DRSC/TRiP Functional Genomics Resources

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Protein Alignment Cubn2 and Cubn

DIOPT Version :10

Sequence 1:NP_729748.3 Gene:Cubn2 / 39334 FlyBaseID:FBgn0259140 Length:3613 Species:Drosophila melanogaster
Sequence 2:NP_727348.2 Gene:Cubn / 326235 FlyBaseID:FBgn0052702 Length:3750 Species:Drosophila melanogaster


Alignment Length:3977 Identity:1150/3977 - (28%)
Similarity:1766/3977 - (44%) Gaps:700/3977 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly    41 NLLLEPAWDRNVSLRLMGESATVTIN-DVDMMTVLRRRQRIIADRQAARREPLKVDAVRDMFHDV 104
            ||:.|...:||:|.||.|.| .:||| ::|:|.:|      :|...:.:|...|.|...|. .::
  Fly    41 NLIFESGANRNISFRLSGNS-RLTINEELDVMELL------LATSGSKKRSGGKDDDFVDA-REL 97

  Fly   105 ELKMTRIQRRIFSA----------RNSTKRSGLNQRILRRQLQRVERVKGILQTLAGNLARNECL 159
            ..::....||.|.|          :|.|:.|   ..:|||...|:..::..:..:..:|..|.|.
  Fly    98 ADQLADFNRRAFGANGLSAMLRVQQNRTRGS---MALLRRFQTRLRALENRVDRMKTDLEANSCA 159

  Fly   160 SNPCKNGGTCHDAYKGFQCECPAGWQGDSCEDDVNECFTLAGTDLDGCLNNGQCINTPGSYRCVC 224
            |.||:|||||::.|.||:|:|.:.::|..||.|||||....|||| ||.|.|||.|..|:|.|:|
  Fly   160 SGPCENGGTCYNTYTGFRCQCRSAFEGTKCEMDVNECALYEGTDL-GCQNGGQCQNHFGTYSCLC 223

  Fly   225 RNGFTGTHCRLRHNTCLFGGSRELCGEHGTCIQAANSAGYVCICDQGWTWADANVTSASPSACVR 289
            :.|:.|.||..|...|....:.|||| ||:|:.:|:.|||.|||:.||.      |:.....|..
  Fly   224 QPGWHGMHCTQRKADCSQSSAWELCG-HGSCVPSADDAGYRCICEPGWK------TNGLTPICGE 281

  Fly   290 DVDECEPRV--NPCHDECINLPGSFRCGACPTGYTGDGRFCRDIDECASEDNGGCSLQPRVTCTN 352
            |||||....  .||...||||||||.|..||.|.||:|..|||:|||.: :||||||.|:|.|.|
  Fly   282 DVDECSDSAAHKPCSTSCINLPGSFTCAPCPAGLTGNGVSCRDLDECQT-NNGGCSLSPKVDCIN 345

  Fly   353 TEGSHRCGRCPAGWTGDGRTCTASDSN----------SC---NNEGICHPLAKCEYVSDMVVCTC 404
            |.||:.||.||.|||||||.|..|..:          :|   ||.  |:|.|.|..:|....|.|
  Fly   346 TYGSYHCGECPVGWTGDGRKCERSPQDIDIPAGQTPRTCPAGNNP--CYPTASCFLISGTTSCRC 408

  Fly   405 PLGSFGHGYGADGCSADSSRLPCDQHPCQNNGTCVQNGRGT-TCICQPGYSGVVCNSSDA-CHPS 467
            |:|..|.|||.:|| .:.:...|.::||.|.|.|:..|... ||:|..|:...:|....: |...
  Fly   409 PMGMVGTGYGPNGC-VNGTTTNCKENPCLNGGICLFAGPSNYTCLCPIGFRPPICEPQPSPCDQH 472

  Fly   468 PCLNGGTCRLLPDAK---YQCVCPRGYTGTTCSHQRFFCGVTIRGPSGQLHYPPNTADGDYQADE 529
            ||.|||.||  |...   :.|.|..||.|..|..:...|...:...||:|.|||...  .|:.:.
  Fly   473 PCKNGGRCR--PTTSGDLFVCQCLPGYRGRLCETRFSSCNGMLSAQSGRLRYPPEGT--GYEHNA 533

