Protein Alignment Cubn2 and nas-21

DIOPT Version :10

• Sequence 1: NP_729748.3
• Gene: Cubn2 / 39334
• FlyBaseID: FBgn0259140
• Length: 3613
• Species: Drosophila melanogaster
• Sequence 2: NP_505907.2
• Gene: nas-21 / 188422
• WormBaseID: WBGene00003540
• Length: 380
• Species: Caenorhabditis elegans
• Alignment Length: 427
• Identity: 88/427 - (20%)
• Similarity: 152/427 - (35%)
• Gaps: 128/427 - (29%)

  Fly  1949 VNDALTHFRLKWGVLDSNLVASN---LSLTTGGC--TKELTLSHHGDIEL-SSPGYPHGYAPNLN 2007
            :|..:|.|.:...||:.....||   :.:..||.  ||.|..|....:.: :.|.:|.|
 Worm     1 MNYFITFFFMHIAVLNFYFRFSNGNKIVMRVGGSPETKRLERSKRQALRMDNEPRWPRG------ 59

  Fly  2008 CEWTIRSQFPSHHIYAHSIIVDLEDYPACSADYLSIQSSRDLIKWKNELHACKASQIAPVHGTPY 2072
               ||...|.......:|....|                |.:.|..|  |.|  .:.:|....
 Worm    60 ---TINYFFDEQRFDENSRATVL----------------RAMEKISN--HTC--IKFSPKDAR-- 99

  Fly  2073 LRLQFRSDVS-------INGTGFRAKLRTSC-----GSNMTGIVGTIPQENLFDECAW-HIDVRP 2124
            ::|:..||..       :.|........|||     .|.:..::|.:......|...: .::::|
 Worm   100 IKLRIVSDKGCQAAIGRVGGDQQYLSFPTSCYSVGSASELIHVIGFLHSHQRADRDEYLKLNLQP 164

  Fly  2125 GRKIDIAINYNNMPPIAVCEAYGLI-YDGVDEHASLLEHTRFGNQMGIRRTQ-FRTSGSH--AYI 2185
            .|..|.   :..|......:.:.:: ||    :.|::::....|:.|.:.:: |||.||.  :|.
 Worm   165 WRLNDW---FQTMQYKKYLDQWWIVPYD----YGSIMQYHDSDNEYGPKNSKYFRTMGSQIPSYF 222

  Fly  2186 KYHI----------GRSRIN---------GLCLWNLTYREFNECNGEIQLNQQAPNYTI-MSPGY 2230
            .|.:          |..:||         |.|         :|||..::.:::..|.|: :..||
 Worm   223 DYLMINEYYQCSCEGEEQINCKNRGYPNPGNC---------SECNCPLESSEEWKNITLNLDAGY 278

  Fly  2231 PYLPHPHAECTWL-----------VMAPPGETIAVDFDEQFELSARHCDKENVEFFDGATKL--- 2281
            ..|.:.    |.|           :.||..:||.||..   |::...|   |...:.|..::
 Worm   279 MSLQNG----TKLHQIDFVFRYLSISAPANKTIEVDIR---EITGVEC---NYGCYIGGIEVKTH 333

  Fly  2282 --ARLLL-RTCRKPQNTVRTTGNLLLVHYQSQLNEPT 2315
              .|:.. |.|.|..|.:          |:|: |.||
 Worm   334 EDRRMTSPRLCCKNDNEI----------YKSR-NNPT 359

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cubn2	NP_729748.3	cubilin_NTD	38..141	CDD:412063
		EGF_CA	156..190	CDD:238011
		EGF_CA	192..233	CDD:238011
		EGF_CA	290..328	CDD:214542
		EGF_CA	330..374	CDD:214542
		EGF	427..455	CDD:394967
		EGF_CA	462..496	CDD:238011
		CUB	503..619	CDD:238001
		CUB	624..738	CDD:238001
		CUB	745..854	CDD:238001
		CUB	857..963	CDD:238001
		CUB	1066..1179	CDD:238001
		CUB	1185..1293	CDD:238001
		CUB	1303..1406	CDD:238001
		CUB	1411..1523	CDD:238001
		CUB	1530..1648	CDD:238001
		CUB	1754..1862	CDD:238001
		CUB	1979..2091	CDD:238001	22/121 (18%)
		CUB	2210..2321	CDD:238001	29/124 (23%)
		CUB	2327..2441	CDD:238001
		CUB	2688..2782	CDD:412131
		CUB	2810..2911	CDD:238001
		CUB	3029..3143	CDD:238001
		CUB	3169..3249	CDD:412131
		CUB	3499..3607	CDD:238001
nas-21	NP_505907.2	ZnMc_astacin_like	59..231	CDD:239807	38/209 (18%)