DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Cubn2 and N

DIOPT Version :10

Sequence 1:NP_729748.3 Gene:Cubn2 / 39334 FlyBaseID:FBgn0259140 Length:3613 Species:Drosophila melanogaster
Sequence 2:NP_476859.2 Gene:N / 31293 FlyBaseID:FBgn0004647 Length:2703 Species:Drosophila melanogaster


Alignment Length:1901 Identity:402/1901 - (21%)
Similarity:584/1901 - (30%) Gaps:707/1901 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly   155 RNECLSNPCKNGGTCHDAYKG---FQCECPAGWQGDSCEDDVNECFTLAGTDLDGCLNNGQCINT 216
            :|.|.|:||:||.|| .|..|   |.|.||.|:.||:|..|:.||      ..:.|...|.|:||
  Fly   178 KNLCASSPCRNGATC-TALAGSSSFTCSCPPGFTGDTCSYDIEEC------QSNPCKYGGTCVNT 235

  Fly   217 PGSYRCVCRNGFTGTHCRLRHNTCLFGGSRELCGEHGTCIQAANSAGYVCICDQGWTWADANVTS 281
            .|||:|:|..|:||..|..::..|    |...|...|.|  .:|...|.|.|.:|:...:     
  Fly   236 HGSYQCMCPTGYTGKDCDTKYKPC----SPSPCQNGGIC--RSNGLSYECKCPKGFEGKN----- 289

  Fly   282 ASPSACVRDVDECEPRVNPCHDECINLPGSFRCGACPTGYTGDGRFCR-DIDECASEDNGGCSLQ 345
                 |.::.|:|...:......||:....:.| .||..:|  ||||: |:||||..|:..|  |
  Fly   290 -----CEQNYDDCLGHLCQNGGTCIDGISDYTC-RCPPNFT--GRFCQDDVDECAQRDHPVC--Q 344

  Fly   346 PRVTCTNTEGSHRCGRCPAGWTG----------------DGRTC--------------------- 373
            ...|||||.||:.| .|..||.|                .|.||                     
  Fly   345 NGATCTNTHGSYSC-ICVNGWAGLDCSNNTDDCKQAACFYGATCIDGVGSFYCQCTKGKTGLLCH 408

  Fly   374 --TASDSNSCNNEGIC--HPL---------------------------AKCEYVSDMVVCTCPLG 407
              .|..||.|:.:.||  .|:                           :.||:..   :|....|
  Fly   409 LDDACTSNPCHADAICDTSPINGSYACSCATGYKGVDCSEDIDECDQGSPCEHNG---ICVNTPG 470

  Fly   408 SF----GHGYGADGCSADSSRLPCDQHPCQNNGTCVQNGRGTTCICQPGYSGVVCN-SSDACHPS 467
            |:    ..|:....|..:.:.  |:.|||||.|:|:.:.....|:|.||::|..|. ..|.|..:
  Fly   471 SYRCNCSQGFTGPRCETNINE--CESHPCQNEGSCLDDPGTFRCVCMPGFTGTQCEIDIDECQSN 533

  Fly   468 PCLNGGTCRLLPDAKYQCVCPRGYTGTTCS-----------HQRFFCGVTIRGPSGQLHYPP--- 518
            ||||.|||....:. ::|.|..|:||..|.           ..|..|..:|.|.|.:.  ||   
  Fly   534 PCLNDGTCHDKING-FKCSCALGFTGARCQINIDDCQSQPCRNRGICHDSIAGYSCEC--PPGYT 595

  Fly   519 ------NTADGDYQADERCPFIIRTNRNMVLNLTFTQFQLEDSADCTAD-----FL---QLHDGN 569
                  |..|.|.....|...|...|                |..|..|     ::   |:::..
  Fly   596 GTSCEININDCDSNPCHRGKCIDDVN----------------SFKCLCDPGYTGYICQKQINECE 644

  Fly   570 SLSSRLIGRFCGSRLPMTNGSVITTQEQVFFWFRSDNQTQGKGFHVIWN---SLPFSCGET---- 627
            |...:..|. |..|:    ||         ::.:....|.||...|..|   |.|.:.|.|    
  Fly   645 SNPCQFDGH-CQDRV----GS---------YYCQCQAGTSGKNCEVNVNECHSNPCNNGATCIDG 695