  Fly   530 RCPFIIRTNRNMVLNLTFTQFQLEDSADCTADFLQLHDGNSLSSRLIGRFCGSRLPMTNGSVITT 594
            :|.::||||.::|:|:||..|.:|||.:|..|:||::||.|.::::|||:||:.|| ..|:::::
  Fly   534 QCAWVIRTNESLVVNVTFNSFDVEDSTECRFDWLQINDGRSAAAQIIGRYCGNHLP-HGGNIVSS 597

  Fly   595 QEQVFFWFRSDNQTQGKGFHVIWNSLPFSCGETINLTSTQTGVLRSPGYPGQARPELDCRWQLTA 659
            ..|::.||||||.|..:||.:.|||:...||..:|..:  .|.|.|||.||......||||||.|
  Fly   598 GNQLYLWFRSDNSTAKEGFDLTWNSMEPQCGGRLNFET--HGTLASPGSPGNYPKNRDCRWQLVA 660

  Fly   660 PFGYRLLLRFYDISLGSSEASAGNCSQDSLIVYD--SDRQLLRACQSIQPPPVYSSSNSLRLDFH 722
            |...|:.|.|:.:.|   |..| ||:.|.:::.|  |.|:|.:.|.:..|.|:...::...:.||
  Fly   661 PTTKRIKLTFFSLQL---EQHA-NCNFDYVLIKDSISGRELAKYCTTGAPAPLLLPTHLAEIHFH 721

  Fly   723 TDAIRSDSSFQMHYEVVPGHPGCGGVYTESRGRI--SGYMNFE----VCLYLIEQPRGTQVKLVI 781
            :||..||:.||:||.|....||||||||...|.|  |...|.|    .|.|.|....|.||.:..
  Fly   722 SDAEGSDTGFQLHYSVEERVPGCGGVYTAKEGTISESSTANTEPGGVSCEYEIHLAVGEQVVIQF 786

  Fly   782 DRVSLVQSLSCHYLKIEIFDGRSTDAPLLR-RICGSHEESELEP--IISIGNVILVRYEYALSGV 843
            .|:.| ..|.|    :|:.|.......:|: :|||| :.|.|.|  ..|..|.:.::: ||.:| 
  Fly   787 ARLEL-DPLDC----LEVLDITDEGGSILQEKICGS-DASRLNPPTFTSEFNRLKIKF-YARAG- 843

  Fly   844 RLSKSFDLTYTRVCTGNFNTNSGIISTPNYPGPYFDDMTCTYNLTGPLDTAVRMRITDLSLGTAN 908
                ||.|.|...|....|...|.|::|.||.....|..|||.::...:|.:.::..|..|....
  Fly   844 ----SFQLNYRMACDYKLNNEQGTITSPGYPNLTRSDRICTYTISTATNTVISLKRIDFQLTNGE 904

  Fly   909 NEND-------------------------------------TSYLDVYLSADQKRHIVKSTDNLI 936
            :::|                                     |:||.::||.|        .|:: 
  Fly   905 SDDDDNDECLTTNLRINDGLNRKILGPYCGKNQPEENFVSETNYLQLHLSTD--------VDSM- 960

  Fly   937 LLSHSNRASLVFHGSGGGRGMRLEYNFVP---NQCGGFLNEPGRRYVTAVRG------TFCQWFI 992
                             |||.:.||..:.   ::|||.....|......|..      ..|.|.|
  Fly   961 -----------------GRGFKFEYRALATGNDKCGGVHTRSGDHIRLPVHDDSYAGEATCYWVI 1008

  Fly   993 DFPGRKKISIH----TLGPTPS-----ISIYDNSTSPGKLVNSYSGS-----VGDVFDGDLLTIN 1043
            ..|..|.|.:|    :|.....     :.|||   |.|..||.....     .|:....|||:  
  Fly  1009 MAPANKAIRLHWNSFSLENAVDCIYDYLEIYD---SLGAQVNDERSKPLAKYCGNSVPEDLLS-- 1068

