DRSC/TRiP Functional Genomics Resources

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Protein Alignment Cubn2 and Jag2

DIOPT Version :10

Sequence 1:NP_729748.3 Gene:Cubn2 / 39334 FlyBaseID:FBgn0259140 Length:3613 Species:Drosophila melanogaster
Sequence 2:NP_001401828.1 Gene:Jag2 / 29147 RGDID:2938 Length:1247 Species:Rattus norvegicus


Alignment Length:740 Identity:184/740 - (24%)
Similarity:251/740 - (33%) Gaps:279/740 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly   154 ARNECLSNPCKNGGTCHDAYKGFQCECPAGWQGDSCEDDVNECFT----LAGT---DLDG----- 206
            |.:.|.||||.|||:||:...||:|.||:||.|.:|..|::||.:    ..||   .:||     
  Rat   347 AEHACASNPCANGGSCHEVLSGFECHCPSGWSGPTCALDIDECASNPCAAGGTCVDQVDGFECIC 411

  Fly   207 --------------------CLNNGQCINTPGSYRCVCRNGFTGTHCRLRHNTCLFGGSRELCGE 251
                                |||...|.|..|.|.|.|..|:.|.:|.:..|.|     ...|..
  Rat   412 PEQWVGATCQLDANECEGKPCLNAFSCKNLIGGYYCDCLPGWKGANCHININDC-----HGQCQH 471

  Fly   252 HGTCIQAANSAGYVCICDQGWTWADANV----TSASP------------------------SACV 288
            .|||....|  ||.|:|.:|:......:    .::||                        ..|.
  Rat   472 GGTCKDLVN--GYQCVCPRGFGGRHCELEYYKCASSPCRRGGICEDLVDGFRCHCPRGLSGPLCE 534

  Fly   289 RDVDECEPRVNPC---------------------------------------------------- 301
            .|||.|||  |||                                                    
  Rat   535 VDVDLCEP--NPCLNGARCYNLEDDYYCACPEDFGGKNCSVPRETCPGGACRVIDGCGFEAGSRA 597

  Fly   302 -----------HDECINLP-GSFRCGACPTGYTGDGRFCRD-IDECASED--NGGCSLQPRVTCT 351
                       |..|::|| |:|.| .|.:|:|  |.:|.: ||:|..:.  |||       ||.
  Rat   598 HGAAPSGVCGPHGHCVSLPGGNFSC-ICDSGFT--GTYCHENIDDCMGQPCRNGG-------TCI 652

  Fly   352 NTEGSHRCGRCPAGWTGDGRTCTASDSNSCNNEGICHPLAKC-EYVSDMVVCTCPLGSFGHGYGA 415
            :...|.|| .||:||  :|..|.. :.|.|..:. ||...:| :.|:|. .|.|       ..|.
  Rat   653 DEVDSFRC-FCPSGW--EGELCDI-NPNDCLPDP-CHSRGRCYDLVNDF-YCVC-------DDGW 704

  Fly   416 DGCSADSSRLPCDQHPCQNNGTCVQNGRGTTCICQPGYSGVVC----NSSDACHPSPCLNGGTCR 476
            .|.:..|....||.:.|.|.|||..:|....|.|.||:.|..|    |||  |.|:||:|||||.
  Rat   705 KGKTCHSREFQCDAYTCSNGGTCYDSGDTFRCACPPGWKGSTCTIAKNSS--CVPNPCVNGGTCV 767

  Fly   477 LLPDAKYQCVCPRGYTGTTCSHQRFFC--------GVTIRGPSG-QLHYPPNTADGDYQAD-ERC 531
            ...|: :.|:|..|:.|.||:|....|        |:.:.|.:. :....|..|..|.:.: :.|
  Rat   768 GSGDS-FSCICRDGWEGRTCTHNTNDCNPLPCYNGGICVDGVNWFRCECAPGFAGPDCRINIDEC 831

  Fly   532 PFIIRTNRNMVLNLTFTQFQLEDSADCTADFLQLHDGNSLSSRLIGRFCGSRLPMTNGSVITTQE 596
                                  .|:.|..       |.:....:.|..| |..|..:|.  ..||
  Rat   832 ----------------------QSSPCAY-------GATCVDEINGYRC-SCPPGRSGP--RCQE 864

  Fly   597 QVFF----WFRSDNQTQGKGF----------------HVIWNSLPFSCGETINLTSTQTGVLRSP 641
            .|.|    |.|..:...|..:                ..:|      ||....|.|.|...|.:.
  Rat   865 VVIFTRPCWSRGVSFPHGSSWVEDCNSCRCLDGHRDCSKVW------CGWKPCLLSPQPSALSAQ 923

  Fly   642 GYPGQARPELDCRWQLTAPFGYRLLLRFYDISLGSSEASAGNCSQDSLIVYDSDRQLLRACQSIQ 706
            ..|||     .||                       |.:.|.|.|.....:..       |.:..
  Rat   924 CPPGQ-----QCR-----------------------EKAMGQCLQPPCENWGE-------CTAED 953

  Fly   707 P-PP--------VYSSSNSLRLDFH 722
            | ||        .:..:|..||..|
  Rat   954 PLPPSTPCLPRTTHLDNNCARLTLH 978

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Cubn2NP_729748.3 cubilin_NTD 38..141 CDD:412063
EGF_CA 156..190 CDD:238011 18/33 (55%)
EGF_CA 192..233 CDD:238011 18/72 (25%)
EGF_CA 290..328 CDD:214542 20/101 (20%)
EGF_CA 330..374 CDD:214542 16/46 (35%)
EGF 427..455 CDD:394967 12/27 (44%)
EGF_CA 462..496 CDD:238011 14/33 (42%)
CUB 503..619 CDD:238001 23/145 (16%)
CUB 624..738 CDD:238001 23/108 (21%)
CUB 745..854 CDD:238001
CUB 857..963 CDD:238001
CUB 1066..1179 CDD:238001
CUB 1185..1293 CDD:238001
CUB 1303..1406 CDD:238001
CUB 1411..1523 CDD:238001
CUB 1530..1648 CDD:238001
CUB 1754..1862 CDD:238001
CUB 1979..2091 CDD:238001
CUB 2210..2321 CDD:238001
CUB 2327..2441 CDD:238001
CUB 2688..2782 CDD:412131
CUB 2810..2911 CDD:238001
CUB 3029..3143 CDD:238001
CUB 3169..3249 CDD:412131
CUB 3499..3607 CDD:238001
Jag2NP_001401828.1 MNNL 28..196 CDD:462222
DSL 178..240 CDD:128366
EGF_CA 307..345 CDD:238011
EGF 351..381 CDD:394967 18/29 (62%)
EGF_CA 385..421 CDD:238011 7/35 (20%)
EGF_CA 423..458 CDD:238011 11/34 (32%)
EGF_CA 461..496 CDD:238011 12/41 (29%)
EGF_CA 502..534 CDD:238011 2/31 (6%)
EGF_CA 536..571 CDD:238011 9/36 (25%)
EGF_CA 636..671 CDD:238011 16/44 (36%)
EGF_CA 676..709 CDD:238011 11/41 (27%)
EGF 716..746 CDD:394967 13/29 (45%)
EGF_CA 757..787 CDD:238011 14/30 (47%)
EGF_CA <797..824 CDD:238011 4/26 (15%)
EGF_CA 827..863 CDD:238011 9/67 (13%)
VWC_out 872..943 CDD:214565 19/104 (18%)
Blue background indicates that the domain is not in the aligned region.

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