DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42255 and Adgrg6

DIOPT Version :9

Sequence 1:	NP_729748.3	Gene:	CG42255 / 39334	FlyBaseID:	FBgn0259140	Length:	3613	Species:	Drosophila melanogaster
Sequence 2:	XP_218313.7	Gene:	Adgrg6 / 308376	RGDID:	1308551	Length:	1248	Species:	Rattus norvegicus

Alignment Length:	964	Identity:	187/964 - (19%)
Similarity:	308/964 - (31%)	Gaps:	369/964 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly  1066 CG----------GTFTARFGYIKSPNWPKNYGESQMCEWILRAPFGHRIELVVHNFTLEEEYSST 1120
            ||          ||||       ||.:|.:|..:|.|.|.||||.|:.|::..::|.:||   :.
  Rat    38 CGNCRLVLSNPSGTFT-------SPCYPNDYPNTQSCSWTLRAPTGYIIQITFNDFDIEE---AP 92

  Fly  1121 GCWTDWLEIRNGDSESSPLIGRYCGNEIPSRIPSFG---NVLHLKFKSDDSMEEKGFLLSWQQMG 1182
            .|..|.|.:.||:|::     ::||  ..::..||.   |.:|:.|.||.|:::|||..|:
  Rat    93 NCIYDSLSLDNGESQT-----KFCG--ATAKGLSFNSSVNEMHVSFSSDFSIQKKGFNASY---- 146

  Fly  1183 AGCGGKLSSSMGTIHSPHLLAGNRGILACDWQIIVAEGSRVSLQLRSNDNRICSGQLTLYDGPTT 1247
                                                  .||::.|| |...|....|..|
  Rat   147 --------------------------------------IRVAVSLR-NQKVILPQTLDAY----- 167

  Fly  1248 ASNPIVIRCNGTIAKPLQSTGNRVLVRYDVGHDAPDGTDFMLNYQTNCRVRLEGLQGAIETPNFP 1312
                     ..::||.:               ..|:...|.|.::            |.:..|
  Rat   168 ---------QVSVAKSI---------------SIPELKAFTLCFE------------ASKVGN-- 194

  Fly  1313 ENYPPGQDCEWDIRAGGRKNHLQLIFSHLSVEK-----FSSI----C-LNDYVSLVDMLDDQTLS 1367
                  :|.:|...:...|:..||    ||:||     |.||    | ||:.:.:.:..|..|.:
  Rat   195 ------EDDDWTAFSYSDKSLTQL----LSLEKANNGYFLSISGARCLLNNALPVKEKEDIFTGN 249

  Fly  1368 EQHLCTNDGLEPITTVGNRLLLRFKSDSSVELQGFRAEYKRIGCGEHLRESGGRFESPNAPFSVD 1432
            .:.||               |:...|..||.: .|:..|:.|.|.
  Rat   250 FEQLC---------------LVWNNSWGSVGI-NFKKNYETIPCD-------------------- 278

  Fly  1433 MDCVWIITASEGNQIRLLLHEVYFEAPQIECRDAESSLSVSAPSGYNSSVVLFRSCHEETQTQTF 1497
               :.|.|...|:...||..:          ||..:||..|.   ||..:..|....:.....:.
  Rat   279 ---LTIGTVVPGDGTLLLGSD----------RDEIASLKGSV---YNFRLWNFTMDPKSLSNLSC 327

  Fly  1498 TSPGNELVI----RFVSSSAPSRKYFKASFVQVPASCGGYI------------------------ 1534
            :..||  ||    .|.|.|..:.|      .:...|||.|:
  Rat   328 SMSGN--VIDWHNDFWSISTQALK------AENNLSCGSYLIPLPAAELTNCSDLGTLCQATVSP 384

  Fly  1535 -SASSGVLTT--PGFHNHQDSKN----------VANYTSNIECVWTVEVTNGYGIRPHFEQFNLT 1586
             :..|.::||  |..:..:..||          :.|..::.|.  .|:......:...|:.:|.|
  Rat   385 PTPPSPIVTTNIPVTNRIRKQKNDGIMYRISVVIHNDLNHPEV--RVQSKVAEWLNATFQNWNYT 447

