Protein Alignment Gcat and SPTLC2

DIOPT Version :10

• Sequence 1: NP_648509.1
• Gene: Gcat / 39333
• FlyBaseID: FBgn0036208
• Length: 417
• Species: Drosophila melanogaster
• Sequence 2: NP_004854.1
• Gene: SPTLC2 / 9517
• HGNCID: 11278
• Length: 562
• Species: Homo sapiens
• Alignment Length: 373
• Identity: 133/373 - (35%)
• Similarity: 202/373 - (54%)
• Gaps: 24/373 - (6%)

  Fly    64 KKILNFCANNYLGLANNP-EIVEHSQKLLEQYGAGLSSVRFICGTQDIHKQLEKKIAQFHGREDT 127
            |.::|..:.||||.|.|. ...|.:.|:||:||||:.|.|...|..|.|::||:.:|:|.|.|..
Human   168 KGVINMGSYNYLGFARNTGSCQEAAAKVLEEYGAGVCSTRQEIGNLDKHEELEELVARFLGVEAA 232

  Fly   128 ILYASCFDANAGIFEAILTPEDAVFSDELNHASIIDGIRLCKAKKQRYRHRDLGDLEEQLKASDA 192
            :.|...|..|:....|::.....:.||||||||::.|.||..|..:.::|.::..||:.||  ||
Human   233 MAYGMGFATNSMNIPALVGKGCLILSDELNHASLVLGARLSGATIRIFKHNNMQSLEKLLK--DA 295

  Fly   193 ------------RLKLIATDGVFSMDGNIAPLARIVELARKYNALVFVDECHATGFFGATGRGTE 245
                        :..||..:|::||:|:|..|..::.|.:||.|.:::||.|:.|..|.||||..
Human   296 IVYGQPRTRRPWKKILILVEGIYSMEGSIVRLPEVIALKKKYKAYLYLDEAHSIGALGPTGRGVV 360

  Fly   246 EYDNVMGE-VDIINSTLGKALGGASGGYTTGPAELISFLRQKSRPYLFSNTLPPAVVAVGLKVMD 309
            ||..:..| ||::..|..|:. ||||||..|..|||.:||..|...:::.:|.|.||...:..|.
Human   361 EYFGLDPEDVDVMMGTFTKSF-GASGGYIGGKKELIDYLRTHSHSAVYATSLSPPVVEQIITSMK 424

  Fly   310 MLL------QSSELTQRVQSNTQRFRQAMTKAGFTIAG-ENHPICPVMLGDARLASQFADEMLTR 367
            .::      ...|..|::..||:.||:.:.:.||.|.| |:.|:.|:||........|..|||.|
Human   425 CIMGQDGTSLGKECVQQLAENTRYFRRRLKEMGFIIYGNEDSPVVPLMLYMPAKIGAFGREMLKR 489

  Fly   368 GIYVIGFSYPVVPQGKARIRVQISAAHTEAEIDRAINAFIEVGRSLKV 415
            .|.|:...:|..|..::|.|..:|||||:..:|.|:....|||..|::
Human   490 NIGVVVVGFPATPIIESRARFCLSAAHTKEILDTALKEIDEVGDLLQL 537

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gcat	NP_648509.1	PRK06939	19..416	CDD:235893	133/373 (36%)
SPTLC2	NP_004854.1	AAT_I	67..542	CDD:450240	133/373 (36%)