Protein Alignment Gcat and ALAS2

DIOPT Version :10

• Sequence 1: NP_648509.1
• Gene: Gcat / 39333
• FlyBaseID: FBgn0036208
• Length: 417
• Species: Drosophila melanogaster
• Sequence 2: NP_000023.2
• Gene: ALAS2 / 212
• HGNCID: 397
• Length: 587
• Species: Homo sapiens
• Alignment Length: 363
• Identity: 126/363 - (34%)
• Similarity: 217/363 - (59%)
• Gaps: 11/363 - (3%)

  Fly    62 SDKKILNFCANNYLGLANNPEIVEHSQKLLEQYGAGLSSVRFICGTQDIHKQLEKKIAQFHGRED 126
            :.|.:..:|:|:|||::.:|::::.:|:.|:::|||....|.|.||...|.:||:::|:.|.::.
Human   187 ASKDVSVWCSNDYLGMSRHPQVLQATQETLQRHGAGAGGTRNISGTSKFHVELEQELAELHQKDS 251

  Fly   127 TILYASCFDAN-AGIFE-AILTPEDAVFSDELNHASIIDGIRLCKAKKQRYRHRDLGDLEEQLKA 189
            .:|::|||.|| :.:|. |.:.|...::||..||||:|.|||...|.|..:||.|...|::.|:.
Human   252 ALLFSSCFVANDSTLFTLAKILPGCEIYSDAGNHASMIQGIRNSGAAKFVFRHNDPDHLKKLLEK 316

  Fly   190 SDARL-KLIATDGVFSMDGNIAPLARIVELARKYNALVFVDECHATGFFGATGRGTEEYDNVMGE 253
            |:.:: |::|.:.|.||||.|.||..:.:::.:|.||.||||.||.|.:|:.|.|..|.|.:|.:
Human   317 SNPKIPKIVAFETVHSMDGAICPLEELCDVSHQYGALTFVDEVHAVGLYGSRGAGIGERDGIMHK 381

  Fly   254 VDIINSTLGKALGGASGGYTTGPAELISFLRQKSRPYLFSNTLPPAVVAVGLKVMDMLL--QSSE 316
            :|||:.|||||. |..|||.....:|:..:|..:..::|:.:|||.|::..|:.:.:|.  :...
Human   382 IDIISGTLGKAF-GCVGGYIASTRDLVDMVRSYAAGFIFTTSLPPMVLSGALESVRLLKGEEGQA 445

  Fly   317 LTQRVQSNTQRFRQAMTKAGFTIAGENHPICPVMLGDARLASQFADEMLTR-GIYVIGFSYPVVP 380
            |.:..|.|.:..||.:...|..:......|.|:.:|:|.|.|:..|.:|:: ||||...:||.||
Human   446 LRRAHQRNVKHMRQLLMDRGLPVIPCPSHIIPIRVGNAALNSKLCDLLLSKHGIYVQAINYPTVP 510

  Fly   381 QGKARIRVQISAAHT----EAEIDRAINAFIEVGRSLK 414
            :|:..:|:..|..|:    |..:::.:.|:..||..|:
Human   511 RGEELLRLAPSPHHSPQMMEDFVEKLLLAWTAVGLPLQ 548

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gcat	NP_648509.1	PRK06939	19..416	CDD:235893	126/363 (35%)
ALAS2	NP_000023.2	Preseq_ALAS	5..100	CDD:462658
		5aminolev_synth	143..548	CDD:273820	125/361 (35%)