Protein Alignment Klp68D and KIP2

DIOPT Version :10

• Sequence 1: NP_524029.2
• Gene: Klp68D / 39332
• FlyBaseID: FBgn0004381
• Length: 784
• Species: Drosophila melanogaster
• Sequence 2: NP_015170.1
• Gene: KIP2 / 855948
• SGDID: S000006076
• Length: 706
• Species: Saccharomyces cerevisiae
• Alignment Length: 577
• Identity: 169/577 - (29%)
• Similarity: 264/577 - (45%)
• Gaps: 131/577 - (22%)

  Fly    67 FTYDAAYDASATQTTLYHEVVFPLVSSVLEGFNGCIFAYGQTGTGKTFTMEGVRGNDELMGIIPR 131
            |.:|..:.:..|...:|.....|::..:|.|||..|||||.||:||||||.   ||::.:|:||.
Yeast   163 FKFDHVFASHCTNLEVYERTSKPMIDKLLMGFNATIFAYGMTGSGKTFTMS---GNEQELGLIPL 224

  Fly   132 TFEQIWLHI---NRTENFQFLVDVSYLEIYMEELRDLL--------------------KPNSK-- 171
            :...::.:|   :...:.:|.|.:||||||.|.:.|||                    |.||.
Yeast   225 SVSYLFTNIMEQSMNGDKKFDVIISYLEIYNERIYDLLESGLEESGSRISTPSRLYMSKSNSNGL 289

  Fly   172 --HLEVRERGS-GVYVPNLHAINCKSVEDMIKVMQVGNKNRTVGFTNMNEHSSRSHAIFMIKIEM 233
              .|::|:... ||.|..|....|:|.|::::.:.||:|:|.:|.|:.|..|||||||.:|::..
Yeast   290 GVELKIRDDSQYGVKVIGLTERRCESSEELLRWIAVGDKSRKIGETDYNARSSRSHAIVLIRLTS 354

  Fly   234 CDTETNTIKVGKLNLIDLAGSERQSKTGASAERLKEASKINLALSSLGNVISALAE--------- 289
            .:.:..|.:...|:|.|||||||  .|| ..||.||.|.||.:|.:||.|||.|:.
Yeast   355 TNVKNGTSRSSTLSLCDLAGSER--ATG-QQERRKEGSFINKSLLALGTVISKLSADKMNSVGSN 416

  Fly   290 --------------------SSP--HVPYRDSKLTRLLQDSLGGNSKTIMIANIGPSNYNYNETL 332
                                :||  |:||||||||||||.:|.|:|....|..:...|....||:
Yeast   417 IPSPSASGSSSSSGNATNNGTSPSNHIPYRDSKLTRLLQPALSGDSIVTTICTVDTRNDAAAETM 481

  Fly   333 TTLRYASRAKSI-----QNQPIKNEDPQDAKLKEYQEEIERLKRLIGPQQQQRSEKQVTAKKQRV 392
            .|||:|||||::     :...|.|.:....|    ...||.|:|.:..|::..||.:   .:..:
Yeast   482 NTLRFASRAKNVALHVSKKSIISNGNNDGDK----DRTIELLRRQLEEQRRMISELK---NRSNI 539

  Fly   393 KKPKKETVTKEMSDSLQVSTIEQPVEDDSDPEGAESESDKENEAEVAKSNEELERERVENSKLAA 457
            .:|    :||..::|.....  :...:|.||                    .|...|.||..|..
Yeast   540 GEP----LTKSSNESTYKDI--KATGNDGDP--------------------NLALMRAENRVLKY 578

  Fly   458 KLAELEGQLVRGGKNLLDTYSERQIELEKKLVEIAERKKREIEIQQQLELQEETTLEIRERNVSL 522
            ||...|        .|||          |.:|::.:  ...:||.:.|..:..|.||.:.:  .|
Yeast   579 KLENCE--------KLLD----------KDVVDLQD--SEIMEIVEMLPFEVGTLLETKFQ--GL 621

  Fly   523 EQEVELKKRKLSKCYAKYLALQQ------ELNDCKSDHNQDLRELEMAQNELVKELK 573
            |.::...::...|...|.:||::      .|..|......:|:::...::::::.|:
Yeast   622 ESQIRQYRKYTQKLEDKIMALEKSGHTAMSLTGCDGTEVIELQKMLERKDKMIEALQ 678

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp68D	NP_524029.2	KISc	20..351	CDD:214526	124/347 (36%)
		Smc	<431..>580	CDD:440809	29/149 (19%)
KIP2	NP_015170.1	KISc_CENP_E	102..493	CDD:276825	123/335 (37%)
		SMC_prok_B	<445..>698	CDD:274008	72/289 (25%)