Protein Alignment Cubn2 and nas-30

DIOPT Version :10

• Sequence 1: NP_729748.3
• Gene: Cubn2 / 39334
• FlyBaseID: FBgn0259140
• Length: 3613
• Species: Drosophila melanogaster
• Sequence 2: NP_490795.5
• Gene: nas-30 / 190803
• WormBaseID: WBGene00003548
• Length: 741
• Species: Caenorhabditis elegans
• Alignment Length: 453
• Identity: 99/453 - (21%)
• Similarity: 143/453 - (31%)
• Gaps: 174/453 - (38%)

  Fly   973 NEPGRRYVTAVRGTFCQWFIDFPGRKKISIHTLGPTPSISIYDNSTSPGKLVNSYSGSVG----- 1032
            |.||:.||...||:.|.          .|:...|.:..|||.......|.:.:....|:|
 Worm   370 NGPGKDYVIFFRGSGCY----------SSVGRTGGSQLISIGYGCEDKGIVAHEVGHSLGFWHEQ 424

  Fly  1033 ---DVFDGDLLTINLHTNWPRLEIYSIQFDIVQQDSCGGTFTAR-FGYIKSPNWPKNYGESQMCE 1093
               |..|    .|:|..:|           |::  ...|.|..| :..|:....|.:.|.
 Worm   425 SRPDRDD----YIHLRKDW-----------IIK--GTDGNFEKRSWEEIEDMGVPYDVGS----- 467

  Fly  1094 WILRAPFGHRIELVVHNFTLEEEYSSTGCWTDW--LEIRNGDSESSPLIGR-------------- 1142
                         |:|       |.|.....||  :.|...||.....||:
 Worm   468 -------------VMH-------YGSNAFTKDWDQITIETKDSRYQGTIGQRQKLSFIDVKQVNR 512

  Fly  1143 -YCGNEIPSRIPSFGNVLHLKF---------KSDDSMEEKGFLLSWQQMGAGCGGKL--SSSMGT 1195
             ||.:..|..:|    .:|..:         |..|                |.||||  .::.||
 Worm   513 LYCNSVCPVALP----CMHGGYPDPNNCAVCKCPD----------------GLGGKLCGRAAKGT 557

  Fly  1196 IHSP---HLLAG-------NRGILACDWQIIVAEGSRVSL---QLRSNDNRICSGQLTLYDGPTT 1247
            .|..   .|.|.       .:|...|:|::....|.||.|   :||..    |:.....|
 Worm   558 DHDKCGGELTATAEWQEMVYKGKRTCNWKVKSPSGGRVRLVLTELRYQ----CAPACKAY----- 613

  Fly  1248 ASNPIVIRCNGTIAKPLQSTGNRVLV---RYDVGHDAPDG--------TDFMLNYQTNCRVRLEG 1301
                |.|:.|    ...|.||.||..   .|||..|..:.        .|:.::|      :|:.
 Worm   614 ----IEIKHN----TDFQQTGFRVCCFNKTYDVISDQSEALILSNANIVDYEVSY------KLQW 664

  Fly  1302 LQG---AIETPNFPENYPPGQD------CEWDIRAGG--RKNHLQLI----FSHLSVEKFSSI 1349
            :|.   |:..|.....:.||::      .|   .:||  .|..||.|    .||..:|..:||
 Worm   665 IQDNGKALPPPKPTSTWVPGKENRPFRGVE---NSGGTIEKFILQAIPKIRDSHRPLESITSI 724

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cubn2	NP_729748.3	cubilin_NTD	38..141	CDD:412063
		EGF_CA	156..190	CDD:238011
		EGF_CA	192..233	CDD:238011
		EGF_CA	290..328	CDD:214542
		EGF_CA	330..374	CDD:214542
		EGF	427..455	CDD:394967
		EGF_CA	462..496	CDD:238011
		CUB	503..619	CDD:238001
		CUB	624..738	CDD:238001
		CUB	745..854	CDD:238001
		CUB	857..963	CDD:238001
		CUB	1066..1179	CDD:238001	24/139 (17%)
		CUB	1185..1293	CDD:238001	34/133 (26%)
		CUB	1303..1406	CDD:238001	17/62 (27%)
		CUB	1411..1523	CDD:238001
		CUB	1530..1648	CDD:238001
		CUB	1754..1862	CDD:238001
		CUB	1979..2091	CDD:238001
		CUB	2210..2321	CDD:238001
		CUB	2327..2441	CDD:238001
		CUB	2688..2782	CDD:412131
		CUB	2810..2911	CDD:238001
		CUB	3029..3143	CDD:238001
		CUB	3169..3249	CDD:412131
		CUB	3499..3607	CDD:238001
nas-30	NP_490795.5	ZnMc_astacin_like	336..514	CDD:239807	39/195 (20%)
		CUB	564..648	CDD:412131	25/100 (25%)