Protein Alignment Cubn2 and Mep1b

DIOPT Version :10

• Sequence 1: NP_729748.3
• Gene: Cubn2 / 39334
• FlyBaseID: FBgn0259140
• Length: 3613
• Species: Drosophila melanogaster
• Sequence 2: NP_032612.2
• Gene: Mep1b / 17288
• MGIID: 96964
• Length: 704
• Species: Mus musculus
• Alignment Length: 723
• Identity: 140/723 - (19%)
• Similarity: 241/723 - (33%)
• Gaps: 246/723 - (34%)

  Fly  2728 YVLEGNVTLTDR--------------C--------DREYIVIFSGQ---SEVGRICRGMAMNS-- 2765
            ||||.::.:..:              |        :..||.:|.|.   |.||.|..|....|
Mouse    78 YVLEDSLEMNAKGVILNAFERYRLKTCIDFKPWSGEANYISVFKGSGCWSSVGNIHAGKQELSIG 142

  Fly  2766 TLLERPFSTI---------LYHSESRLAQQSKFILQAWKSVSSG-------------NAIRIDHR 2808
            |..:| .:|:         .:|.:|| |.:..:::..|..:..|             :::.:.:.
Mouse   143 TNCDR-IATVQHEFLHALGFWHEQSR-ADRDDYVIIVWDRIQPGKEHNFNIYNDSVSDSLNVPYD 205

  Fly  2809 PSPPVTISS---KNYLESK--QRIWEFVTNDGLSLRLHF-------LERIFIVSSPNCSTDRLTV 2861
            .:..:..|.   :|..||.  .||.||  .|.:..|:.|       |.:::     ||::....:
Mouse   206 YTSVMHYSKTAFQNGTESTIVTRISEF--EDVIGQRMDFSDYDLLKLNQLY-----NCTSSLSFM 263

  Fly  2862 ERYDQTTEEYIEVTSLCGRQAANDILVPSARMRVIFQTNSNITGDGFSFQVIPSCDSVLLAGAEI 2926
            :..|      .|:.::||       ::.|             :||...:|.:    |.:|:|.|
Mouse   264 DSCD------FELENICG-------MIQS-------------SGDSADWQRV----SQVLSGPE- 297

  Fly  2927 QTLASPSWAAFRGRQFNCSYT-FYAHDNHQVV---VSVRTRGR---PWASYACSRSYFEAYRRGD 2984
                     :...:...|..: |:.|.|..::   .:.....|   |...:.|...|.  |..|.
Mouse   298 ---------SDHSKMGQCKDSGFFMHFNTSILNEGATAMLESRLLYPKRGFQCLEFYL--YNSGS 351

  Fly  2985 GNGVGEESIGRLCPEFEVKGNGRV-----RLRYVSPLSRWFEMQYQLIQCGGNYSTSFT-LRPP- 3042
            ||    :.:.....|:.....|.|     :::.| |:..| ::.|..:|....:...|. ||.|
Mouse   352 GN----DQLNIYTREYTTGQQGGVLTLQRQIKEV-PIGSW-QLHYVTLQVTKKFRVVFEGLRGPG 410

  Fly  3043 -------------------------QN-------EDSSVYAHNTLCEWRITAPP-----QHAVVI 3070
                                     ||       :|:|||           :||     .:|..|
Mouse   411 TSSGGLSIDDINLSETRCPHHIWHIQNFTQILGGQDTSVY-----------SPPFYSSKGYAFQI 464

  Fly  3071 EFKYFDMESSRNCGFDSLTIYRGHVVSE------------EQRTGLLCGNVTNPETIIVNSNEAL 3123
               |.|:.||.|.|     || .|::|.            :|.|..|...  ||:......|:..
Mouse   465 ---YMDLRSSTNVG-----IY-FHLISGANDDQLQWPCPWQQATMTLLDQ--NPDIRQRMFNQRS 518

  Fly  3124 I----VLTTDSSNSYRGFLASVRFT---PNCNEH-----VALDLEVPRMSVMRQ--------YVV 3168
            |    .:|:|:.:.:....:.|..|   ||..:.     ....:.:.|..:..:        |::
Mouse   519 ITTDPTMTSDNGSYFWDRPSKVGVTDVFPNGTQFSRGIGYGTTVFITRERLKSREFIKGDDIYIL 583

  Fly  3169 NISESLLCIFQASAPPDYRISLEVRKLQLADDVVCRTCSYLEIHDS----KDVEGQNLGRYYGGT 3229
            ...|.:..:...||.||...:|.|.  ....:|||:......:.|.    |...|::.. |.|..
Mouse   584 LTVEDISHLNSTSAVPDPVPTLAVH--NACSEVVCQNGGICVVQDGRAECKCPAGEDWW-YMGKR 645

  Fly  3230 NGNEPSNRTKVFSSFSDMSFKLIATTGQAQKNISFELILQMVRTVCGQGEY--DLRLNETITLGM 3292
            .....|.|..|          :||.:..... .:..||:.:|...|.:.:|  ..|.|   |..|
Mouse   646 CEKRGSTRDTV----------IIAVSSTVTV-FAVMLIITLVSVYCTRRKYRKKARAN---TAAM 696

  Fly  3293 QYDNSTRF 3300
            ..:|...|
Mouse   697 TLENQHAF 704

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cubn2	NP_729748.3	cubilin_NTD	38..141	CDD:412063
		EGF_CA	156..190	CDD:238011
		EGF_CA	192..233	CDD:238011
		EGF_CA	290..328	CDD:214542
		EGF_CA	330..374	CDD:214542
		EGF	427..455	CDD:394967
		EGF_CA	462..496	CDD:238011
		CUB	503..619	CDD:238001
		CUB	624..738	CDD:238001
		CUB	745..854	CDD:238001
		CUB	857..963	CDD:238001
		CUB	1066..1179	CDD:238001
		CUB	1185..1293	CDD:238001
		CUB	1303..1406	CDD:238001
		CUB	1411..1523	CDD:238001
		CUB	1530..1648	CDD:238001
		CUB	1754..1862	CDD:238001
		CUB	1979..2091	CDD:238001
		CUB	2210..2321	CDD:238001
		CUB	2327..2441	CDD:238001
		CUB	2688..2782	CDD:412131	19/89 (21%)
		CUB	2810..2911	CDD:238001	21/112 (19%)
		CUB	3029..3143	CDD:238001	34/168 (20%)
		CUB	3169..3249	CDD:412131	18/83 (22%)
		CUB	3499..3607	CDD:238001
Mep1b	NP_032612.2	ZnMc	30..256	CDD:469599	36/186 (19%)
		MAM	266..429	CDD:459878	36/210 (17%)
		MATH	428..587	CDD:445786	35/180 (19%)
		EGF_CA	609..647	CDD:238011	8/38 (21%)