

  Fly  1291 YQTNCRVRLEGLQG-------AIETPNFPENYPPGQDCEWDIRAGGRKNHLQLIFSHLSVEKFSS 1348
            .....||..||.:|       :|:..|..|...|  |..|.:|                  .|.|
Zfish   408 VSRKFRVVFEGTKGTGSSGGLSIDDINLSETRCP--DHVWIVR------------------DFKS 452

  Fly  1349 ICLNDYVSLVDMLDDQTLSEQHLCTNDGLEPITTVGNRLLLRFKSDSSVELQGFRAEYKRIGCGE 1413
            |..|..:... :...:..|........||.|..|.||              .|....|..:..|:
Zfish   453 ILENTPMDTA-IYSPRFTSRLGYSFQMGLYPNGTAGN--------------PGEMGAYAHLVSGD 502

  Fly  1414 HLRESGGRFESPNAPFSVDMDCVWIITASEGNQIRLLLHEVYFEAPQIECR-DAESSLSVSAPSG 1477
                           .:||...||   .::..|:.:::.:   :...|..| ..:.|::......
Zfish   503 ---------------AAVDGGLVW---PAQWKQMTMMMMD---QNADIRRRMSNQRSVTTDPNMT 546

  Fly  1478 YNSSVVLF--------RSCHEETQTQTFTSPGNELVIRFVSSSAPSRKYFK---ASFVQVPASCG 1531
            ...|:.||        ....::..|:.|..||....:....:.|.||.:.|   |.|:.......
Zfish   547 VEGSLNLFWDDPRKVGVKVTDDNGTEYFRGPGAGTPVYLTQARALSRDFIKGGDAIFLLTMEDIS 611

  Fly  1532 GYISAS--SGVLTTPGFHNHQDSKNVANYTSNIECVWTVEVTNGYGIRPHFEQFNLTDSGNCSVS 1594
            ..:::.  .....||....|....|..|.|:......|..:|       |......|.|...|.|
Zfish   612 DLVASQPLPSTTVTPATSAHTGPTNPDNSTTASPATHTSSIT-------HTSADTHTSSSTTSSS 669

  Fly  1595 FVELTKLEPDNKEIFLEKTCGEDSPMIRIVHGRKLRVRFKSQAGTWGRFIMYFERQCGGRLST 1657
              ..|.:.|.:..:.|:  |..|...::...|:.: .|....:..|     |:..:|..:.||
Zfish   670 --SSTTVPPPDPCVSLQ--CENDGVCVQDDAGQPV-CRCAVGSDWW-----YYGERCQHKSST 722

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42255	NP_729748.3	EGF_CA	156..190	CDD:238011
		EGF_CA	192..233	CDD:238011
		EGF_CA	290..328	CDD:214542
		EGF_CA	330..374	CDD:214542
		EGF	427..455	CDD:278437
		EGF_CA	462..496	CDD:238011
		CUB	503..619	CDD:238001
		CUB	624..738	CDD:238001
		CUB	745..854	CDD:238001
		CUB	857..963	CDD:238001
		CUB	1066..1179	CDD:238001	37/205 (18%)
		CUB	1185..1293	CDD:238001	23/128 (18%)
		CUB	1303..1406	CDD:238001	20/109 (18%)
		CUB	1411..1523	CDD:238001	21/123 (17%)
		CUB	1530..1648	CDD:238001	22/119 (18%)
		CUB	1754..1862	CDD:238001
		CUB	1979..2091	CDD:238001
		CUB	2096..2193	CDD:294042
		CUB	2210..2321	CDD:238001
		CUB	2327..2441	CDD:238001
		CUB	2688..2782	CDD:294042
		CUB	2810..2911	CDD:238001
		CUB	3029..3143	CDD:238001
		CUB	3169..3249	CDD:294042
		CUB	3499..3607	CDD:238001
mep1bb	XP_009294699.1	ZnMc	39..267	CDD:294052	47/223 (21%)
		Astacin	81..269	CDD:279708	38/194 (20%)
		MAM	277..441	CDD:279023	35/188 (19%)
		MAM	277..440	CDD:99706	35/187 (19%)
		MATH	440..608	CDD:295307	39/223 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3714
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900