DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Cubn2 and Ltbp4

DIOPT Version :10

Sequence 1:NP_729748.3 Gene:Cubn2 / 39334 FlyBaseID:FBgn0259140 Length:3613 Species:Drosophila melanogaster
Sequence 2:NP_783572.2 Gene:Ltbp4 / 108075 MGIID:1321395 Length:1666 Species:Mus musculus


Alignment Length:944 Identity:224/944 - (23%)
Similarity:296/944 - (31%) Gaps:328/944 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly   138 RVERVKGILQTLAGN-----------LARNEC--LSNPCKNGGTCHDAYKGFQCECPAGWQ---- 185
            |.|...|..:.:.|.           |..:||  :..|| :.|.|.:....|.|.||||:|    
Mouse   645 RCENTPGSFRCVCGTGFQAGPRATECLDVDECRRVPPPC-DRGRCENTPGSFLCVCPAGYQAAPH 708

  Fly   186 GDSCEDDVNECFTLAGTDLDGCLNNGQCINTPGSYRCVCRNGFTGTHCRLRHNTCLFGGSRELCG 250
            |.||: ||:||     |...|....|.|.|.|||:||||..||.|:.|....:.|  ......||
Mouse   709 GASCQ-DVDEC-----TQSPGLCGRGVCENLPGSFRCVCPAGFRGSACEEDVDEC--AQQPPPCG 765

  Fly   251 EHGTCIQAANSAGYVCICDQGW-------TWADANVTSASPSACV-------------------- 288
            . |.|...|.|  :.|.|..|:       ...|.:..|.|||.|.                    
Mouse   766 P-GRCDNTAGS--FHCACPAGFRSRGPGAPCQDVDECSRSPSPCAYGRCENTEGSFKCVCPTGFQ 827

  Fly   289 --------RDVDECEPRVNPCHDECINLPGSFRCGACPTGYTGDGRFCRDIDECASEDNGGCSLQ 345
                    .||||||.|:.....||:|.||||:|.|||.|:......|.|:|||:|  ...|.|.
Mouse   828 PNAAGSECEDVDECENRLACPGQECVNSPGSFQCRACPVGHHLHRGRCTDVDECSS--GTPCGLH 890

  Fly   346 PRVTCTNTEGSHRCGRCPAGWTG-DGRTCTASDSNSCNNEGICHPLAKCEYVSDMVVCTCPLGSF 409
            .:  ||||:||..|. |..|:.. .|:....:|.|.|.....|.|..:|........|||..|..
Mouse   891 GQ--CTNTKGSFHCS-CSTGYRAPSGQPGPCADINECLEGDFCFPHGECLNTDGSFTCTCAPGYR 952

  Fly   410 GHGYGADGCSADSSRLPCDQHPCQNNGTCVQNGRGTTCICQPGYSG----VVCNSSDACHP-SPC 469
            ....||.....|.    |.:.....:|.|........|||.||:..    ..|...|.|.. .|.
Mouse   953 PGPRGASCLDVDE----CSEEDLCQSGICTNTDGSFECICPPGHRAGPDLASCLDIDECRERGPA 1013

  Fly   470 LNGG-TCRLLPDAKYQCV--CPRGY----TGT-------------TCSHQR-------FFCGVTI 507
            |.|. .|...| ..|:||  |..||    .||             .|..||       :.|    
Mouse  1014 LCGSQRCENSP-GSYRCVRDCDPGYHPGPEGTCDDIDECREYGSAICGAQRCENTPGSYRC---- 1073

  Fly   508 RGPSGQLHYPPNTADGDYQADERCPFIIRTNRN------MVLNLTFTQFQ---------LEDSAD 557
             .|:....|.|....|....|| |     .||:      |..||. ..||         ..|...
Mouse  1074 -TPACDPGYQPTPGGGCQDVDE-C-----RNRSFCGAHAMCQNLP-GSFQCVCDQGYEGARDGRH 1130

  Fly   558 CT----ADFLQLHDGNSLSSRLIGRF-----------------C-----------GSR------- 583
            |.    .:.||...|::|...:.|.|                 |           ||:       
Mouse  1131 CVDVNECETLQGVCGSALCENVEGSFLCVCPNSPEEFDPMTGRCVPPRAPAGTFPGSQPQAPASP 1195

  Fly   584 ---------------LPMTNGSVITTQEQVFFWFRSDNQTQGKGFHVIWNSLPFSCGETI--NLT 631
                           .|...|.|.:.:.:.:|    |            .:.|.:|...:  |:|
Mouse  1196 SLPARPPAPPPPRRPSPPRQGPVSSGRRECYF----D------------TAAPDACDNILARNVT 1244