  Fly  1044 LHTNWPRLEI----------YSIQFDIVQQDSCGGTFTARFGYIKSPNWPKNYGESQMCEWILRA 1098
             |:....|:.          :.:.:....:..|||...|..|.:.||.:|.||.....|:|.|..
  Fly  1069 -HSRQLVLKFVSDYSESDGGFDLTYTFEDRAKCGGHIHASSGELTSPEYPANYSAGLDCDWHLTG 1132

  Fly  1099 PFGHRIELVVHNFTLEEEYSSTGCWTDWLEIRNGDSESSPLIGRYCGNEIPSRIPSFGNVLHLKF 1163
            ...|.:|:.|.||.||:   |..|..|:||:|||....||||||:||.:||:|||.|.:.:.|..
  Fly  1133 TIDHLLEIQVENFELEQ---SPNCSADYLEVRNGGGTDSPLIGRFCGRDIPARIPGFSHEMRLIL 1194

  Fly  1164 KSDDSMEEKGFLLSWQQMGAGCGGKLSSSMGTIHSPHLLAGNRGILACDWQIIVAEGSRVSLQLR 1228
            .:|.::..:||.|.|:....||||.|.|:||.|.||........:..|:|:|.:..||.:||.:.
  Fly  1195 HTDSAINGRGFRLRWRIFAFGCGGSLRSNMGAISSPRYPNSYPNMAHCEWRISLHPGSGISLLIE 1259

  Fly  1229 SNDNRICSG----QLTLYDG---PTTASNPIVIRC-NGTIAKPL-QSTGNRVLVRYDVGHDAPDG 1284
            ..:....|.    .:.:|.|   |.  .:|..:.| :..:..|| |...|:..:.:|  .||.:.
  Fly  1260 DLELEGLSNCYYDSVKIYTGIKLPN--QSPCKVLCKDDDLHNPLIQLENNKGTIVFD--SDASNT 1320

  Fly  1285 -TDFMLNYQTNCRVRLEGLQGAIETPNFPENY----PPGQDCEWDIRAGGRKNHLQLIFSHLSVE 1344
             ..|.::|:.||...|....|.||:.|:.|.:    |  .:|.|.||| .:.|.:.:..|||:  
  Fly  1321 FRGFRISYKANCIRNLTATTGTIESLNYMEPFWETIP--INCSWTIRA-PKGNRVLVEVSHLA-- 1380

  Fly  1345 KFSSICLNDYVSLVDMLDDQTLSEQHLCTN---------DG--LEPITT-----VGNRLLLRFKS 1393
                                 ..|||:.|.         ||  ::.|.|     :...:|....:
  Fly  1381 ---------------------RHEQHVPTATMPGGLYIVDGRNVQEIVTPQAMNISGEVLTVVHN 1424

  Fly  1394 DSSVELQGFRAEYKRIGCGEHLRESGGRFESPNAP--FSVDMDCVWIITASEGNQIRLLLHEVYF 1456
            .|:|   .|:.:|:..||.|.||.:.|.|:|||.|  :..:::|.|:||..:.:.|.|.::.:..
  Fly  1425 ASNV---NFQLDYRIDGCMEELRGTFGFFQSPNYPKMYPNNLECYWLITVEQDSAIELTINNIDL 1486

  Fly  1457 EAPQIECRDAESSLSVSAPSGYNSSVVLFRSCHEETQTQTFTSPGNELVIRFVSSSAPSRKYFKA 1521
            |......:||   |:||  :..||..|..|.|...|:. ..||.|:.|.:||:|.::.:...|:|
  Fly  1487 EDSPNCTKDA---LTVS--NHKNSVEVHERHCGSTTKL-VITSSGHRLHVRFISDNSHNGLGFEA 1545

