DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10361 and alas1

DIOPT Version :9

Sequence 1:	NP_648509.1	Gene:	CG10361 / 39333	FlyBaseID:	FBgn0036208	Length:	417	Species:	Drosophila melanogaster
Sequence 2:	NP_958444.1	Gene:	alas1 / 64608	ZFINID:	ZDB-GENE-001229-2	Length:	613	Species:	Danio rerio

Alignment Length:	395	Identity:	131/395 - (33%)
Similarity:	217/395 - (54%)	Gaps:	21/395 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 KDAGTFKAERIITSSQSTQITVQGSDKKILNF-------CANNYLGLANNPEIVEHSQKLLEQYG 95
            |...|::..:.: :.::|:..:.....:.|:|       |:|:|||::.:|.:|:.....|.::|
Zfish   184 KSDHTYRVFKTV-NRRATEFPMADDYTESLSFKRNVSVWCSNDYLGMSRHPRVVQTIMDTLGKHG 247

  Fly    96 AGLSSVRFICGTQDIHKQLEKKIAQFHGREDTILYASCFDAN-AGIFE-AILTPEDAVFSDELNH 158
            :|....|.|.||...|..||.::|..||::..:|:.|||.|| :.:|. |.:.|...::||..||
Zfish   248 SGAGGTRNISGTSKFHVDLEHELADLHGKDAALLFTSCFVANDSTLFTLAKMMPGCEIYSDAGNH 312

  Fly   159 ASIIDGIRLCKAKKQRYRHRDLGDLEEQLKASD-ARLKLIATDGVFSMDGNIAPLARIVELARKY 222
            ||:|.|||...|||..:||.|...|.|.|:.|| :..|::|.:.|.||||.:.||.::.::|.::
Zfish   313 ASMIQGIRNSGAKKFIFRHNDAKHLRELLEKSDPSTPKIVAFETVHSMDGAVCPLEQLCDVAHEF 377

  Fly   223 NALVFVDECHATGFFGATGRGTEEYDNVMGEVDIINSTLGKALGGASGGYTTGPAELISFLRQKS 287
            .|:.||||.||.|.:|..|.|..:.|:||.::|||:.|||||. |..|||......|:..:|..:
Zfish   378 GAVTFVDEVHAVGLYGPRGGGIGDRDSVMHKMDIISGTLGKAF-GCVGGYIASTHALVDTVRSYA 441

  Fly   288 RPYLFSNTLPPAVVAVGLKVMDMLLQSSE---LTQRVQSNTQRFRQAMTKAGFTIAGENHPICPV 349
            ..::|:.:|||.::: |.:....:|:|.|   |.::.|.|....||.:..:|..:......|.||
Zfish   442 AGFIFTTSLPPMLLS-GARQSVQILKSEEGRTLRRKHQRNVTLLRQMLMDSGLPVIHCPSHIIPV 505

  Fly   350 MLGDARLASQFADEMLTR-GIYVIGFSYPVVPQGKARIRVQISAAHT----EAEIDRAINAFIEV 409
            .:.||...::..|.|::| .|||...:||.|.:|:..:|:..:..||    :..:|:....:.||
Zfish   506 RVADAEKNTEVCDIMMSRYNIYVQAINYPTVARGEELLRIAPTPHHTPQMMKYFVDKLTQTWTEV 570

  Fly   410 GRSLK 414
            |..||
Zfish   571 GLPLK 575

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10361	NP_648509.1	PRK06939	19..416	CDD:235893	131/395 (33%)
CG10361	NP_648509.1	BioF	30..410	CDD:223234	127/389 (33%)
alas1	NP_958444.1	Preseq_ALAS	4..120	CDD:286162
		AAT_I	170..575	CDD:302748	129/393 (33%)
		BioF	170..567	CDD:223234	126/385 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0156
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG58214
OrthoDB	1	1.010	-	-		D930001at2759
OrthoFinder	1	1.000	-	-		FOG0000902
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100359
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R554
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.760