Protein Alignment Gcat and SPTLC1

DIOPT Version :10

• Sequence 1: NP_648509.1
• Gene: Gcat / 39333
• FlyBaseID: FBgn0036208
• Length: 417
• Species: Drosophila melanogaster
• Sequence 2: NP_001268232.1
• Gene: SPTLC1 / 10558
• HGNCID: 11277
• Length: 513
• Species: Homo sapiens
• Alignment Length: 344
• Identity: 96/344 - (27%)
• Similarity: 171/344 - (49%)
• Gaps: 25/344 - (7%)

  Fly    48 IITSSQSTQITVQGSDKKILNFCANNYLGLANNPEIVEHSQKLLEQYGAGLSSVRFICGTQDIHK 112
            |::...|.:..|.|  |:.:||.:.|:|||.:||.:...:...|::||.|....|...||.|:|.
Human    84 IVSGPPSHKTVVNG--KECINFASFNFLGLLDNPRVKAAALASLKKYGVGTCGPRGFYGTFDVHL 146

  Fly   113 QLEKKIAQFHGREDTILYASCFDANAGIFEAILTPEDAVFSDELNHASIIDGIRLCKAKKQRYRH 177
            .||.::|:|...|:.|:|:..|...|....|.....|.||.|.....:|..|::..::..:.::|
Human   147 DLEDRLAKFMKTEEAIIYSYGFATIASAIPAYSKRGDIVFVDRAACFAIQKGLQASRSDIKLFKH 211

  Fly   178 RDLGDLEEQLKASD---------ARL--KLIATDGVFSMDGNIAPLARIVELARKYNALVFVDEC 231
            .|:.|||..||..:         ||:  :.|..:|::...|.|.||..:|:|..||.|.:|::|.
Human   212 NDMADLERLLKEQEIEDQKNPRKARVTRRFIVVEGLYMNTGTICPLPELVKLKYKYKARIFLEES 276

  Fly   232 HATGFFGATGRG-TEEYDNVMGEVDIINSTLGKALGGASGGYTTGPAELISFLRQKSRPYLFSNT 295
            .:.|..|..||| ||.|...:.::|:|::.:..|| .:.||:..|.:.:|...|...:.|.||.:
Human   277 LSFGVLGEHGRGVTEHYGINIDDIDLISANMENAL-ASIGGFCCGRSFVIDHQRLSGQGYCFSAS 340

  Fly   296 LPPAVVAVGLKVMDMLLQSSELTQRVQSNTQRFRQAMTK-AGFTIAGEN-HPICPVML------- 351
            |||.:.|..::.::::.::..:...::....:..:|:.. :|..:.||: .|...:.|
Human   341 LPPLLAAAAIEALNIMEENPGIFAVLKEKCGQIHKALQGISGLKVVGESLSPAFHLQLEESTGSR 405

  Fly   352 -GDARLASQFADEMLTRGI 369
             .|.||..:..|:.:.|.|
Human   406 EQDVRLLQEIVDQCMNRSI 424

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gcat	NP_648509.1	PRK06939	19..416	CDD:235893	96/344 (28%)
SPTLC1	NP_001268232.1	Interaction with SPTLC2. /evidence=ECO:0000269|PubMed:33558762	1..66
		AAT_I	11..442	CDD:450240	96/344 (28%)