  Fly  1522 SFVQVPASCGGYISASSGVLTTPGFHNHQDSKNVANYTSNIECVWTVEVTNGYGIRPHFEQFNLT 1586
            ::..|.|:|||.::|.:||:.:|.:        ..||.::..|.|.|||:..:.|.......||.
  Fly  1546 TYRTVKATCGGKLTARNGVIESPNY--------PLNYPAHSRCEWQVEVSQHHQIVFEMADLNLE 1602

  Fly  1587 DSGNCSVSFVE---LTKLEPDNKEIFLEKTCGEDSPMIRIV--HGRKLRVRFKSQAGTWGR-FIM 1645
            ...:|:..::|   ||:.:.:.:.:|  |.||:::...:::  ......|||.|......: |.:
  Fly  1603 SGYDCNWDYLEAYDLTEDDTEGERLF--KVCGDETEDDKLLSSSSNMAVVRFISDDSVSKKGFRL 1665

  Fly  1646 YFERQCGGRLSTGE---GYL----QSRLDEECSW----------LVTSPEGSKLSLIINQLECP- 1692
            :|...||..:...|   .|:    |:..:|.|.|          ::.:|...||....|| :.| 
  Fly  1666 HFHESCGQTIIVDETMFDYIQMSRQAARNESCLWVFQAVEPNKRIIFTPTHVKLREDANQ-QYPT 1729

  Fly  1693 --KCNAVSQNCSEGLQLLNDDDQVLLYQMCRDHPANLIVPANNVRILTHGIRL------QAQFST 1749
              .|..|.....||    .:.......:.||.||..||   :|.:.||..:.|      |..:.|
  Fly  1730 EGDCLNVGVKIYEG----TEPQGTPRLKFCRSHPPALI---SNGQALTVSVPLQLVEEFQGHYMT 1787

  Fly  1750 FENSCGGNITSASGSLSSPNYPDSYPANIECVWSIRTRPGNALEITFEAMDIVRSEHCNDDFLEI 1814
            .:.|||....:.||..:||.||.|||.||||:|.:....||:|.:|.|:||:.:||.||.|:||:
  Fly  1788 MDTSCGSIYNALSGKFTSPYYPASYPPNIECLWLLEASMGNSLSLTLESMDLEKSESCNRDYLEV 1852

  Fly  1815 R-SSVQGPLLALYCDKNLPETPLVVHSE--LWIKFRSRPGNTAGGFRFRWTYVHNNEINSGINGT 1876
            | .|..|.|:.:||..   |.|.|:||.  :|:||:|...|...||...:.|.|:||:| |..||
  Fly  1853 REESESGQLIGVYCGN---EVPGVIHSRGAIWMKFKSDDDNVGEGFMASYNYEHHNELN-GTEGT 1913

  Fly  1877 IEPP--PPLFVSNEDQPFTWRLFTDFKKVFVLQFEEYISGLIL-------------FDGYDDNAL 1926
            ||.|  |..|  .:..|::||:..|         :||:..:.|             :|||.|...
  Fly  1914 IESPHFPSKF--QDPVPYSWRITVD---------KEYVVAISLLYLRDLDQPHLNFYDGYSDIGA 1967

  Fly  1927 AVNIPVSPWRFTSSSNVVYLKTVNDALTHFRLKWGVLDSNLVASNLSL--TTGGCTKELTLSHHG 1989
            .:.:........||:||||. |.|..  .|:|.|..|....:.||.:.  .|..|..:|......
  Fly  1968 RIEVTDPDETIISSTNVVYF-TSNRG--PFKLNWNRLSKEALRSNRTAEERTRQCGNQLITIDRS 2029

  Fly  1990 DIELSSPGYPHGYAPNLNCEWTIRSQFPSHHIYAHSIIVDLEDYPA-CSADYLSIQSSRDLIKWK 2053
            .|...|||||:||..:|||.||:....|:.|.......:|||.:.. |.|||:.|.|..||..|.
  Fly  2030 VIGFHSPGYPNGYEQDLNCFWTLVPSNPAMHAVLTLSQIDLEIFSEDCIADYVKIFSGSDLQNWS 2094

