Protein Alignment Cubn2 and Cdcp2

DIOPT Version :10

• Sequence 1: NP_729748.3
• Gene: Cubn2 / 39334
• FlyBaseID: FBgn0259140
• Length: 3613
• Species: Drosophila melanogaster
• Sequence 2: XP_030109426.1
• Gene: Cdcp2 / 242603
• MGIID: 3045328
• Length: 540
• Species: Mus musculus
• Alignment Length: 581
• Identity: 125/581 - (21%)
• Similarity: 199/581 - (34%)
• Gaps: 160/581 - (27%)

  Fly  1066 CGGTFTARFGYIKSPNWPKNYGESQMCEWILRAPFGHRIELVVHNFTLEEEYSSTGCWTDWLEIR 1130
            |||..:|..|...|||:|..|..:..|.|::....|..:.|..|.|.|  ||..| |..|:|||.
Mouse    30 CGGVLSAPSGNFSSPNFPSLYPYNTECSWLIVVAEGSSVLLTFHAFDL--EYHDT-CGFDFLEIY 91

  Fly  1131 NGDS-ESSPLIGRYCGNEIPSRIPSFGNVLHLKFKSDDSMEEKGFLLSWQQMGAGCGGKLSSSMG 1194
            ||.| :...|:||:||...|....|..:|:.:.|.||..:..:||...:|:
Mouse    92 NGASGDKGNLLGRFCGQVPPPPFTSSWHVMSVVFHSDKHVASRGFSAGYQK-------------- 142

  Fly  1195 TIHSPHLLAGNRGILACDWQIIVAEGSRVSLQLRSNDNRICSGQLTLYDGPTTASNPIVIRCNGT 1259
                                                  .:|.|.||
Mouse   143 --------------------------------------DVCGGVLT------------------- 150

  Fly  1260 IAKPLQSTGNRVLVRYDVGHDAPDGTDFMLNYQTNCRVRLEGLQGAIETPNFPENYPPGQDCEWD 1324
                                                     ||.|.:.:|.:|.|||...:|.|.
Mouse   151 -----------------------------------------GLSGVLSSPEYPNNYPNNVECHWL 174

  Fly  1325 IRAGGRKNHLQLIFSHLSVEKFSSICLNDYVSLVDMLDDQTLSEQHLCTNDGLEPITTVGNRLLL 1389
            |||.| ...::|:|....||. |..|:.|||:::..  .......|.|.........::|:.|.:
Mouse   175 IRASG-PAAVKLVFVDFQVEG-SDECMYDYVAVLGA--PGPAHGHHYCGRTRPPTFVSLGHELQV 235

  Fly  1390 RFKSDSSVELQGFRAEYKRIGCGEHLRESGGRFESPNAP--FSVDMDCVWIITASEGNQIRLLLH 1452
            .||||.::..:||:|.|....|.|......|.|.||..|  :..::.|.|.|....|.::::.:.
Mouse   236 VFKSDFNIGGRGFKAHYFSGECQEVFTAVRGNFSSPQYPGAYPNNIRCHWTIRLPPGYRVKVFIL 300

  Fly  1453 EVYFEAPQIECRDAESSLSVSAPSGYNSSVVLFRSCHEETQTQTFTSPGNELVIRFVSSSAPSRK 1517
            ::..|.|....|..:.....:.......:.:|.:.|........ ||..|::::...:..:.|.:
Mouse   301 DLGLEEPNSLTRTCDFDHLAAFDGASEEAQLLGKWCGHHLPPPV-TSSRNQVLLLLHTDRSTSGR 364

  Fly  1518 YFKASFVQV---PASCGG-----YISASSGVLTTPGFHNHQDSKNVANYTSNIECVWTVEVTNGY 1574
            .|..:::.|   ..||..     .|||.:   ..|       .:....|..:..|. ..||.:.:
Mouse   365 GFSVAYIGVVPMNVSCSRTDFQILISAQA---LAP-------LERTKVYLGSRSCA-AQEVGSNF 418

  Fly  1575 GIRPHFE------QFNLTDSGNCSVSFVELT------------KLEPDNKEIFLEKTCGED 1617
            .|:..|:      |.....|...||.:::.:            :.||..||.......|.|
Mouse   419 RIQARFDTCGTESQRRNNTSVIVSVLYIDFSTAGHDDIHEYEVRCEPRRKEASAHLLSGSD 479

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cubn2	NP_729748.3	cubilin_NTD	38..141	CDD:412063
		EGF_CA	156..190	CDD:238011
		EGF_CA	192..233	CDD:238011
		EGF_CA	290..328	CDD:214542
		EGF_CA	330..374	CDD:214542
		EGF	427..455	CDD:394967
		EGF_CA	462..496	CDD:238011
		CUB	503..619	CDD:238001
		CUB	624..738	CDD:238001
		CUB	745..854	CDD:238001
		CUB	857..963	CDD:238001
		CUB	1066..1179	CDD:238001	41/113 (36%)
		CUB	1185..1293	CDD:238001	4/107 (4%)
		CUB	1303..1406	CDD:238001	32/102 (31%)
		CUB	1411..1523	CDD:238001	21/113 (19%)
		CUB	1530..1648	CDD:238001	21/111 (19%)
		CUB	1754..1862	CDD:238001
		CUB	1979..2091	CDD:238001
		CUB	2210..2321	CDD:238001
		CUB	2327..2441	CDD:238001
		CUB	2688..2782	CDD:412131
		CUB	2810..2911	CDD:238001
		CUB	3029..3143	CDD:238001
		CUB	3169..3249	CDD:412131
		CUB	3499..3607	CDD:238001
Cdcp2	XP_030109426.1	CUB	30..141	CDD:238001	41/113 (36%)
		CUB	145..254	CDD:238001	39/172 (23%)
		CUB	257..370	CDD:238001	21/113 (19%)