  Fly   628 INLTSTQTGVLRSPGYPGQ-ARPELD-CRWQLTAPF-----------GYRLLL--RFYDISLGS- 676
            ||....|.    .||:.|| ....:| |   :::|.           ||:...  .|||....| 
  Fly   696 INSYKCQC----VPGFTGQHCEKNVDEC---ISSPCANNGVCIDQVNGYKCECPRGFYDAHCLSD 753

  Fly   677 -SEASAGNCSQDSLIVYDSDRQLLRACQSIQPPPVYSSSNSLRLDFHTDAIRS----------DS 730
             .|.::..|..:.. ..|...:.:..|     ||.|:..   |.:...|...|          |.
  Fly   754 VDECASNPCVNEGR-CEDGINEFICHC-----PPGYTGK---RCELDIDECSSNPCQHGGTCYDK 809

  Fly   731 SFQMHYEVVPGHPG--CGGVYTESRGRISGYMNFEVCLYLIEQPRGTQVKLVIDRVSLVQSLSCH 793
            ......:.:||:.|  |             ..|.:.|   :..|.|.. ...||:|:   ...| 
  Fly   810 LNAFSCQCMPGYTGQKC-------------ETNIDDC---VTNPCGNG-GTCIDKVN---GYKC- 853

  Fly   794 YLKIEIFDGRSTDAPLLRRICGSHEESELEPIISIGNVILVRYEYALSGVRLSKSFDLTYT-RVC 857
            ..|:          |...|.|    ||:::|..|.......:...:.:.:..|.:..|.|| |.|
  Fly   854 VCKV----------PFTGRDC----ESKMDPCASNRCKNEAKCTPSSNFLDFSCTCKLGYTGRYC 904

  Fly   858 TGNFNTNSGIISTP--------NYPGPYFDDMTCTYNLTGPLDTAVRMRITDLSLGTANNENDTS 914
            ..:.:..|  :|:|        |.||.|  ...||....| .|.|:                   
  Fly   905 DEDIDECS--LSSPCRNGASCLNVPGSY--RCLCTKGYEG-RDCAI------------------- 945

  Fly   915 YLDVYLSADQKRHIVKSTDNLILLSHSNRASLVFHGSG--------GGRGMRLEYNFVPNQCGGF 971
                            :||:.......|..:.: .|.|        |..|...|.:.  |:|   
  Fly   946 ----------------NTDDCASFPCQNGGTCL-DGIGDYSCLCVDGFDGKHCETDI--NEC--- 988

  Fly   972 LNEPGRRYVTAVRGTFCQWFIDFPGRKKISIHTLGPTPSISIYDNSTSPGKLVNSYSGSVGDVFD 1036
            |::|            ||                          |..:..:.||||:.:....|.
  Fly   989 LSQP------------CQ--------------------------NGATCSQYVNSYTCTCPLGFS 1015

  Fly  1037 GDLLTINLHTNWPRLEIYSIQFDIVQQDSC---GGTFTARFGYIKSPNWPKNYGESQMCEWILRA 1098
            |    ||..||          .:...:.||   |.......||                      
  Fly  1016 G----INCQTN----------DEDCTESSCLNGGSCIDGINGY---------------------- 1044

  Fly  1099 PFGHRIELVVHNFTLEEEYSSTGCWTDWLEIRNGDSESSP-LIGRYC---GNEIPSRIPSFGNVL 1159
                       |.:....||...|     :.:....:|:| |.|..|   .||.....||     
  Fly  1045 -----------NCSCLAGYSGANC-----QYKLNKCDSNPCLNGATCHEQNNEYTCHCPS----- 1088

  Fly  1160 HLKFKSDDSMEEKGF-------LLSWQQMGAGCG------GKLSSSMGTIHSPHLLAGNRGILAC 1211
                         ||       .:.|      ||      |...|.|....|....||..|.| |
  Fly  1089 -------------GFTGKQCSEYVDW------CGQSPCENGATCSQMKHQFSCKCSAGWTGKL-C 1133