  Fly  2054 NELHACK---ASQIAPVHGTPYLRLQFRSDVSINGTGFRAKLRTSCGS---------NMTGIVGT 2106
            .....|.   .|.....||.||||::|.:|.|:|.|||...:||:|||         |:|.|:..
  Fly  2095 ELRTLCSLPTESSDRVFHGRPYLRVEFVTDPSVNKTGFNGIVRTACGSEITASKGLVNITEILKV 2159

  Fly  2107 IPQENLFDECAWHIDVRPGRKI-----DIAINYNNMPPIAVCEAYGLIYDGVDEHASLLEHTRFG 2166
            :|:.|  .:|.|.|.||.||:|     |..:..|.....:.|..|.|:.:|.||.:..|...::.
  Fly  2160 LPRPN--HDCVWTIKVRQGRRIKIDFPDFQLQNNMASGSSDCRNYLLLRNGNDEDSPFLGRGKYC 2222

  Fly  2167 NQMGIRRTQFRTSGSHAYIKYHIGRSRINGLCLWNLTYREFNEC----NGEIQLNQQAPNYTIMS 2227
            ..  :......||.:.||||:|.....     .:.:::| |.|.    :|.|:|:.......|.|
  Fly  2223 ED--VVHEVLNTSSNKAYIKFHFASPP-----RFLVSFR-FEELRYTDSGRIRLSASGDEQFISS 2279

  Fly  2228 PGYPYLPHPHAECTWLVMAPPGETIAVDFDEQFEL-----SARHCDKENVEFFDGATKLARLLLR 2287
            |.||:|||||:||.|:|.|||...|.:.|...|::     ....|.:|.|...||:|:|...:.|
  Fly  2280 PYYPHLPHPHSECIWIVEAPPEHRIMLHFQGAFDMLDATGEPEECQREFVLINDGSTELRPEIGR 2344

  Fly  2288 TC--RKPQNTVRTTGNLLLVHYQSQLNEPTGGFRLNLSLSTCGGQFSASAGFISSENYP----HL 2346
            .|  ||| :|:.:|||.:.:.|.:.::||..||..:||::.|||.|.:..|.|:|.:..    |.
  Fly  2345 YCGNRKP-DTIYSTGNQMRIRYFTDVSEPHMGFNASLSVARCGGSFHSPEGVIASPSRDLLLIHE 2408

  Fly  2347 GGYPKPSVCEYSILLPKNAFIRLNITDLHLPYDANGTSSDRLEI---------VDYEDRTQKLMV 2402
            .| .:...|.|:|.|.|.:.|.|....|.:|...||:.|.|..:         :|.|::....::
  Fly  2409 EG-KQLQECVYTIELEKGSTIDLTSEYLQIPTLRNGSCSQRNHLMLEEMDAFGLDGEEKIVDTLM 2472

  Fly  2403 LDGRTKTSILFTLNTNAATIRF---VAVQNVNNYRGFKIRYERYVGTCSRDINGASGDIVIPPMP 2464
            |.|.....::...|......||   :..:|    :||:::|......|...|..:.|.:..|..|
  Fly  2473 LCGMEAKHLISETNKIVFRYRFLDGIPAEN----QGFRLKYTSLGSRCGETIYASVGVLQTPGYP 2533

  Fly  2465 QSV-WLRFCRLRISVPKGQRVRLNLLNLSNIRVVKRNDTNRSFMQIGRLESMAHFSFYNDANSLS 2528
            ..| ....|:.::.||||:||||.:|:.:       ..||....  |||......:..||....|
  Fly  2534 LGVPHPMHCKWQVQVPKGRRVRLEILDFN-------TGTNMDLR--GRLGFRGRLTVANDFKMQS 2589

  Fly  2529 KIAEFRID------GGYNGSGIIESTDNYMLVVVMTNQLDLSATPLRARYSSSEPTVCPP-NIGD 2586
            .:..:.:|      ...|..||    |.::|.:|..:.:.|       |:|:...:.||. .:..
  Fly  2590 ILGRYNVDPPAEVLSSDNTMGI----DAFLLPIVQNHGIKL-------RFSAYGSSSCPGFTVMM 2643