  Fly  1587 DSGNCSVSFVELTKLEPDNKEIFLEKTCGEDSPMIR---------------IVHGRKLRVRFKSQ 1636
                  |..|.::          ..:..|||...::               :|:.....|....:
  Rat   448 ------VYVVNIS----------FHQDLGEDRMKVKRDVMDDDKRLVLWALLVYNATNNVSLNGE 496

  Fly  1637 AGTWGRFIMYFERQCGGRLSTGEGYLQSRLDEE----CSWLVTSPEGSKLSLI---INQLECPK- 1693
                    |..::......|..:|....::|.:    |:.| ..|||.|.:.|   :.:..||.
  Rat   497 --------MIEQKLSANNASLEDGIRLCKVDVKQLGMCNTL-GDPEGFKWTAISPSVYKQPCPNK 552

  Fly  1694 ----------CNAVS--------QNCS--------EGLQLLNDDDQVLLYQMCRDHPANLIVPAN 1732
                      ||..|        .|||        |.|.|..|...              :..||
  Rat   553 PGFFMMRTCLCNETSTFWGPIDASNCSRQSNEVANEILDLTGDGQN--------------LTSAN 603

  Fly  1733 NVRILTHGIRLQAQFSTFENSCGGNITSASGSLSSPNYPDSYPANIECVWSIRTRPGNALEITFE 1797
            ...|:....|:..:....:.:.|..:.:...::.|.:..:...::.|.:.:|.       |:.|:
  Rat   604 INSIVEQVKRIVNKEENIDRTLGSTLMNIFSNILSSSDSNLLESSTEALKTID-------ELAFK 661

  Fly  1798 AMDIVRSEHCNDDFLEIRSSVQGPLLALYCDKNLPETPLVVHSELWIKFRSRPGNTAGGFRFRWT 1862
             :|:..:.|.|         ::...|||.....:|.|....:..:.:     |.|....|:..:.
  Rat   662 -IDLNSTPHVN---------IETQNLALGVSSLMPGTNAPSNFSIGL-----PSNNDSYFQMDFE 711

  Fly  1863 YVHNNEINSGINGTIEP------PPPLF--VSNEDQPFTWRL-FTDFKKVFVLQ 1907
                       ||..:|      ||.|.  :|.||.....|. ||.|.|..:.|
  Rat   712 -----------NGQADPLASVILPPNLLENLSPEDSILVRRAQFTFFNKTGLFQ 754

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42255	NP_729748.3	EGF_CA	156..190	CDD:238011
		EGF_CA	192..233	CDD:238011
		EGF_CA	290..328	CDD:214542
		EGF_CA	330..374	CDD:214542
		EGF	427..455	CDD:278437
		EGF_CA	462..496	CDD:238011
		CUB	503..619	CDD:238001
		CUB	624..738	CDD:238001
		CUB	745..854	CDD:238001
		CUB	857..963	CDD:238001
		CUB	1066..1179	CDD:238001	42/125 (34%)
		CUB	1185..1293	CDD:238001	13/107 (12%)
		CUB	1303..1406	CDD:238001	26/112 (23%)
		CUB	1411..1523	CDD:238001	22/115 (19%)
		CUB	1530..1648	CDD:238001	23/169 (14%)
		CUB	1754..1862	CDD:238001	17/107 (16%)
		CUB	1979..2091	CDD:238001
		CUB	2096..2193	CDD:294042
		CUB	2210..2321	CDD:238001
		CUB	2327..2441	CDD:238001
		CUB	2688..2782	CDD:294042
		CUB	2810..2911	CDD:238001
		CUB	3029..3143	CDD:238001
		CUB	3169..3249	CDD:294042
		CUB	3499..3607	CDD:238001
Adgrg6	XP_218313.7	CUB	38..146	CDD:238001	41/124 (33%)
		LamG	178..337	CDD:304605	49/236 (21%)
		GPS	799..844	CDD:280071
		7tm_4	861..1108	CDD:304433
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3714
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900