  Fly  1212 DWQIIVAE--GSRVSLQLRSNDNRIC-SGQLTLYDGPTTASNPIVIRCNGTIAKPLQSTGNRVLV 1273
            |.|.|..:  ..|..|.||    ::| :|....|      .|..|..|:...|      |:....
  Fly  1134 DVQTISCQDAADRKGLSLR----QLCNNGTCKDY------GNSHVCYCSQGYA------GSYCQK 1182

  Fly  1274 RYDVGHDAP---DGT--DFMLNYQTNCRVRLEGLQGAIETPNFPENYPPGQDCEWDI-------- 1325
            ..|.....|   .||  |.:..|:..||   :|.|              ||:||.:|        
  Fly  1183 EIDECQSQPCQNGGTCRDLIGAYECQCR---QGFQ--------------GQNCELNIDDCAPNPC 1230

  Fly  1326 RAGGRKNHLQLIFSHLSVEKFSSICLNDYVSLVDML--DDQTLSEQHLCTNDGLEPITTVGNRLL 1388
            :.||.        .|..|..||..|....:.::..:  ||   .:...|.|:|            
  Fly  1231 QNGGT--------CHDRVMNFSCSCPPGTMGIICEINKDD---CKPGACHNNG------------ 1272

  Fly  1389 LRFKSDSSVELQGFRAEYKRIGCGEHLRESGGRFESPNAPFSVDMDCVWIITASEGNQIRLLLHE 1453
                                 .|.:.:    |.||....|..|...|       ||: |...|..
  Fly  1273 ---------------------SCIDRV----GGFECVCQPGFVGARC-------EGD-INECLSN 1304

  Fly  1454 VYFEAPQIECRDAESSLSVSAPSGYNSSVVLFRSCHEETQTQTFTSPGNELVIRFVSSSAPSRKY 1518
            ....|..::|....::...:...|:     :.|.|..                            
  Fly  1305 PCSNAGTLDCVQLVNNYHCNCRPGH-----MGRHCEH---------------------------- 1336

  Fly  1519 FKASF-VQVPASCGGYIS-ASSG--VLTTPGFHNHQDSKNVANYTSNI----ECVWTVEVTNGYG 1575
             |..| .|.|...||..: ..||  .:...||:......:..:..||.    .||...|   |:|
  Fly  1337 -KVDFCAQSPCQNGGNCNIRQSGHHCICNNGFYGKNCELSGQDCDSNPCRVGNCVVADE---GFG 1397

  Fly  1576 IRPHFEQFNLTDSGNCSVSFVELTKLEPDNKEIFLEKTCGEDSPMIRIV-HGRKLRVRFKSQAGT 1639
            .|....:..|.:  :|.:..::.....|..:....|...|:...:.... .|::..:...:..| 
  Fly  1398 YRCECPRGTLGE--HCEIDTLDECSPNPCAQGAACEDLLGDYECLCPSKWKGKRCDIYDANYPG- 1459

  Fly  1640 WG--------RFIMYFERQ---CGGRLST---GEGYLQSRLDEECSWLVTSPEGSKLSLIINQLE 1690
            |.        |:....|:|   |..|..|   |.|.    .|.:|:....:.:|:..||.||   
  Fly  1460 WNGGSGSGNDRYAADLEQQRAMCDKRGCTEKQGNGI----CDSDCNTYACNFDGNDCSLGIN--- 1517

  Fly  1691 CPKCNAVSQNC----SEGLQLLNDDDQVLLYQMCRDHPANLIVPANNVRILTHG----IRLQAQF 1747
             |..|..:..|    ..|              .|.:.       .||......|    .:|::..
  Fly  1518 -PWANCTANECWNKFKNG--------------KCNEE-------CNNAACHYDGHDCERKLKSCD 1560

  Fly  1748 STFENSCGGNITSASGSLSSPNYPDSY----PANIECVWSIRTRPGNALEITFEAMDIVRSEHCN 1808
            |.|:..|            ..:|.|.:    ..|.||.|                          
  Fly  1561 SLFDAYC------------QKHYGDGFCDYGCNNAECSW-------------------------- 1587

