DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42255 and LRP12

DIOPT Version :9

Sequence 1:	NP_729748.3	Gene:	CG42255 / 39334	FlyBaseID:	FBgn0259140	Length:	3613	Species:	Drosophila melanogaster
Sequence 2:	NP_038465.1	Gene:	LRP12 / 29967	HGNCID:	31708	Length:	859	Species:	Homo sapiens

Alignment Length:	420	Identity:	100/420 - (23%)
Similarity:	156/420 - (37%)	Gaps:	120/420 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly  1065 SCGGT---FTARFGYIKSPNWPKNYGESQMCEWILRAPFGHRIELVVHNFTLEEEYSSTGCWTDW 1126
            :||.|   ..|..|.|.||.||..|.....|.|.:||..|..|.:...:|.::   .|..|..||
Human    46 ACGETPEQIRAPSGIITSPGWPSEYPAKINCSWFIRANPGEIITISFQDFDIQ---GSRRCNLDW 107

  Fly  1127 LEI---RNGDSESSPLIGRYCGNEIPSRIPSFGNVLHLKFKSDDSMEEKGFLLSWQQMGAGCGGK 1188
            |.|   :|.:|.      |.||:.||....|..:.:.::|.|||::..|||             :
Human   108 LTIETYKNIESY------RACGSTIPPPYISSQDHIWIRFHSDDNISRKGF-------------R 153

  Fly  1189 LSSSMGTIHSPHLLAGNRGILACDWQIIVAEGSRVSLQLR---------SNDNRICSGQLTLYDG 1244
            |:...|....|:        .||| |.....|..:....:         |:|..||:.:.   :.
Human   154 LAYFSGKSEEPN--------CACD-QFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEA---NP 206

  Fly  1245 PTTAS---------------------NPIVIRCNGTIAKPLQSTGNRVLVRYDVGHDAPDGTDFM 1288
            ||.|:                     .|..::|:|.|  .....|:      ::..|.|
Human   207 PTAAAFQPCAYNQFQCLSRFTKVYTCLPESLKCDGNI--DCLDLGD------EIDCDVP------ 257

  Fly  1289 LNYQTNCRVRLEGLQGAIETPNFPENYPPGQDCEWDIRAGGRKNHLQLIFSHLSVEKFSSICLN- 1352
                 .|...|:...|...:||:|:.||||.:|.|.|..|   :|.::|.      :|:...|:
Human   258 -----TCGQWLKYFYGTFNSPNYPDFYPPGSNCTWLIDTG---DHRKVIL------RFTDFKLDG 308

  Fly  1353 ----DYVSLVDMLDDQTLSEQHLCTN-DGLEPITTVGN--RLLLRFKSDSSVELQGFRAEYK--- 1407
                |||.:.|.|::.......:.|. |...|:|.|.:  ::.:.|.:|.....:||.|.|:
Human   309 TGYGDYVKIYDGLEENPHKLLRVLTAFDSHAPLTVVSSSGQIRVHFCADKVNAARGFNATYQVDG 373

  Fly  1408 -----------RIGCGEHLRESGGRFESPN 1426
                       ..||....:...|.:..||
Human   374 FCLPWEIPCGGNWGCYTEQQRCDGYWHCPN 403

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42255	NP_729748.3	EGF_CA	156..190	CDD:238011
		EGF_CA	192..233	CDD:238011
		EGF_CA	290..328	CDD:214542
		EGF_CA	330..374	CDD:214542
		EGF	427..455	CDD:278437
		EGF_CA	462..496	CDD:238011
		CUB	503..619	CDD:238001
		CUB	624..738	CDD:238001
		CUB	745..854	CDD:238001
		CUB	857..963	CDD:238001
		CUB	1066..1179	CDD:238001	39/118 (33%)
		CUB	1185..1293	CDD:238001	22/137 (16%)
		CUB	1303..1406	CDD:238001	31/110 (28%)
		CUB	1411..1523	CDD:238001	4/16 (25%)
		CUB	1530..1648	CDD:238001
		CUB	1754..1862	CDD:238001
		CUB	1979..2091	CDD:238001
		CUB	2096..2193	CDD:294042
		CUB	2210..2321	CDD:238001
		CUB	2327..2441	CDD:238001
		CUB	2688..2782	CDD:294042
		CUB	2810..2911	CDD:238001
		CUB	3029..3143	CDD:238001
		CUB	3169..3249	CDD:294042
		CUB	3499..3607	CDD:238001
LRP12	NP_038465.1	CUB	47..158	CDD:238001	40/132 (30%)
		LDLa	166..200	CDD:238060	7/34 (21%)
		LDLa	215..254	CDD:238060	5/46 (11%)
		CUB	267..371	CDD:238001	32/112 (29%)
		LDLa	375..410	CDD:238060	5/29 (17%)
		LDLa	413..448	CDD:238060
		LDLa	451..485	CDD:238060
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	623..678
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	693..723
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	748..770
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	801..823
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910