Protein Alignment Cubn2 and LOC1281762

DIOPT Version :10

• Sequence 1: NP_729748.3
• Gene: Cubn2 / 39334
• FlyBaseID: FBgn0259140
• Length: 3613
• Species: Drosophila melanogaster
• Sequence 2: XP_061508262.1
• Gene: LOC1281762 / 1281762
• VectorBaseID: AGAMI1_004783
• Length: 1402
• Species: Anopheles gambiae
• Alignment Length: 1235
• Identity: 249/1235 - (20%)
• Similarity: 398/1235 - (32%)
• Gaps: 401/1235 - (32%)

  Fly   631 TSTQTGVLRSPGYPGQARPELDCRWQLTA-----------PFGYRLLLR------------FYDI 672
            :|:.....||.| ..|..|....:|..:|           |..||...|            .:|
Mosquito   311 SSSSANEPRSGG-RAQPSPPAAAQWAASAAAAAPGCTASTPTPYRRGTRRKARPHEAAGTTLHD- 373

  Fly   673 SLGSSE--ASAGNCSQDSLIVYDSDRQLLRACQSIQPPPVYSSSNSL--------------RLDF 721
              |:||  ...|:.|..|        |....|:.    .||...||:              |...
Mosquito   374 --GNSERCMRGGDTSHGS--------QTSNTCRG----SVYHGDNSVSVIADKQQHYNEQRRQQQ 424

  Fly   722 HTDAIRSDSSFQMHYEVVPGHPGCGGVYTESRGRISGYMNFEVCLYLIEQPRGTQVKLVIDRVSL 786
            ....:|.:.....|.....|...|.||....|..:...                   |:::..:.
Mosquito   425 QQQQLRPEQQNHQHTRTAGGKRRCYGVRNALRMVLPAL-------------------LIVNMFTF 470

  Fly   787 VQSLSCHYLKIEIFDGRSTDAPLLRRICGS-HEESELEPIISIGNVILVRYEYALSGVRLSKSFD 850
            :..::            |.|..:.|.|..| :.::.       ..:.:|:|...||....:...|
Mosquito   471 LHGVA------------SDDVDVERHIAASAYTDTR-------SRISMVQYLEPLSRPTKAPKCD 516

  Fly   851 LTYTRVCTGNFNTNSGIISTPNYPGPYFDDMTCTY-NLTGPLDTAVRMRITDLSL------GTAN 908
            .|:.....|..|   |..|.|....|......|.| .|.|| ...|.:..|..||      |.|.
Mosquito   517 QTFVSRAGGPSN---GTFSAPMLSNPSNHSRQCLYIFLAGP-GQRVDVSFTSFSLRGTPPDGAAV 577

  Fly   909 NENDT---SYLDVYLSADQKRHIVKSTDNLILLSHSNRASLVFHGSGGGRGMRLEYNFVPNQCGG 970
            .|...   .|:|||..       |:|:|...|:          :...|||           .||
Mosquito   578 GELPACVHEYMDVYAE-------VQSSDPAELI----------NSPFGGR-----------YCG- 613

  Fly   971 FLNEPGRRYVTAVRGTFCQWFIDFPGRKKISIHTLGPTPSISIY--DNSTSPGKLVNSYSGSVGD 1033
                                  ..|.|::||::.   ..::|.|  .|||:|            |
Mosquito   614 ----------------------PIPPRRRISLYR---AIALSFYTDKNSTTP------------D 641

  Fly  1034 VFDGDLLTINLHTNWPRLEIYSIQFDIVQQ---DSCGGTFT---ARFGYIKSPNWPKNYGESQMC 1092
            :|:|....||           ..:::|.|.   ..|.....   .|.|.|.||.:|..|.:...|
Mosquito   642 IFEGRYAFIN-----------ETEYEIGQPVIGSPCSYVINFAQKRTGAIISPTYPGAYPKDMSC 695

  Fly  1093 EWILRAPFGHRIELVVHNFTLEEEYSSTGCWTDWLEIRNGDSESSPLIGRYCGNEIPSRIPSFGN 1157
            .:........|:.:...:|.|  .:....|..|::.:.:|...:|.:||.|||.:....:.|..:
Mosquito   696 TYQFIGKPSQRVRIEFRDFDL--FFGGPHCPFDYVRVFDGPDNTSAVIGTYCGQQRNLVLYSSEH 758

  Fly  1158 VLHLKFKSDDSMEEKGFLLSWQQMGAGCGGKLSSSMGTIHSPHLLAGNRGILACDWQIIVAEGSR 1222
            .|.:.|.:                       |..:..|        .|||...    |.....|.
Mosquito   759 YLFIHFST-----------------------LQRTANT--------QNRGFKG----IFEFSESF 788

  Fly  1223 VSLQ-LRSNDNRICSGQLTLYDGPTTASNPIVIRCNGTIAKPLQSTGNRVLVRYDVGHDAPDGTD 1286
            |.|. :|.||.....|.                .|:..|....:||
Mosquito   789 VKLDFIRENDGMHIRGS----------------ECDQKILSKKEST------------------- 818