  Fly  2587 QATGSISIQSLLQVPGYHCTIKFVGTDSATLTFKVEEY------LFQT----------------- 2628
            .....|..|........||:.|.|...::||..:|:||      ::.|                 
  Fly  2644 NEVADIQFQRFNISRPLHCSYKVVPPSNSTLLIRVKEYNTTSVMMWNTHMCALLSPLKFNRLEQE 2708

  Fly  2629 ---------------AGGPAVVFRDDITNIPVK-AMYANVTNSFVSVVTSAGSVTLLNSKNVKLR 2677
                           .|.|....|   ...|:: .:.|:..|:..::|.|               
  Fly  2709 EELMERILCDYQSPAPGKPLPSIR---LPFPIQLVVSASARNAMTNLVLS--------------- 2755

  Fly  2678 RFRATYRRHNCGG--RLQAAEGVTIESPDLLTTLNDAYGEVECLWTL---SNSNG---------- 2727
                 |...:|||  .|:..:.:|:..|..:.:   |.|.::|.|.:   ::::|          
  Fly  2756 -----YSTQSCGGVIILEPGDNMTVHQPSGMVS---AAGAIDCAWAIGPYTDASGEDEVLVPQDI 2812

  Fly  2728 --YVLEGNVTL----------TDRCDREYIVIFSGQSE----VGRICRGMAMNSTLLERPFSTIL 2776
              .|...||.|          ...|...|:.:::|..:    :|..|......:.::||.. .:.
  Fly  2813 QLEVSVYNVNLPAPSPSAQSPEAPCLHHYLKVYNGPDQNSPSLGLFCNQATAVNMVVERGL-FLE 2876

  Fly  2777 YHSESRLAQQSKFILQAWKSVSSGNAI----RIDHRPSPPVTISSKNYLESKQRIWEFVTNDGLS 2837
            |||:|..|..:..:...:.|...|..:    .||.         ::.|..:.:.|||.....|..
  Fly  2877 YHSDSFSANATFNVSIKYGSGCGGKLVYPYRAIDF---------AEQYKNNVECIWEVEATMGYH 2932

  Fly  2838 LRLHFLERIFIVSSPNCSTDRLTVERYDQTTEEYIEVTSLCGRQAANDILVPSARMRVIFQTNSN 2902
            :.|.|..|.:|..||.|:.|.|.|::.::||..:.::..:|||.|...|...|..:|:||:::.:
  Fly  2933 IGLTFQGRFYIEDSPGCTKDYLLVQQRNETTGNWTDLQRICGRVAPEMINTTSPYLRLIFRSDGD 2997

  Fly  2903 ITGDGFSFQVIPSCDSVLLAGAEIQTLASPSWAAFRGRQFNCSYTFY------------------ 2949
            :..|||..:...:|..:|.|.:..|.||||.:.....:...|::|..                  
  Fly  2998 VVADGFLAKFERNCGGLLYADSTEQELASPGFPNGYEKYLQCNWTIVPRSPSMGGVLVSFVNFDL 3062

  Fly  2950 --------AHDNHQVVVSVRTRGR-PWASYACSRSYFEAYRRGDGNGVGEESIGRLCPEFEVKGN 3005
                    .:||  :.|:.:.:|: |..:..|...:...||       |:|.:..|     ::.:
  Fly  3063 EQGPISVCLYDN--LTVTTKDKGKDPQQTTLCGVKHNHEYR-------GKEYVNLL-----LRTD 3113

  Fly  3006 GRVRLRYVSPLSRWFEMQYQLIQCGGNYS-TSFTLRPPQNEDSSVYAHNTL-----CEWRITAPP 3064
            |       |...|.|.:.|....|||..| ||....|.|:.|      |||     |.|.:|||.
  Fly  3114 G-------SYSGRGFTLLYTSRLCGGIISRTSMVESPVQHTD------NTLPPGSDCYWNLTAPA 3165

