DRSC/TRiP Functional Genomics Resources

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Protein Alignment Cubn2 and Bmp1

DIOPT Version :10

Sequence 1:NP_729748.3 Gene:Cubn2 / 39334 FlyBaseID:FBgn0259140 Length:3613 Species:Drosophila melanogaster
Sequence 2:NP_033885.2 Gene:Bmp1 / 12153 MGIID:88176 Length:991 Species:Mus musculus


Alignment Length:832 Identity:200/832 - (24%)
Similarity:323/832 - (38%) Gaps:206/832 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly   961 YNFVPNQCGGFLNEPGRRYVTAVRGTFCQWFIDFPGRKKISIHTLG---------PTPS----IS 1012
            :.:.|..|..::...|........|..|..|       .|.:|.||         ..|.    :|
Mouse   183 FTYRPCGCCSYVGRRGGGPQAISIGKNCDKF-------GIVVHELGHVIGFWHEHTRPDRDRHVS 240

  Fly  1013 IYDNSTSPGKLVNSYS------GSVGDVFDGDLLT----------INLHTNWPRLEIYSIQFDIV 1061
            |...:..||:..|...      .|:|:.:|.|.:.          |.|.|..|:.|:..::..|.
Mouse   241 IVRENIQPGQEYNFLKMEVQEVESLGETYDFDSIMHYARNTFSRGIFLDTIVPKYEVNGVKPSIG 305

  Fly  1062 QQ-----------------DSCGGTFTARFGYIKSPNWPKNYGESQMCEWILRAPFGHRIELVVH 1109
            |:                 .:||.|.....|...||.:|..|.....|.|.:....|.:|.|   
Mouse   306 QRTRLSKGDIAQARKLYKCPACGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIIL--- 367

  Fly  1110 NFTLEEEYSSTGCWTDWLEIRNGDSESSPLIGRYCGNEIPSRIPSFGNVLHLKFKSDDSMEEKGF 1174
            |||..:.|.|..||.|::|:|:|....:||.||:||.::|..|.|..:.|.::|:|..:...|||
Mouse   368 NFTSMDLYRSRLCWYDYVEVRDGFWRKAPLRGRFCGGKLPEPIVSTDSRLWVEFRSSSNWVGKGF 432

  Fly  1175 LLSWQQMGAGCGGKLSSSMGTIHSPHLLAGNRGILACDWQIIVAEGSRVSLQLRS-----NDNRI 1234
            ...::   |.|||.:....|.|.||:.....|....|.|:|.|:||..|.|..:|     :|:  
Mouse   433 FAVYE---AICGGDVKKDNGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDS-- 492

  Fly  1235 CS-GQLTLYDGPTTASNPIVIRCNGTIAKPLQSTGNRVLVRY----------------------- 1275
            |: ..|.:.||.:.:||.|...|.......::||.:|:.:::                       
Mouse   493 CAYDYLEVRDGHSESSNLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDECS 557

  Fly  1276 ----------------------DVGHD-APDGTDFMLNYQTNCRVRLEG----LQGAIETPNFPE 1313
                                  |.|:: |||        :..|.....|    |.|:|.:|.:|:
Mouse   558 RPNRGGCEQRCLNTLGSYKCSCDPGYELAPD--------KRRCEAACGGFLTKLNGSITSPGWPK 614

  Fly  1314 NYPPGQDCEWDIRAGGRKNHLQLIFSHLSVEKFSSICLNDYVSLVDMLDDQTLSEQHLCTNDGLE 1378
            .|||.::|.|.:.| ..:..:.|.|.....|. :.:|..|:|.:...|...:......|.::..|
Mouse   615 EYPPNKNCIWQLVA-PTQYRISLQFDFFETEG-NDVCKYDFVEVRSGLTADSKLHGKFCGSEKPE 677

