DRSC/TRiP Functional Genomics Resources

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Protein Alignment Klp68D and KIF3B

DIOPT Version :9

Sequence 1:NP_001261726.1 Gene:Klp68D / 39332 FlyBaseID:FBgn0004381 Length:784 Species:Drosophila melanogaster
Sequence 2:NP_004789.1 Gene:KIF3B / 9371 HGNCID:6320 Length:747 Species:Homo sapiens


Alignment Length:791 Identity:366/791 - (46%)
Similarity:507/791 - (64%) Gaps:73/791 - (9%)


- Green bases have known domain annotations that are detailed below.


  Fly    17 NECVQVVVRCRPMSNRERSERSPEVVNVYPNRGVVELQNVVDGNKEQRKVFTYDAAYDASATQTT 81
            :|.|:||||||||:.:|::....:||:|....|.|.::|......|..|.||:||.||.:|.|..
Human     7 SESVRVVVRCRPMNGKEKAASYDKVVDVDVKLGQVSVKNPKGTAHEMPKTFTFDAVYDWNAKQFE 71

  Fly    82 LYHEVVFPLVSSVLEGFNGCIFAYGQTGTGKTFTMEGVRGNDELMGIIPRTFEQIWLHINRTENF 146
            ||.|...|||.|||:||||.||||||||||||:||||:||:.|..|:||.:|:.|:.||:|::|.
Human    72 LYDETFRPLVDSVLQGFNGTIFAYGQTGTGKTYTMEGIRGDPEKRGVIPNSFDHIFTHISRSQNQ 136

  Fly   147 QFLVDVSYLEIYMEELRDLL-KPNSKHLEVRER-GSGVYVPNLHAINCKSVEDMIKVMQVGNKNR 209
            |:||..||||||.||:|||| |..:|.||::|| .:||||.:|.:...|||:::..||.|||:||
Human   137 QYLVRASYLEIYQEEIRDLLSKDQTKRLELKERPDTGVYVKDLSSFVTKSVKEIEHVMNVGNQNR 201

  Fly   210 TVGFTNMNEHSSRSHAIFMIKIEMCDT---ETNTIKVGKLNLIDLAGSERQSKTGASAERLKEAS 271
            :||.||||||||||||||:|.||..:.   ..|.|:||||||:||||||||:||||..||||||:
Human   202 SVGATNMNEHSSRSHAIFVITIECSEVGLDGENHIRVGKLNLVDLAGSERQAKTGAQGERLKEAT 266

  Fly   272 KINLALSSLGNVISALAE-SSPHVPYRDSKLTRLLQDSLGGNSKTIMIANIGPSNYNYNETLTTL 335
            ||||:||:||||||||.: .|.|:||||||||||||||||||:||:|:||:||::||..||||||
Human   267 KINLSLSALGNVISALVDGKSTHIPYRDSKLTRLLQDSLGGNAKTVMVANVGPASYNVEETLTTL 331

  Fly   336 RYASRAKSIQNQPIKNEDPQDAKLKEYQEEIERL-----KRLIGPQQQQR------------SEK 383
            |||:|||:|:|:|..||||:||.|:|:||||.||     ||.||.::::.            .|:
Human   332 RYANRAKNIKNKPRVNEDPKDALLREFQEEIARLKAQLEKRSIGRRKRREKRREGGGSGGGGEEE 396

  Fly   384 QVTAKKQRVKKPKKETVTKEMSDSLQVSTIEQPVEDDSDPEGAESESDKENEAEVAKSNEELERE 448
            :...::...:...|:...:|..:.|::.. ...|||.|.....:....||.|    |..|:|.||
Human   397 EEEGEEGEEEGDDKDDYWREQQEKLEIEK-RAIVEDHSLVAEEKMRLLKEKE----KKMEDLRRE 456

  Fly   449 RVENSKLAAKLAELEGQLVRGGKNLLDTYSERQIELEKKLVEIAERKKREIEIQQQLELQEETTL 513
            :.....|.||:..:|.:|:.||||::|..:|:|..||:|..||||:|:||.|||||:|.::|.||
Human   457 KDAAEMLGAKIKAMESKLLVGGKNIVDHTNEQQKILEQKRQEIAEQKRREREIQQQMESRDEETL 521

  Fly   514 EIRERNVSLEQEVELKKRKLSKCYAKYLALQQELNDCKSDHNQDLRELEMAQNELVKELKRQLLI 578
            |::|...||:|||::|.:||.|.::|..|::.|::|.:.:|.::.:|||..||||.:|||.:.||
Human   522 ELKETYSSLQQEVDIKTKKLKKLFSKLQAVKAEIHDLQEEHIKERQELEQTQNELTRELKLKHLI 586

  Fly   579 IDNFVPIEVKQRLYTQAKYDEEQEEWKFSSMSLPTPPGGDGKFSSKRPVSHPQRRRPTSEYALQE 643
            |:||:|:|.|.::..:|.:|||::.||...::..     :.:...|||||....:||.|::|...
Human   587 IENFIPLEEKSKIMNRAFFDEEEDHWKLHPITRL-----ENQQMMKRPVSAVGYKRPLSQHARMS 646

  Fly   644 AKSNSPSSLRFKSENIVNYELEMPCRTTQEYRTPKVSASLQAVLAQAMQTGGDDIDIVDSHTNSL 708
            ......:  |:::||||..||:||.|||::|..|.::..:||.|..|:|    |.|.:....:|.
Human   647 MMIRPEA--RYRAENIVLLELDMPSRTTRDYEGPAIAPKVQAALDAALQ----DEDEIQVDASSF 705

  Fly   709 RSRLENIINANANGGAGPGAGVAVGSSIPNVRNIKSSRGLPSAASNLDSNRRPPTGRLPAKKPAS 773
            .|      .||....|.|.:|...|||       .||.|.|  ||.|                  
Human   706 ES------TANKKSKARPKSGRKSGSS-------SSSSGTP--ASQL------------------ 737

  Fly   774 AYPKARGLVNK 784
             ||::||||.|
Human   738 -YPQSRGLVPK 747

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Klp68DNP_001261726.1 Motor_domain 18..344 CDD:277568 204/331 (62%)
KISc 20..351 CDD:214526 206/336 (61%)
GBP_C <479..576 CDD:303769 47/96 (49%)
coiled coil 547..558 CDD:293879 2/10 (20%)
KIF3BNP_004789.1 KISc_KIF3 8..340 CDD:276822 204/331 (62%)
Smc <352..>614 CDD:224117 100/266 (38%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 374..412 4/37 (11%)
Globular 580..747 69/211 (33%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 699..747 23/81 (28%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165146961
Domainoid 1 1.000 229 1.000 Domainoid score I2476
eggNOG 1 0.900 - - E2759_KOG4280
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H55849
Inparanoid 1 1.050 613 1.000 Inparanoid score I915
Isobase 1 0.950 - 0 Normalized mean entropy S1573
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D145782at33208
OrthoFinder 1 1.000 - - FOG0002745
OrthoInspector 1 1.000 - - otm41123
orthoMCL 1 0.900 - - OOG6_101005
Panther 1 1.100 - - LDO PTHR24115
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2170
SonicParanoid 1 1.000 - - X1829
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1615.740

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