DRSC/TRiP Functional Genomics Resources

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Protein Alignment Cubn2 and DCBLD1

DIOPT Version :10

Sequence 1:NP_729748.3 Gene:Cubn2 / 39334 FlyBaseID:FBgn0259140 Length:3613 Species:Drosophila melanogaster
Sequence 2:NP_001353387.1 Gene:DCBLD1 / 285761 HGNCID:21479 Length:715 Species:Homo sapiens


Alignment Length:750 Identity:150/750 - (20%)
Similarity:246/750 - (32%) Gaps:249/750 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly  1741 IRLQAQFSTFENSCGGNIT-SASGSLSSPNYPDSYPANIECVWSIRTRPGNALEITFEAMDIVRS 1804
            :||||:  ...:.||..:| ..||:::|.|||.:||.:..|..:|....|..|.:....:|| .|
Human    30 LRLQAE--ELGDGCGHLVTYQDSGTMTSKNYPGTYPNHTVCEKTITVPKGKRLILRLGDLDI-ES 91

  Fly  1805 EHCNDDFLEIRSSVQ--GPLLALYC-DKNLPETPLVVHSELWIKFRSRPGNTAGGFRFRWTYVHN 1866
            :.|..|:|...||..  ||    || ...:|:..|:..||:.::|.|  |:...|..|..||..:
Human    92 QTCASDYLLFTSSSDQYGP----YCGSMTVPKELLLNTSEVTVRFES--GSHISGRGFLLTYASS 150

  Fly  1867 NEINSGINGTIEPPPPLFVSNEDQPFTWRLFTDFKKVFVLQFEEY---ISGLILFDGYDDNAL-- 1926
            :.            |.|....|..  :..|.|::.|.......:.   |||.:: |||.|.:|  
Human   151 DH------------PDLITCLERA--SHYLKTEYSKFCPAGCRDVAGDISGNMV-DGYRDTSLLC 200

  Fly  1927 --AVNIPVSPWRFTSSSNVVYLKTVNDALTHFR--LKWGVL--DSNLVASNLSLTTGGCTKELTL 1985
              |::..:.........:|:..|    .::.:.  |..|||  |.:|.......|:.||::.|:.
Human   201 KAAIHAGIIADELGGQISVLQRK----GISRYEGILANGVLSRDGSLSDKRFLFTSNGCSRSLSF 261

  Fly  1986 SHHGDIELSS-------------------------PGYPHGYAPNLN--CEW------------- 2010
            ...|.|..||                         |.:..|.:.|.:  .||             
Human   262 EPDGQIRASSSWQSVNESGDQVHWSPGQARLQDQGPSWASGDSSNNHKPREWLEIDLGEKKKITG 326

  Fly  2011 --TIRSQFPSHHIYAHSIIVDLED---------------------------------YPACSADY 2040
              |..|...:.:.|..|.:::.::                                 .|...|.|
Human   327 IRTTGSTQSNFNFYVKSFVMNFKNNNSKWKTYKGIVNNEEKVFQGNSNFRDPVQNNFIPPIVARY 391

  Fly  2041 LSI--QSSRDLIKWKNELHACKASQIAPVHGTPYLRLQFRSDVSINGTGFRAKLRTSCGSNMT-- 2101
            :.:  |:....|..|.||..|:.:|                     |.......:||..::::  
Human   392 VRVVPQTWHQRIALKVELIGCQITQ---------------------GNDSLVWRKTSQSTSVSTK 435

  Fly  2102 ----GIVGTIPQENLFDECAWHIDVRPGRKIDIAINYNNMPPIAVCEAYGLIYDGVDEHASLLEH 2162
                .|...||.|    |.:..|::     ..:||      |:.:...  |::.|:...|:..:.
Human   436 KEDETITRPIPSE----ETSTGINI-----TTVAI------PLVLLVV--LVFAGMGIFAAFRKK 483

  Fly  2163 TRFGNQMGIRRTQFRTSGSHAYIKYHIGRSRINGLCLWNLTYREFNECNGEIQL------NQQAP 2221
            .:.|:..|....|  .:.....|||...|.:   ...:.::|....|...::.|      :.|.|
Human   484 KKKGSPYGSAEAQ--KTDCWKQIKYPFARHQ---SAEFTISYDNEKEMTQKLDLITSDMADYQQP 543

  Fly  2222 ----NYTIMSPGYPYLPHP--------------HAECTW--------LVMAPPGETIAVDFDEQF 2260
                ..|:...|..:.|..              |.:|..        |.:|||....|....|:.
Human   544 LMIGTGTVTRKGSTFRPMDTDAEEAGVSTDAGGHYDCPQRAGRHEYALPLAPPEPEYATPIVERH 608

  Fly  2261 ELSARHCDKENVEFFDGATKLARLLLRTCRKPQNTVRTTGNLLLVHYQSQLNEPTGGFRLNLSLS 2325
            .|.|.                       ....|:..|..|             |..|.:.:||  
Human   609 VLRAH-----------------------TFSAQSGYRVPG-------------PQPGHKHSLS-- 635

  Fly  2326 TCGGQFSASAGFISSE-NY--PHLG-----GYPKP 2352
              .|.||..||..:.: :|  ||..     ||.:|
Human   636 --SGGFSPVAGVGAQDGDYQRPHSAQPADRGYDRP 668

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Cubn2NP_729748.3 cubilin_NTD 38..141 CDD:412063
EGF_CA 156..190 CDD:238011
EGF_CA 192..233 CDD:238011
EGF_CA 290..328 CDD:214542
EGF_CA 330..374 CDD:214542
EGF 427..455 CDD:394967
EGF_CA 462..496 CDD:238011
CUB 503..619 CDD:238001
CUB 624..738 CDD:238001
CUB 745..854 CDD:238001
CUB 857..963 CDD:238001
CUB 1066..1179 CDD:238001
CUB 1185..1293 CDD:238001
CUB 1303..1406 CDD:238001
CUB 1411..1523 CDD:238001
CUB 1530..1648 CDD:238001
CUB 1754..1862 CDD:238001 36/111 (32%)
CUB 1979..2091 CDD:238001 26/188 (14%)
CUB 2210..2321 CDD:238001 21/142 (15%)
CUB 2327..2441 CDD:238001 10/33 (30%)
CUB 2688..2782 CDD:412131
CUB 2810..2911 CDD:238001
CUB 3029..3143 CDD:238001
CUB 3169..3249 CDD:412131
CUB 3499..3607 CDD:238001
DCBLD1NP_001353387.1 CUB 41..149 CDD:238001 38/114 (33%)
LCCL 156..238 CDD:445888 18/88 (20%)
FA58C 260..411 CDD:238014 21/150 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 278..312 3/33 (9%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 619..702 16/66 (24%)
Blue background indicates that the domain is not in the aligned region.

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