  Fly  1379 PITTVGNRLLLRFKSDSSVELQGFRAEY------------------------------------- 1406
            .||:..|.:.:.||||::|..:||:|.:                                     
Mouse   678 VITSQYNNMRVEFKSDNTVSKKGFKAHFFSDKDECSKDNGGCQQDCVNTFGSYECQCRSGFVLHD 742

  Fly  1407 -----KRIGCGEHLRESGGRFESPNAP--FSVDMDCVWIITASEGNQIRLLLHEVYFEAPQIEC- 1463
                 |..||...:..:.|...|||.|  :....:|.|.|:::.|::::|...|:..|: |.|| 
Mouse   743 NKHDCKEAGCEHKVTSTSGTITSPNWPDKYPSKKECTWAISSTPGHRVKLTFVEMDIES-QPECA 806

  Fly  1464 ---------RDAESSLSVSAPSGYNSSVVLFRSCHEETQTQTFTSPGNELVIRFVSSSAPSRKYF 1519
                     |||:      ||       ||.|.|..: :.:...:.||.:.:||.|.::..||.|
Mouse   807 YDHLEVFDGRDAK------AP-------VLGRFCGSK-KPEPVLATGNRMFLRFYSDNSVQRKGF 857

  Fly  1520 KASFVQVPASCGGYISASSGVLTTPGFHNH-QDSKNVANYTSNIECVWTVEVTNGYGIRPHFEQF 1583
            :||.   ...|||.:.|.   :.|...::| |...|  ||...::|.|.:....|||:...|:.|
Mouse   858 QASH---STECGGQVRAD---VKTKDLYSHAQFGDN--NYPGGVDCEWVIVAEEGYGVELVFQTF 914

  Fly  1584 NLTDSGNCSVSFVELTKLEPDNKEIFLEKTCGEDSPMIRIVHGRKLRVRFKS 1635
            .:.:..:|...::||.. ..|:....|.:.||...|......|..:.|:|.|
Mouse   915 EVEEETDCGYDYIELFD-GYDSTAPRLGRYCGSGPPEEVYSAGDSVLVKFHS 965

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Cubn2NP_729748.3 cubilin_NTD 38..141 CDD:412063
EGF_CA 156..190 CDD:238011
EGF_CA 192..233 CDD:238011
EGF_CA 290..328 CDD:214542
EGF_CA 330..374 CDD:214542
EGF 427..455 CDD:394967
EGF_CA 462..496 CDD:238011
CUB 503..619 CDD:238001
CUB 624..738 CDD:238001
CUB 745..854 CDD:238001
CUB 857..963 CDD:238001 0/1 (0%)
CUB 1066..1179 CDD:238001 39/112 (35%)
CUB 1185..1293 CDD:238001 34/159 (21%)
CUB 1303..1406 CDD:238001 30/102 (29%)
CUB 1411..1523 CDD:238001 34/123 (28%)
CUB 1530..1648 CDD:238001 29/107 (27%)
CUB 1754..1862 CDD:238001
CUB 1979..2091 CDD:238001
CUB 2210..2321 CDD:238001
CUB 2327..2441 CDD:238001
CUB 2688..2782 CDD:412131
CUB 2810..2911 CDD:238001
CUB 3029..3143 CDD:238001
CUB 3169..3249 CDD:412131
CUB 3499..3607 CDD:238001
Bmp1NP_033885.2 ZnMc_BMP1_TLD 126..325 CDD:239808 27/148 (18%)
CUB 327..436 CDD:395345 39/111 (35%)
CUB 440..549 CDD:395345 29/110 (26%)
FXa_inhibition 560..592 CDD:464251 5/39 (13%)
CUB 596..705 CDD:395345 32/110 (29%)
FXa_inhibition 712..747 CDD:464251 0/34 (0%)
CUB 752..861 CDD:395345 34/123 (28%)
CUB 865..978 CDD:395345 29/107 (27%)
Blue background indicates that the domain is not in the aligned region.

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