Protein Alignment Cubn2 and nas-28

DIOPT Version :10

• Sequence 1: NP_729748.3
• Gene: Cubn2 / 39334
• FlyBaseID: FBgn0259140
• Length: 3613
• Species: Drosophila melanogaster
• Sequence 2: NP_498342.3
• Gene: nas-28 / 185658
• WormBaseID: WBGene00003546
• Length: 497
• Species: Caenorhabditis elegans
• Alignment Length: 385
• Identity: 65/385 - (16%)
• Similarity: 123/385 - (31%)
• Gaps: 153/385 - (39%)

  Fly   582 SRLPMTNGSVITTQEQVFFW-------FRSDNQTQGKGF----HVIWN------SLPF---SCGE 626
            ::|..||  :...::.:.||       |:.||..:.:.|    ...|:      .:|:   |.|.
 Worm   142 TKLSATN--IANVRKAIQFWNDNSCLSFKEDNNAKNRLFLSSAGGCWSYVGKQVDMPYQMVSVGP 204

  Fly   627 TINLTSTQT-GVLRSPGY---------------------PGQA----RPELDCRWQLTAPFGYRL 665
            ..:...|.| .::.:.|:                     |.||    :..:|....|..|:.|..
 Worm   205 NCDTFGTATHELMHAIGFWHQQSRADRDNYVYVDFSNIIPSQAYNFQKMAVDQAQLLNLPYDYGS 269

  Fly   666 LLRFYDI--------------------SLGSSEASA----------GNCSQDSLI--------VY 692
            ::::|..                    |:|..||.|          .||:....|        :.
 Worm   270 VMQYYPYAFAVDSSKYTILAKENGFQNSMGQREAPAFSDIIGVNKLYNCTSQCKIQMKCSNCGIT 334

  Fly   693 DSDRQLLRACQSIQPPPVYSSSNSLRLDFHTDAIRSDSSFQMHYEVVPGHPGCGGVYTESRGRIS 757
            ||     |.|...:.|..::.::       .|::.|.::           |.|.|...::   .|
 Worm   335 DS-----RNCNQCKCPRYFTGAS-------CDSLPSGTA-----------PNCNGAVLQA---TS 373

  Fly   758 GYMNFEV-----------------CLYLIEQPRGTQVKLVIDRVSLV---------QSLSCHYLK 796
            .:..|:.                 |.:.|:.|.|.|::..:.:..|.         ||:..:..|
 Worm   374 SWETFDAKAGDPSSFSSSTDNSTNCYWHIKAPEGQQIEFKMTKTPLAAICMQECPWQSIEVNLGK 438

  Fly   797 IEIFDGRSTDAPLLRRICGSHEESELEPIISIGNVILVRYEYALSGVRLSKSFDLTYTRV 856
            .::|...:....:|.::.    .|||..|...|   ::||.        ..:|.:.|..|
 Worm   439 FDLFGMITCCDTILNQVF----TSELNMIALRG---IIRYN--------QLTFSIQYRAV 483

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cubn2	NP_729748.3	cubilin_NTD	38..141	CDD:412063
		EGF_CA	156..190	CDD:238011
		EGF_CA	192..233	CDD:238011
		EGF_CA	290..328	CDD:214542
		EGF_CA	330..374	CDD:214542
		EGF	427..455	CDD:394967
		EGF_CA	462..496	CDD:238011
		CUB	503..619	CDD:238001	10/53 (19%)
		CUB	624..738	CDD:238001	27/177 (15%)
		CUB	745..854	CDD:238001	23/134 (17%)
		CUB	857..963	CDD:238001	65/385 (17%)
		CUB	1066..1179	CDD:238001
		CUB	1185..1293	CDD:238001
		CUB	1303..1406	CDD:238001
		CUB	1411..1523	CDD:238001
		CUB	1530..1648	CDD:238001
		CUB	1754..1862	CDD:238001
		CUB	1979..2091	CDD:238001
		CUB	2210..2321	CDD:238001
		CUB	2327..2441	CDD:238001
		CUB	2688..2782	CDD:412131
		CUB	2810..2911	CDD:238001
		CUB	3029..3143	CDD:238001
		CUB	3169..3249	CDD:412131
		CUB	3499..3607	CDD:238001
nas-28	NP_498342.3	ZnMc_astacin_like	135..316	CDD:239807	29/175 (17%)
		CUB	393..480	CDD:214483	19/101 (19%)