DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG42255 and nas-12

DIOPT Version :9

Sequence 1:NP_729748.3 Gene:CG42255 / 39334 FlyBaseID:FBgn0259140 Length:3613 Species:Drosophila melanogaster
Sequence 2:NP_501871.2 Gene:nas-12 / 182848 WormBaseID:WBGene00003531 Length:384 Species:Caenorhabditis elegans


Alignment Length:488 Identity:93/488 - (19%)
Similarity:143/488 - (29%) Gaps:188/488 - (38%)


- Green bases have known domain annotations that are detailed below.


  Fly  2722 LSNSNGYVLEGNVTLTDRCDREYIVIFSGQSEVGRICRGMAMNSTLLERPFSTILYHS--ESRLA 2784
            :||:.....|.|..|....::|:.|.                 ..:|..|...|.|.:  :|.|:
 Worm    22 ISNAVKQSWEINQELITEANKEHTVF-----------------GDMLLTPAQLIRYENSKDSDLS 69

  Fly  2785 QQSKFI----LQAWKSVSSGNAIRIDHRPSPPVTISSKNYLESKQRIWEFVTNDGLSLRLHFLER 2845
            .:...|    :..|    |.|.  :.:..||..:.:.|..|.|..|.:|.|:      ...|:||
 Worm    70 IRGVSIKGSSMNRW----SNNI--VPYVISPQYSPAQKQILVSSLRYFERVS------CFKFVER 122

  Fly  2846 ------IFIVSSPNCSTDRLTVERYDQTTEEYIEVTSLCGRQAAN-------DILVPSARMRVIF 2897
                  :|||....|                |..|..:.|||..:       |.::....|..|.
 Worm   123 TTQNDYLFIVPLDGC----------------YSYVGKIGGRQTLSLAADCIADYIIWHEMMHAIG 171

  Fly  2898 QTNSNITGDGFSF------QVIPSCDSVLLAGAEIQTLASPSWAAFRGRQFNCSYTFYAHDNHQV 2956
            ..:.:...|..||      .|||                        |:..|......:|..:..
 Worm   172 FEHEHQRPDRDSFIRVDYANVIP------------------------GQMINFDKLKTSHVEYPD 212

  Fly  2957 VVSVRTRGRPWASYACSRSYFEAYRRGDGNGVGEESIGRLCPEFEVKGNGRVRLRYVSPL----- 3016
            :..                 |::....||...|.....|           ||||..::||     
 Worm   213 IYD-----------------FKSIMHYDGYAFGRVDTAR-----------RVRLATMTPLKPGVT 249

  Fly  3017 --------SRWFEMQYQLIQC---GGNYSTSFTLRPPQNEDSSVYAHNTLCEWRITAPPQHAVVI 3070
                    :...|...:|.||   ||.||           :..|.|  :.|:...||        
 Worm   250 LEDNMKFTATDIEKLNRLGQCGARGGQYS-----------NQGVVA--STCQDVATA-------- 293

  Fly  3071 EFKYFDMESSRNCGFDSLTIYRGHVVSEEQRTGLLCGNVTNPETIIVNSNEALIVLTTDSS---- 3131
                ...|.:|..|......|:..::...|:|..||.     .|.:::.::.|...||..|    
 Worm   294 ----VSCEGNRRRGMCKNPFYKQMMIKSCQKTCRLCS-----YTRMIDEDDDLTPNTTVKSVKCE 349

  Fly  3132 --------NSYRGFLA-----SVRF---TPNCN 3148
                    .|:.||..     .||:   ...||
 Worm   350 DKHPRCDIYSHNGFCTLPFYDDVRYQLCAKTCN 382

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG42255NP_729748.3 EGF_CA 156..190 CDD:238011
EGF_CA 192..233 CDD:238011
EGF_CA 290..328 CDD:214542
EGF_CA 330..374 CDD:214542
EGF 427..455 CDD:278437
EGF_CA 462..496 CDD:238011
CUB 503..619 CDD:238001
CUB 624..738 CDD:238001
CUB 745..854 CDD:238001
CUB 857..963 CDD:238001
CUB 1066..1179 CDD:238001
CUB 1185..1293 CDD:238001
CUB 1303..1406 CDD:238001
CUB 1411..1523 CDD:238001
CUB 1530..1648 CDD:238001
CUB 1754..1862 CDD:238001
CUB 1979..2091 CDD:238001
CUB 2096..2193 CDD:294042
CUB 2210..2321 CDD:238001
CUB 2327..2441 CDD:238001
CUB 2688..2782 CDD:294042 11/61 (18%)
CUB 2810..2911 CDD:238001 26/119 (22%)
CUB 3029..3143 CDD:238001 27/133 (20%)
CUB 3169..3249 CDD:294042
CUB 3499..3607 CDD:238001
nas-12NP_501871.2 Astacin 81..272 CDD:279708 50/270 (19%)
ZnMc_astacin_like 85..267 CDD:239807 45/257 (18%)
ShK 286..325 CDD:279838 9/50 (18%)
ShK 347..384 CDD:279838 7/36 (19%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3714
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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