  Fly  1809 DDFLEIRSSVQGPLLA 1824
             |.|:..:..|.|:||
  Fly  1588 -DGLDCENKTQSPVLA 1602

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Cubn2NP_729748.3 cubilin_NTD 38..141 CDD:412063
EGF_CA 156..190 CDD:238011 18/36 (50%)
EGF_CA 192..233 CDD:238011 16/40 (40%)
EGF_CA 290..328 CDD:214542 10/37 (27%)
EGF_CA 330..374 CDD:214542 23/82 (28%)
EGF 427..455 CDD:394967 12/27 (44%)
EGF_CA 462..496 CDD:238011 14/33 (42%)
CUB 503..619 CDD:238001 27/135 (20%)
CUB 624..738 CDD:238001 29/144 (20%)
CUB 745..854 CDD:238001 19/108 (18%)
CUB 857..963 CDD:238001 21/121 (17%)
CUB 1066..1179 CDD:238001 19/126 (15%)
CUB 1185..1293 CDD:238001 32/121 (26%)
CUB 1303..1406 CDD:238001 18/112 (16%)
CUB 1411..1523 CDD:238001 17/111 (15%)
CUB 1530..1648 CDD:238001 23/133 (17%)
CUB 1754..1862 CDD:238001 13/75 (17%)
CUB 1979..2091 CDD:238001
CUB 2210..2321 CDD:238001
CUB 2327..2441 CDD:238001
CUB 2688..2782 CDD:412131
CUB 2810..2911 CDD:238001
CUB 3029..3143 CDD:238001
CUB 3169..3249 CDD:412131
CUB 3499..3607 CDD:238001
NNP_476859.2 EGF_CA 179..214 CDD:238011 18/35 (51%)
EGF_CA 217..252 CDD:238011 16/40 (40%)
EGF_CA 260..291 CDD:238011 9/42 (21%)
EGF_CA 295..329 CDD:238011 11/36 (31%)
EGF_CA 331..369 CDD:238011 20/40 (50%)
EGF_CA 449..486 CDD:238011 6/39 (15%)
EGF_CA 488..524 CDD:238011 13/37 (35%)
EGF_CA 526..562 CDD:238011 14/36 (39%)
EGF_CA 564..600 CDD:238011 7/37 (19%)
EGF_CA 602..637 CDD:238011 9/50 (18%)
EGF_CA 640..675 CDD:238011 9/48 (19%)
EGF_CA 677..713 CDD:238011 12/39 (31%)
EGF_CA 715..750 CDD:238011 8/37 (22%)
EGF_CA 753..789 CDD:238011 8/44 (18%)
EGF_CA 791..827 CDD:238011 7/48 (15%)
EGF_CA 829..865 CDD:238011 12/57 (21%)
EGF_CA 907..943 CDD:238011 10/40 (25%)
EGF_CA 946..982 CDD:238011 7/36 (19%)
EGF_CA 984..1020 CDD:238011 15/82 (18%)
EGF_CA 1027..1058 CDD:238011 9/68 (13%)
EGF_CA 1062..1095 CDD:238011 11/50 (22%)
EGF_CA 1184..1219 CDD:238011 12/51 (24%)
EGF_CA 1221..1257 CDD:238011 8/43 (19%)
EGF_CA 1259..1295 CDD:238011 12/82 (15%)
EGF_CA 1297..1335 CDD:238011 6/43 (14%)
EGF_CA 1338..1373 CDD:238011 9/34 (26%)
EGF_CA 1417..1450 CDD:238011 4/32 (13%)
NL 1476..1512 CDD:197463 10/39 (26%)
Notch 1519..1553 CDD:459658 7/54 (13%)
Notch 1565..1593 CDD:459658 9/66 (14%)
NOD 1598..1652 CDD:462014 3/5 (60%)
NODP 1679..1731 CDD:462229
JMTM_dNotch 1719..1806 CDD:411989
ANK repeat 1902..1948 CDD:293786
ANKYR 1936..2139 CDD:440430
ANK repeat 1951..1981 CDD:293786
ANK repeat 1984..2015 CDD:293786
ANK repeat 2017..2048 CDD:293786
ANK repeat 2050..2081 CDD:293786
ANK repeat 2083..2114 CDD:293786
Blue background indicates that the domain is not in the aligned region.

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