DRSC/TRiP Functional Genomics Resources

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Protein Alignment Cubn2 and nas-29

DIOPT Version :10

Sequence 1:NP_729748.3 Gene:Cubn2 / 39334 FlyBaseID:FBgn0259140 Length:3613 Species:Drosophila melanogaster
Sequence 2:NP_494953.3 Gene:nas-29 / 186488 WormBaseID:WBGene00003547 Length:532 Species:Caenorhabditis elegans


Alignment Length:632 Identity:118/632 - (18%)
Similarity:198/632 - (31%) Gaps:249/632 - (39%)


- Green bases have known domain annotations that are detailed below.


  Fly  1012 SIYDNSTSP---GKLVNSYSGSVGDV-FDGDL--------LTINLHTNWPRLEIYSIQFDIVQQD 1064
            :||:.|..|   |||...|.    |: |:||:        :.:|..|.: |..|.|.:    :.:
 Worm    67 TIYNYSEKPISIGKLNKKYR----DILFEGDMAISYKQLSMIVNGSTEY-RKAIKSRR----RGN 122

  Fly  1065 SCGGTF---TARFGYIKSPNWPKNYGESQMC------------EWILRA-PFGHR---IELVVHN 1110
            ...|..   |.|..|:.: |:|....::.:.            ..||:| .|.:|   ||.  |.
 Worm   123 KINGESTDRTKRQAYLDN-NYPATIWKNGVAFMFHESLTPIAKTAILKAVHFWYRETCIEF--HP 184

  Fly  1111 FTLEEEY-----SSTGCWTDWLEIRNGDSESSPLIGRYCGNEIPSRIPSFGNVLHLKFKSDDSME 1170
            .|.::||     :..|||:              .:||                        |:.:
 Worm   185 RTFQKEYLLFIGNDDGCWS--------------TVGR------------------------DASQ 211

  Fly  1171 EKGFLLSWQQMGAGC------GGKLSSSMGTIHSPHLLAGNRGILACDWQIIVAEGSRVSLQLRS 1229
            .|..:    .:|.||      ..:|:.::|..|.......:        :.:|.....|...|..
 Worm   212 GKQVV----SIGNGCEHFGVTSHELAHALGIFHEQSRFDRD--------ESVVFNPRVVERDLLF 264

  Fly  1230 NDNRICSGQLTLYDGPTTASNPIVIRCNGTIAKPLQSTGNRVLVRYDVG---HDAPDGTDF---- 1287
            |..:|...|::.|..|                             ||:|   |..|  |:|    
 Worm   265 NFAKISPRQMSTYGLP-----------------------------YDIGSVMHYTP--TEFSNIP 298

  Fly  1288 ----MLNYQTNCRVRLEGLQGAIETPNFPENYPPGQDCEWDIRAGGRKNHLQLIFSHLSVEKFSS 1348
                :....||    |:...|.:|.|:|.:.:...|             |.|             
 Worm   299 SIPTLAAIDTN----LQQTMGQLEGPSFVDVHIMNQ-------------HYQ------------- 333

  Fly  1349 ICLNDYVSLVDMLDDQTLSEQHLCTNDGLEPITTVGNRLLLRFKSDSSVEL----QGFRAEYKRI 1409
             |            .:....|..|.|.|              |.:..:.::    .||...|.::
 Worm   334 -C------------QEKCPTQAPCQNGG--------------FTNSRNCKVCKCPTGFGGAYCQL 371

  Fly  1410 -------GCGEHL--RESGGRFESP--NAPFSVDMDCVWIITASEGNQIRLLLHEVYFEAPQIE- 1462
                   .||.:|  .|:..||:..  .:..:....||:.|.|.||.  |:::..:..::..|| 
 Worm   372 IASSFSPFCGGYLNAEETTRRFDITIRQSTTTRSKTCVYHIKAPEGK--RIIIDILKIDSKCIEG 434

  Fly  1463 CRDAESSLSVS---APSGYNSSVVLFRSCHEETQTQTFTSPGNELVIRFVSSSAPSRKYFKASFV 1524
            |......|.:.   .|.||       |.|..|:..:...|.||.:.....|........|:.|||
 Worm   435 CWQDGLELKMKKDFRPVGY-------RFCCPESSRRKVISEGNMVPFMVFSKEHDFSVSFEYSFV 492

  Fly  1525 QVPASCGGYISASSGVLTTPGFHNHQDSKNVANYTSNIECVWTVEVT 1571
            .                |:.||.:.::..:|  ...|::.|:..:.:
 Worm   493 S----------------TSAGFDDEKNDSDV--IVDNLDGVFVSDTS 521

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Cubn2NP_729748.3 cubilin_NTD 38..141 CDD:412063
EGF_CA 156..190 CDD:238011
EGF_CA 192..233 CDD:238011
EGF_CA 290..328 CDD:214542
EGF_CA 330..374 CDD:214542
EGF 427..455 CDD:394967
EGF_CA 462..496 CDD:238011
CUB 503..619 CDD:238001
CUB 624..738 CDD:238001
CUB 745..854 CDD:238001
CUB 857..963 CDD:238001
CUB 1066..1179 CDD:238001 24/136 (18%)
CUB 1185..1293 CDD:238001 19/124 (15%)
CUB 1303..1406 CDD:238001 15/106 (14%)
CUB 1411..1523 CDD:238001 28/119 (24%)
CUB 1530..1648 CDD:238001 6/42 (14%)
CUB 1754..1862 CDD:238001
CUB 1979..2091 CDD:238001
CUB 2210..2321 CDD:238001
CUB 2327..2441 CDD:238001
CUB 2688..2782 CDD:412131
CUB 2810..2911 CDD:238001
CUB 3029..3143 CDD:238001
CUB 3169..3249 CDD:412131
CUB 3499..3607 CDD:238001
nas-29NP_494953.3 Astacin 145..336 CDD:426242 50/316 (16%)
CUB 404..491 CDD:214483 22/95 (23%)
Blue background indicates that the domain is not in the aligned region.

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