DRSC/TRiP Functional Genomics Resources

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Protein Alignment Cubn2 and nas-20

DIOPT Version :10

Sequence 1:NP_729748.3 Gene:Cubn2 / 39334 FlyBaseID:FBgn0259140 Length:3613 Species:Drosophila melanogaster
Sequence 2:NP_505906.2 Gene:nas-20 / 188420 WormBaseID:WBGene00003539 Length:379 Species:Caenorhabditis elegans


Alignment Length:444 Identity:87/444 - (19%)
Similarity:144/444 - (32%) Gaps:156/444 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly   540 NMVLNLTFTQFQLEDSADCTADFLQLHDGNSLSSRLIGRFCGSRLPMTNGSVITTQEQVFFWFRS 604
            |.:.|.|..:|:..::|: ||  :::..||...| |.|...|....:|                 
 Worm    63 NYLENHTCLKFEYNENAE-TA--VRIRKGNGCYS-LYGMHAGEVQDLT----------------- 106

  Fly   605 DNQTQGKGFHVIWNSLPFSC---GETINLTSTQTGVLRSPGYPGQARPELDCRWQLTAPFGYRLL 666
                           |.::|   |..::......|:..     ||||.:.|         .|   
 Worm   107 ---------------LDYNCASFGTAVHEIMHALGIAH-----GQARSDRD---------DY--- 139

  Fly   667 LRFYDISLGSSEASAGNCSQDSLIVYDSDRQLLRA-----CQSIQPPPVYS-SSNSLRLDFHTDA 725
                 :.:.|:.::.|..:.::|:.:|....:|.|     .:.|...|.|: :..|||:.|: |.
 Worm   140 -----LIVDSTNSNDGIENTENLVPFDYGSVMLYARDPHSDKRIPIDPEYNFTMGSLRVAFY-DM 198

  Fly   726 IRSDSSFQMHYEVVPGHPGCGGVYTESRGRISGYMNFEVCLYLIEQPRGTQVKLVIDRVSLVQSL 790
            :..:..:..:.:..|....|         :..||.|          |...:..|..|.       
 Worm   199 VLLNKFYGCNCDNHPRKLDC---------KNGGYQN----------PANCEECLCTDG------- 237

  Fly   791 SCHYLKIEIFDGRSTDAPLLRRICGSHEESELEPIISIGNVIL-VRYEYALSGVRLSKSFDLTYT 854
                     |:|         ::|..||          |..:| .:.|:..||||          
 Worm   238 ---------FNG---------QLCDQHE----------GVYVLEAKKEWDASGVR---------- 264

  Fly   855 RVCTGNFNTNSGIISTPNYPGPYFDDMTCTYNLTGPLDTAVRMRITDLSLGTANNENDTSYLDVY 919
                .|:.......:.|.|  .||       .||.|..:.:.:|||.||.....:..|  |..|.
 Worm   265 ----NNYRKGIETNTMPEY--TYF-------ALTAPEGSTIEVRITKLSGFFCQHTCD--YNGVE 314

  Fly   920 LSADQKRHIVK-----STDNL---ILLSHSNRASLVFHGSGGGRGMRLEYNFVP 965
            |.....|.||.     ..|||   ...|.:|...:..:|:........||.::|
 Worm   315 LKYKTDRRIVSPLVCCDNDNLWNKTRSSTNNPFIIAKYGNNRTPHFEFEYRYIP 368

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Cubn2NP_729748.3 cubilin_NTD 38..141 CDD:412063
EGF_CA 156..190 CDD:238011
EGF_CA 192..233 CDD:238011
EGF_CA 290..328 CDD:214542
EGF_CA 330..374 CDD:214542
EGF 427..455 CDD:394967
EGF_CA 462..496 CDD:238011
CUB 503..619 CDD:238001 14/78 (18%)
CUB 624..738 CDD:238001 23/122 (19%)
CUB 745..854 CDD:238001 19/109 (17%)
CUB 857..963 CDD:238001 28/113 (25%)
CUB 1066..1179 CDD:238001
CUB 1185..1293 CDD:238001
CUB 1303..1406 CDD:238001
CUB 1411..1523 CDD:238001
CUB 1530..1648 CDD:238001
CUB 1754..1862 CDD:238001
CUB 1979..2091 CDD:238001
CUB 2210..2321 CDD:238001
CUB 2327..2441 CDD:238001
CUB 2688..2782 CDD:412131
CUB 2810..2911 CDD:238001
CUB 3029..3143 CDD:238001
CUB 3169..3249 CDD:412131
CUB 3499..3607 CDD:238001
nas-20NP_505906.2 Astacin 36..209 CDD:426242 38/204 (19%)
Blue background indicates that the domain is not in the aligned region.

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