  Fly   632 STQTGVLRSPGY---------PGQARPELDCRWQLTAPFGYRLLLRFYDISLGSSEASAGNCS-- 685
            ..:.......|:         ||....|    :|...|.|...|:...|:   |:......|.  
Mouse  1245 WQECCCTVGEGWGSGCRIQQCPGTETAE----YQSLCPHGRGYLVPSGDL---SARRDVDECQLF 1302

  Fly   686 QDSLIVYDSDRQLLRACQS---IQPPPVYSSSNSLRLDFHT---DAIRSDSSFQMHYEVVPGHPG 744
            ||            :.|:|   :...|.||...|....:|.   :.:.:|       |.....|.
Mouse  1303 QD------------QVCKSGVCVNTAPGYSCYCSNGFYYHAHRLECVDND-------ECADEEPA 1348

  Fly   745 CGGVYTESRGRISGYMNFEVCLYLIEQPRGTQVKLVIDRVSLVQSLSCHYLKIEIFDGRSTDAPL 809
            |.|      ||         |                  |:.|.|..|......:.||.      
Mouse  1349 CEG------GR---------C------------------VNTVGSYHCTCEPPLVLDGS------ 1374

  Fly   810 LRRICGSHEESELEPII-----SIGNVILVRYEYALSGVRLSKSFDLTYTRVC------------ 857
             ||.|.|:|...|:..:     .:|.      :...|..||.:  ..|||..|            
Mouse  1375 -RRRCVSNESQSLDDNLGVCWQEVGP------DLVCSRPRLDR--QATYTECCCLYGEAWGMDCA 1430

  Fly   858 ------TGNFNTNSGIISTPNY----PG----PY 877
                  :.:|.....::..|.|    ||    ||
Mouse  1431 LCPAQDSDDFEALCNVLRPPAYGPPRPGGFGIPY 1464

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Cubn2NP_729748.3 cubilin_NTD 38..141 CDD:412063 1/2 (50%)
EGF_CA 156..190 CDD:238011 15/39 (38%)
EGF_CA 192..233 CDD:238011 19/40 (48%)
EGF_CA 290..328 CDD:214542 19/37 (51%)
EGF_CA 330..374 CDD:214542 17/44 (39%)
EGF 427..455 CDD:394967 8/27 (30%)
EGF_CA 462..496 CDD:238011 15/54 (28%)
CUB 503..619 CDD:238001 31/184 (17%)
CUB 624..738 CDD:238001 24/132 (18%)
CUB 745..854 CDD:238001 22/113 (19%)
CUB 857..963 CDD:238001 8/47 (17%)
CUB 1066..1179 CDD:238001
CUB 1185..1293 CDD:238001
CUB 1303..1406 CDD:238001
CUB 1411..1523 CDD:238001
CUB 1530..1648 CDD:238001
CUB 1754..1862 CDD:238001
CUB 1979..2091 CDD:238001
CUB 2210..2321 CDD:238001
CUB 2327..2441 CDD:238001
CUB 2688..2782 CDD:412131
CUB 2810..2911 CDD:238001
CUB 3029..3143 CDD:238001
CUB 3169..3249 CDD:412131
CUB 3499..3607 CDD:238001
Ltbp4NP_783572.2 EGF_CA 356..>386 CDD:214542
TB 417..458 CDD:459903
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 473..590
cEGF 612..633 CDD:463661
EGF_CA 630..666 CDD:214542 4/20 (20%)
EGF_CA 672..713 CDD:214542 15/41 (37%)
EGF_CA 714..751 CDD:238011 19/41 (46%)
EGF_CA 753..787 CDD:238011 10/38 (26%)
EGF_CA 795..836 CDD:214542 6/40 (15%)
EGF_CA 877..909 CDD:238011 16/36 (44%)
EGF_CA 920..956 CDD:214542 10/35 (29%)
EGF_CA 962..997 CDD:214542 9/38 (24%)
EGF_CA 1003..1041 CDD:214542 13/38 (34%)
EGF_CA 1091..1132 CDD:214542 11/47 (23%)
EGF_CA 1133..1161 CDD:473889 6/27 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1171..1221 6/49 (12%)
TB 1235..1277 CDD:459903 8/45 (18%)
EGF_CA 1338..>1367 CDD:238011 12/68 (18%)
TB 1402..1444 CDD:459903 8/43 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1488..1566
EGF_CA 1616..>1650 CDD:214542
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.