  Fly  3065 QHAVVIEFKYFDMESSRNCGFDSLTIYRGHVVSEEQRTGLLCGNVTNPETII-VNSNEALIVLTT 3128
            .:...|:|.:.|.|::.||.:|.:.::.|.:..|..|.|..||.:.....:| :.....:|...:
  Fly  3166 GYKFNIKFLFIDFEANSNCAYDGVEVFSGPIPDERYRWGRFCGRINEDLPLISIPQERGIIHSFS 3230

  Fly  3129 DSSNSYRGFLASVRFTPNCNEHVALDLEVPRMSVMRQYVVN-------ISESLLCIFQASAPPDY 3186
            |..:..|||.|.||..|||:|.::|       :...:||.:       ....|.|.......||.
  Fly  3231 DDRDPSRGFRALVRVMPNCDEKISL-------NGSSRYVYSKFNNAGGYQNDLDCQIVFRVNPDQ 3288

  Fly  3187 RISLEVRKLQLADDVVCRTCSYLEIHDSKDVEGQNLGRYYGGTNGNEPSNRTKVFSSFSDMSFKL 3251
            :||:|.....:.|...||: .|:|:.|........:||:.|  ....|:.||...:.:  |.|  
  Fly  3289 QISVEFSNFHVQDTDGCRS-DYVELRDGGGTFADIIGRFCG--QNQPPTLRTTRHTLY--MRF-- 3346

  Fly  3252 IATTGQAQKNISFELILQMVRTVCGQGEYDLRLNET--ITLGMQYDNSTRFYEGSIQCLWIIKNK 3314
              .|.....:..|::.:..:..:||..|..|..:.|  :|:..........|...:.|.|.||..
  Fly  3347 --VTDNKVTDTGFQVTINAIPRLCGSSEITLSADGTKEVTINSPARTPGGNYPNGVSCFWKIKGD 3409

  Fly  3315 GDVELEFRKLRLKEISQGTGKCT-DYLKL------------------------SKPYF----SRS 3350
            ..:.::|....|...:| .|.|. ||||:                        ||..|    ...
  Fly  3410 SLLRVQFVNFDLHGPNQ-NGSCVDDYLKIYNSEDAPLLEQGLGTDLVFNGQTSSKNGFGFATEHV 3473

  Fly  3351 YCGQHDKSFKIVEEV---NESNLQLAFHSDGLEESQGFEVIIRRKSTCNRNYTELSQVIDTSNLT 3412
            |||      .:..::   ..|.:.|.|.|.|||:..||::.:...|...|:|..|...:..|...
  Fly  3474 YCG------NVKPDIYYGRSSEVYLKFRSKGLEQHGGFQLQVALNSNRERHYDGLQGRVHLSQSA 3532

  Fly  3413 NCTDYIRVPRGYSITLYVMTVLFDSFDNNYFRVIDVQSNKTIF--TNSDIQWET------KAMIT 3469
            :|...||.|..|:::||...::|.::|..       ..|..:|  ||..:|...      |::.:
  Fly  3533 DCNIIIRAPPNYTLSLYYTELIFGTYDCE-------MENLEVFDRTNRSLQRVCSFVDMGKSLFS 3590

  Fly  3470 STNELRLESR---QVSSLKFFYFSTSNQFPGGCGGDLAVGGSVGSYLENPSYEG--RNSSLCTWK 3529
            :.|||||:.:   .::||...|.::..:...||||...   :......||.|..  ||:|.|.|.
  Fly  3591 NANELRLQMKTGSYLTSLDLTYLASPVEKGPGCGGQFY---NTEGIFSNPFYPNNVRNNSECQWI 3652

  Fly  3530 ISVPAGGSLRFSFAEFNMGSESNCDLDNVRFYD-SVVDDQRLVKAICGSRIPDMFTIAKNNVIIV 3593
            :.||:...:..:|..||:||::.|..|.::..: ....::|.::..||...|..:...::.|::.
  Fly  3653 VRVPSNNVVFLTFEVFNLGSKTTCHTDYLQILEQDATGEEREMRRFCGEDNPKYYKSRRSQVLVR 3717

