DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10361 and ALAS1

DIOPT Version :9

Sequence 1:	NP_648509.1	Gene:	CG10361 / 39333	FlyBaseID:	FBgn0036208	Length:	417	Species:	Drosophila melanogaster
Sequence 2:	NP_001291373.1	Gene:	ALAS1 / 211	HGNCID:	396	Length:	657	Species:	Homo sapiens

Alignment Length:	417	Identity:	139/417 - (33%)
Similarity:	222/417 - (53%)	Gaps:	46/417 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 KDAGTFKAERII-----------------TSSQSTQITVQGSD--------KKILNFCANNYLGL 77
            |...||:.:|..                 |.::...|.....|        |::..:|:|:|||:
Human   209 KSVSTFQYDRFFEKKIDEKKNDHTYRVFKTVNRRAHIFPMADDYSDSLITKKQVSVWCSNDYLGM 273

  Fly    78 ANNPEIVEHSQKLLEQYGAGLSSVRFICGTQDIHKQLEKKIAQFHGREDTILYASCFDAN-AGIF 141
            :.:|.:.......|:|:|||....|.|.||...|..||:::|..||::..:|::|||.|| :.:|
Human   274 SRHPRVCGAVMDTLKQHGAGAGGTRNISGTSKFHVDLERELADLHGKDAALLFSSCFVANDSTLF 338

  Fly   142 E-AILTPEDAVFSDELNHASIIDGIRLCKAKKQRYRHRDLGDLEEQLKASDARL-KLIATDGVFS 204
            . |.:.|...::||..||||:|.|||..:..|..:||.|:..|.|.|:.||..: |::|.:.|.|
Human   339 TLAKMMPGCEIYSDSGNHASMIQGIRNSRVPKYIFRHNDVSHLRELLQRSDPSVPKIVAFETVHS 403

  Fly   205 MDGNIAPLARIVELARKYNALVFVDECHATGFFGATGRGTEEYDNVMGEVDIINSTLGKALGGAS 269
            |||.:.||..:.::|.::.|:.||||.||.|.:||.|.|..:.|.||.::|||:.|||||. |..
Human   404 MDGAVCPLEELCDVAHEFGAITFVDEVHAVGLYGARGGGIGDRDGVMPKMDIISGTLGKAF-GCV 467

  Fly   270 GGYTTGPAELISFLRQKSRPYLFSNTLPPAVVAVGLKVMDMLLQSSE---LTQRVQSNTQRFRQA 331
            |||....:.||..:|..:..::|:.:|||.::|..|:.: .:|:|:|   |.::.|.|.:..||.
Human   468 GGYIASTSSLIDTVRSYAAGFIFTTSLPPMLLAGALESV-RILKSAEGRVLRRQHQRNVKLMRQM 531

  Fly   332 MTKAGFTIAGENHPICPVMLGDARLASQFADEMLTR-GIYVIGFSYPVVPQGKARIRVQISAAHT 395
            :..||..:......|.||.:.||...::..||:::| .|||...:||.||:|:..:|:..:..||
Human   532 LMDAGLPVVHCPSHIIPVRVADAAKNTEVCDELMSRHNIYVQAINYPTVPRGEELLRIAPTPHHT 596

  Fly   396 EAEIDRAINAFIE--------VGRSLK 414
                .:.:|.|:|        ||..||
Human   597 ----PQMMNYFLENLLVTWKQVGLELK 619

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10361	NP_648509.1	PRK06939	19..416	CDD:235893	139/417 (33%)
CG10361	NP_648509.1	BioF	30..410	CDD:223234	135/411 (33%)
ALAS1	NP_001291373.1	Preseq_ALAS	19..154	CDD:286162
		AAT_I	214..619	CDD:302748	135/410 (33%)
		BioF	214..605	CDD:223234	132/396 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG58214
OrthoDB	1	1.010	-	-		D930001at2759
OrthoFinder	1	1.000	-	-		FOG0000902
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100359
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R554
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.860