DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42255 and nas-24

DIOPT Version :9

Sequence 1:	NP_729748.3	Gene:	CG42255 / 39334	FlyBaseID:	FBgn0259140	Length:	3613	Species:	Drosophila melanogaster
Sequence 2:	NP_506409.2	Gene:	nas-24 / 184744	WormBaseID:	WBGene00003543	Length:	396	Species:	Caenorhabditis elegans

Alignment Length:	146	Identity:	35/146 - (23%)
Similarity:	50/146 - (34%)	Gaps:	39/146 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   163 CKNGG-----TCHDAYKGFQCECPAGWQGDSCEDDVNECFTLAGTDLDGCLNNGQCINTPGSYRC 222
            |||||     .|.      :|.||.|:.|..|    ||.......:|.......|......:|:.
Worm   237 CKNGGYTSPSDCS------RCNCPKGFFGKLC----NERRQQDSYELKATYGRWQTQTISFNYKP 291

  Fly   223 -VCRNGFTGTHCRLRHNTCLFGGSRELCGEHGTCIQAANSAGYVCICDQGWTWADANVTS----- 281
             ...:||        ::|.::     :.||..:.|:.........||..|.||....:.|
Worm   292 EPVSDGF--------YSTFVY-----ITGEANSTIEITMEGLENVICTAGCTWNGVEIKSREDSR 343

  Fly   282 -ASPSACVRDVDECEP 296
             .||..|.:|    ||
Worm   344 ITSPVMCCKD----EP 355

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42255	NP_729748.3	EGF_CA	156..190	CDD:238011	11/31 (35%)
		EGF_CA	192..233	CDD:238011	7/41 (17%)
		EGF_CA	290..328	CDD:214542	3/7 (43%)
		EGF_CA	330..374	CDD:214542
		EGF	427..455	CDD:278437
		EGF_CA	462..496	CDD:238011
		CUB	503..619	CDD:238001
		CUB	624..738	CDD:238001
		CUB	745..854	CDD:238001
		CUB	857..963	CDD:238001
		CUB	1066..1179	CDD:238001
		CUB	1185..1293	CDD:238001
		CUB	1303..1406	CDD:238001
		CUB	1411..1523	CDD:238001
		CUB	1530..1648	CDD:238001
		CUB	1754..1862	CDD:238001
		CUB	1979..2091	CDD:238001
		CUB	2096..2193	CDD:294042
		CUB	2210..2321	CDD:238001
		CUB	2327..2441	CDD:238001
		CUB	2688..2782	CDD:294042
		CUB	2810..2911	CDD:238001
		CUB	3029..3143	CDD:238001
		CUB	3169..3249	CDD:294042
		CUB	3499..3607	CDD:238001
nas-24	NP_506409.2	Astacin	49..231	CDD:279708
nas-24	NP_506409.2	ZnMc	52..227	CDD:294052
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3714
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900