  Fly  3594 AKKSQNFDGLGF 3605
            ..|:.|:||:|:
  Fly  3718 FHKTVNYDGIGW 3729

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Cubn2NP_729748.3 cubilin_NTD 38..141 CDD:412063 32/110 (29%)
EGF_CA 156..190 CDD:238011 16/33 (48%)
EGF_CA 192..233 CDD:238011 22/40 (55%)
EGF_CA 290..328 CDD:214542 22/39 (56%)
EGF_CA 330..374 CDD:214542 28/43 (65%)
EGF 427..455 CDD:394967 11/28 (39%)
EGF_CA 462..496 CDD:238011 14/37 (38%)
CUB 503..619 CDD:238001 47/115 (41%)
CUB 624..738 CDD:238001 44/115 (38%)
CUB 745..854 CDD:238001 39/117 (33%)
CUB 857..963 CDD:238001 27/142 (19%)
CUB 1066..1179 CDD:238001 47/112 (42%)
CUB 1185..1293 CDD:238001 32/117 (27%)
CUB 1303..1406 CDD:238001 27/122 (22%)
CUB 1411..1523 CDD:238001 37/113 (33%)
CUB 1530..1648 CDD:238001 30/123 (24%)
CUB 1754..1862 CDD:238001 48/110 (44%)
CUB 1979..2091 CDD:238001 44/115 (38%)
CUB 2210..2321 CDD:238001 44/121 (36%)
CUB 2327..2441 CDD:238001 32/129 (25%)
CUB 2688..2782 CDD:412131 25/124 (20%)
CUB 2810..2911 CDD:238001 29/100 (29%)
CUB 3029..3143 CDD:238001 38/120 (32%)
CUB 3169..3249 CDD:412131 20/86 (23%)
CUB 3499..3607 CDD:238001 30/110 (27%)
CubnNP_727348.2 cubilin_NTD 21..149 CDD:412063 32/118 (27%)
EGF_CA 156..190 CDD:238011 16/33 (48%)
EGF_CA 192..233 CDD:238011 23/41 (56%)
EGF_CA 282..322 CDD:214542 22/39 (56%)
EGF_CA 324..367 CDD:214542 28/43 (65%)
EGF 430..457 CDD:394967 10/26 (38%)
EGF_CA 469..503 CDD:238011 14/35 (40%)
CUB 509..622 CDD:238001 47/115 (41%)
CUB 627..737 CDD:238001 44/115 (38%)
CUB 744..849 CDD:412131 39/116 (34%)
CUB 853..970 CDD:238001 27/142 (19%)
CUB 978..1094 CDD:238001 26/121 (21%)
CUB 1100..1211 CDD:238001 48/113 (42%)
CUB 1216..1330 CDD:238001 32/117 (27%)
CUB 1446..1549 CDD:238001 33/108 (31%)
CUB 1554..1667 CDD:238001 30/122 (25%)
CUB 1792..1899 CDD:238001 48/109 (44%)
CUB 1910..1998 CDD:412131 28/101 (28%)
CUB 2019..2133 CDD:238001 43/113 (38%)
CUB 2140..2242 CDD:238001 31/105 (30%)
CUB 2263..2379 CDD:238001 44/116 (38%)
CUB 2385..2511 CDD:238001 33/130 (25%)
CUB 2516..2630 CDD:238001 33/133 (25%)
CUB <2833..2892 CDD:412131 12/59 (20%)
CUB 2898..3008 CDD:238001 32/118 (27%)
CUB 3011..3127 CDD:238001 26/136 (19%)
CUB 3130..3241 CDD:238001 36/116 (31%)
CUB 3254..3363 CDD:238001 26/124 (21%)
CUB 3379..3508 CDD:238001 31/135 (23%)
CUB 3531..3601 CDD:412131 20/76 (26%)
CUB 3623..3733 CDD:238001 30/110 (27%)

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