Protein Alignment Klp68D and SMY1

DIOPT Version :9

• Sequence 1: NP_001261726.1
• Gene: Klp68D / 39332
• FlyBaseID: FBgn0004381
• Length: 784
• Species: Drosophila melanogaster
• Sequence 2: NP_012844.1
• Gene: SMY1 / 853783
• SGDID: S000001562
• Length: 656
• Species: Saccharomyces cerevisiae
• Alignment Length: 693
• Identity: 167/693 - (24%)
• Similarity: 294/693 - (42%)
• Gaps: 164/693 - (23%)

  Fly    20 VQVVVRCRPMSNRERSERSPEVVNVYPNRGVVELQNVV-DGNKEQRKVFTYDAAYDASATQTTLY 83
            ::|::|..|....:.:| |...::.|.|..:....|.: :..||....|.:|..:||:|||..:.
Yeast    28 IEVILRAIPEKGLQNNE-STFKIDPYENTVLFRTNNPLHETTKETHSTFQFDKVFDANATQEDVQ 91

  Fly    84 HEVVFPLVSSVLEGFNGCIFAYGQTGTGKTFTMEGVRGNDELMGIIPRTFEQIWLHINRTENFQ- 147
            ..:|.|:::.||.|:||.:..||.:.:||::::   .|:.|..||:|...:.::..:.:.|..:
Yeast    92 KFLVHPIINDVLNGYNGTVITYGPSFSGKSYSL---IGSKESEGILPNICKTLFDTLEKNEETKG 153

  Fly   148 --FLVDVSYLEIYMEELRDLL--KPNSKHLEVRERGS--GVYVPNLHAINCKSVEDMIKVMQ--- 203
              |.|.|...|||||:..|||  .|..|.|::....|  .:.:.::...:..|.||:...:|
Yeast   154 DSFSVSVLAFEIYMEKTYDLLVPLPERKPLKLHRSSSKMDLEIKDICPAHVGSYEDLRSYIQAVQ 218

  Fly   204 -VGNK----NRTVGFTNMNEHSSRSHAIFMIKIEMCDTETNTIKVGKLNLIDLAGSERQSKTGAS 263
             |||:    ::|        ..||||.:|.:.:|..:.:.:.:|...|.|:||.|:|:..|...|
Yeast   219 NVGNRMACGDKT--------ERSRSHLVFQLHVEQRNRKDDILKNSSLYLVDLHGAEKFDKRTES 275

  Fly   264 AERLKEASKINLALSSLGNVISAL----------AESSPHVPYRDSKLTRLLQDSLGGNSKTIMI 318
            ........|:|.::.:|.|.:.:|          |:.|....||:|:||.:|:||||||.||.:|
Yeast   276 TLSQDALKKLNQSIEALKNTVRSLSMKERDSAYSAKGSHSSAYRESQLTEVLKDSLGGNRKTKVI 340

  Fly   319 ANIGPSNYNYNETLTTLRYASRAKSIQNQPIKNEDP-----------QDAKLKE---------YQ 363
            .....|  |...||:||.:....:.|.|:...|...           ||.|:|:         .:
Yeast   341 LTCFLS--NVPTTLSTLEFGDSIRQINNKVTDNTTGLNLKKKMDLFIQDMKIKDDNYVAQINILK 403

  Fly   364 EEIERLKRLIGPQQQQRSEKQV--TAKKQRVK-KPKKETVTKEMSDSLQVSTIEQPVEDDSDPEG 425
            .||:.||.|......:..||::  ..||:.:| |.:.:::|:.:|.    ||.|.|
Yeast   404 AEIDSLKSLHNKSLPEDDEKKMLENTKKENIKLKLQLDSITQLLSS----STNEDP--------- 455

  Fly   426 AESESDKENEAEVAKSNEELERERVE-NSKLAAKLAELEGQLVRGGKNLLDTYSERQIELEKKLV 489
                            |..::.|..| .:|...::|:||...            :||:....||
Yeast   456 ----------------NNRIDEEVSEILTKRCEQIAQLELSF------------DRQMNSNSKL- 491

  Fly   490 EIAERKKREIEIQQQLELQEETTLEIRERNVSLEQEVELKKRKLSKCYAKYLALQQELNDCKSDH 554
                        ||:||.::.....:...||.|.::::|::|::.:.......|:.||    ..|
Yeast   492 ------------QQELEYKKSKEEALESMNVRLLEQIQLQEREIQELLTTNAILKGEL----ETH 540

  Fly   555 NQDLRELEMAQNELVKELKRQLLIIDNFVPIEVKQRLYTQAKYDEEQEEWKFSSMSLPTPPGGDG 619
            .    :|...::|.:|.|:..:                         :|...:..::|:|..|..
Yeast   541 T----KLTETRSERIKSLESSV-------------------------KELSLNKSAIPSPRRGSM 576

  Fly   620 KFSSKRPVSHPQRRRPTSEYALQEAK--SNSPSSLRFKSENIV 660
            ..||...:.|           ::|..  ||||.|....|:.:|
Yeast   577 SSSSGNTMLH-----------IEEGSEISNSPWSANTSSKPLV 608

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp68D	NP_001261726.1	Motor_domain	18..344	CDD:277568	100/349 (29%)
		KISc	20..351	CDD:214526	102/356 (29%)
		GBP_C	<479..576	CDD:303769	21/96 (22%)
		coiled coil	547..558	CDD:293879	2/10 (20%)
SMY1	NP_012844.1	KISc_KHC_KIF5	25..364	CDD:276820	100/349 (29%)
		Smc	<254..568	CDD:224117	90/402 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910