  Fly  1287 FMLNYQTNCRVRLEGLQGAIETPNFPENYPPGQDCEWDIRAGGRKNHLQLIFSHLSV-------- 1343
                             |.:.:||:|..|.|...|.:.:.......:|:.:....|:
Mosquito   819 -----------------GFVYSPNYPFPYIPKVVCRYFVYGMQDAQNLERVKLEFSIFEIPKGEH 866

  Fly  1344 -EKFSSICLNDYVSLV----DMLDDQTLSEQHLCTNDGLEPITTVGNRLLLRFKSDSSVELQG-- 1401
             :|..|.|.:.|:.:.    ::.|.....:..||..:....:.:.|.||::.|   ||.||||
Mosquito   867 KDKSESNCTDGYLKVYLKGQEVADAYDKFDHELCGGELPHAVISDGPRLVMVF---SSGELQGRG 928

  Fly  1402 ------FRAEYKRIG-------CGEHLRESG---GRFESPNAP--FSVDMDCVWIITASEGNQIR 1448
                  |..|||..|       |....|.:.   |.|.||..|  :..:.:|.::..|:...|:.
Mosquito   929 FKAKYTFETEYKIPGTAAPDGTCSFTYRSTSRKKGEFNSPRYPSNYPSETNCSYVFLATPNEQVT 993

  Fly  1449 LLLHEVYFEAPQIECRDAESSLSVSAPSGYNSSVVLFRSCHEE-TQTQTFTSPGNELVI-RFVSS 1511
            ::     |:..:::...|.::     ...|.:||     |.|: .:.......|.:..: |:.|.
Mosquito   994 IV-----FDHFKVKADGANTT-----GGAYGASV-----CFEDWLEMYVLYRDGTDRFLGRYCSL 1043

  Fly  1512 SAPS----------------------RKYFKASFV-----QVPASCGGYISA-SSGVLTTPGFHN 1548
            :||.                      ...|||.::     .|...|||..|. .||::|:|.|..
Mosquito  1044 TAPGPVESPRGAVGIRVVLHTDLENVASGFKARYIFETAKSVFGDCGGNFSGEDSGIVTSPNFPA 1108

  Fly  1549 HQD--SKNVANYTSNIECVWTVEVTNGYGIRPHFEQFNLTD---SGNCSVSFVELTKLEPDNKEI 1608
            :.|  .|.:|:..    |.|.:....||.|..:|:.|.:..   :..|:.:.:.|. |.||:...
Mosquito  1109 NYDGPGKGLASRA----CNWYITARIGYKILLNFDYFAIEGEPATRGCAAAVMRLW-LSPDSDMP 1168

  Fly  1609 FLEKTCGEDSPMIR---IVHGRKLRVRFKS---QAGTWGRFIMYFERQCG--GRLSTGEGYLQSR 1665
            .:| .|||...|..   :..|:..|:.|.|   ..|..|..|::.|.|..  |..||.....:|.
Mosquito  1169 PIE-MCGEKPAMEHWQYVTQGQTARISFTSADKAIGAQGFRIIWTEVQDTPVGPSSTISLLCEST 1232

  Fly  1666 LDEECSWLVTSPEGSKLSLIINQLECPKCNAVSQNCSEGLQLLNDDDQV--LLYQMCRDHPANLI 1728
            ...:|   :||  |..:|      |..:|:.| :||..    |::.|::  ::.....||.|.:|
Mosquito  1233 YHFQC---LTS--GYCIS------ERLRCDGV-KNCGP----LDNSDEMHCIIIVPEEDHGALII 1281

  Fly  1729  1728
            Mosquito  1282  1281

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cubn2	NP_729748.3	cubilin_NTD	38..141	CDD:412063
		EGF_CA	156..190	CDD:238011
		EGF_CA	192..233	CDD:238011
		EGF_CA	290..328	CDD:214542
		EGF_CA	330..374	CDD:214542
		EGF	427..455	CDD:394967
		EGF_CA	462..496	CDD:238011
		CUB	503..619	CDD:238001
		CUB	624..738	CDD:238001	28/145 (19%)
		CUB	745..854	CDD:238001	16/109 (15%)
		CUB	857..963	CDD:238001	29/115 (25%)
		CUB	1066..1179	CDD:238001	24/115 (21%)
		CUB	1185..1293	CDD:238001	17/108 (16%)
		CUB	1303..1406	CDD:238001	27/123 (22%)
		CUB	1411..1523	CDD:238001	25/140 (18%)
		CUB	1530..1648	CDD:238001	36/129 (28%)
		CUB	1754..1862	CDD:238001
		CUB	1979..2091	CDD:238001
		CUB	2210..2321	CDD:238001
		CUB	2327..2441	CDD:238001
		CUB	2688..2782	CDD:412131
		CUB	2810..2911	CDD:238001
		CUB	3029..3143	CDD:238001
		CUB	3169..3249	CDD:412131
		CUB	3499..3607	CDD:238001
LOC1281762	XP_061508262.1	None