Protein Alignment Gcat and SPTLC3

DIOPT Version :10

• Sequence 1: NP_648509.1
• Gene: Gcat / 39333
• FlyBaseID: FBgn0036208
• Length: 417
• Species: Drosophila melanogaster
• Sequence 2: NP_060797.2
• Gene: SPTLC3 / 55304
• HGNCID: 16253
• Length: 552
• Species: Homo sapiens
• Alignment Length: 375
• Identity: 127/375 - (33%)
• Similarity: 204/375 - (54%)
• Gaps: 28/375 - (7%)

  Fly    64 KKILNFCANNYLGL-ANNPEIVEHSQKLLEQYGAGLSSVRFICGTQDIHKQLEKKIAQFHGREDT 127
            |.::|..:.|:||| |...|.:...:.:||.||.|::|.|...||.|.||:||..:|:|...|..
Human   160 KDVINMGSYNFLGLAAKYDESMRTIKDVLEVYGTGVASTRHEMGTLDKHKELEDLVAKFLNVEAA 224

  Fly   128 ILYASCFDANAGIFEAILTPEDAVFSDELNHASIIDGIRLCKAKKQRYRHRDLGDLEEQLKASDA 192
            :::...|..|:....|::.....:.||||||.|::.|.||..|..:.::|.:...||:.|:  ||
Human   225 MVFGMGFATNSMNIPALVGKGCLILSDELNHTSLVLGARLSGATIRIFKHNNTQSLEKLLR--DA 287

  Fly   193 ------------RLKLIATDGVFSMDGNIAPLARIVELARKYNALVFVDECHATGFFGATGRGTE 245
                        :..||..:||:||:|:|..|.:|:.|.:||.|.:::||.|:.|..|.||||..
Human   288 VIYGQPRTRRAWKKILILVEGVYSMEGSIVHLPQIIALKKKYKAYLYIDEAHSIGAVGPTGRGVT 352

  Fly   246 EYDNV-MGEVDIINSTLGKALGGASGGYTTGPAELISFLRQKSRPYLFSNTLPPAV---VAVGLK 306
            |:..: ..|||::..|..|:. ||||||..|..:|:.:||..|...::::::.|.:   :...||
Human   353 EFFGLDPHEVDVLMGTFTKSF-GASGGYIAGRKDLVDYLRVHSHSAVYASSMSPPIAEQIIRSLK 416

  Fly   307 V---MDMLLQSSELTQRVQSNTQRFRQAMTKAGFTIAG-ENHPICPVMLGDARLASQFADEMLTR 367
            :   :|...|..:..|::..||:.|||.:.:.||.|.| ||..:.|::|......:.||..||.:
Human   417 LIMGLDGTTQGLQRVQQLAKNTRYFRQRLQEMGFIIYGNENASVVPLLLYMPGKVAAFARHMLEK 481

  Fly   368 --GIYVIGFSYPVVPQGKARIRVQISAAHTEAEIDRAINAFIEVGRSLKV 415
              |:.|:||  |..|..:||.|..:|||||...:|..:.|..|:|..|::
Human   482 KIGVVVVGF--PATPLAEARARFCVSAAHTREMLDTVLEALDEMGDLLQL 529

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gcat	NP_648509.1	PRK06939	19..416	CDD:235893	127/375 (34%)
SPTLC3	NP_060797.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..29
		AAT_I	57..549	CDD:450240	127/375 (34%)