DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Klp68D and Kif3c

DIOPT Version :9

Sequence 1:	NP_001261726.1	Gene:	Klp68D / 39332	FlyBaseID:	FBgn0004381	Length:	784	Species:	Drosophila melanogaster
Sequence 2:	NP_445938.1	Gene:	Kif3c / 85248	RGDID:	621538	Length:	796	Species:	Rattus norvegicus

Alignment Length:	724	Identity:	313/724 - (43%)
Similarity:	453/724 - (62%)	Gaps:	77/724 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 SSQTPNECVQVVVRCRPMSNRERSERSPEVVNVYPNRGVVELQNVVDGNKEQRKVFTYDAAYDAS 76
            |....:|.::||.||||:|.:|.:....:::.:....|.|.|:|......|..|.||:||.||||
  Rat     3 SKTKASEALKVVARCRPLSRKEEAAGHEQILTMDVKLGQVTLRNPRAAPGELPKTFTFDAVYDAS 67

  Fly    77 ATQTTLYHEVVFPLVSSVLEGFNGCIFAYGQTGTGKTFTMEGVRGNDELMGIIPRTFEQIWLHIN 141
            :.|..||.|.|.||:.|||:||||.:|||||||||||:||:|.....||.|:||..||.|:.||:
  Rat    68 SKQADLYDETVRPLIDSVLQGFNGTVFAYGQTGTGKTYTMQGTWVEPELRGVIPNAFEHIFTHIS 132

  Fly   142 RTENFQFLVDVSYLEIYMEELRDLL-KPNSKHLEVRER-GSGVYVPNLHAINCKSVEDMIKVMQV 204
            |::|.|:||..||||||.||:|||| |...|.||::|. .:|||:.:|.:...|:|:::..||.:
  Rat   133 RSQNQQYLVRASYLEIYQEEIRDLLSKEPGKRLELKENPETGVYIKDLSSFVTKNVKEIEHVMNL 197

  Fly   205 GNKNRTVGFTNMNEHSSRSHAIFMIKIEMCDTET---NTIKVGKLNLIDLAGSERQSK------- 259
            ||:.|.||.|:|||.||||||||:|.:|..:..:   :.|:||||||:||||||||:|
  Rat   198 GNQARAVGSTHMNEVSSRSHAIFVITVECSERGSDGQDHIRVGKLNLVDLAGSERQNKAGPNTPG 262

  Fly   260 -------------------TGASAERLKEASKINLALSSLGNVISALA-ESSPHVPYRDSKLTRL 304
                               :|:|.||.||||||||:||:|||||:||| ..|.|:||||||||||
  Rat   263 GPATQSTAGGGGGGGGTSGSGSSGERPKEASKINLSLSALGNVIAALAGNRSTHIPYRDSKLTRL 327

  Fly   305 LQDSLGGNSKTIMIANIGPSNYNYNETLTTLRYASRAKSIQNQPIKNEDPQDAKLKEYQEEIERL 369
            ||||||||:||||:|.:||::::|:|:|:|||:|:|||:|:|:|..||||:|..|:|:||||.||
  Rat   328 LQDSLGGNAKTIMVATLGPASHSYDESLSTLRFANRAKNIKNKPRVNEDPKDTLLREFQEEIARL 392

  Fly   370 KR------LIGPQQQQRS---EKQVTA----------------------KKQRVKKPKKE-TVTK 402
            |.      ::|.:.:::|   :|.|:|                      ...|..:|..| .:.|
  Rat   393 KAQLEKKGMLGKRPRRKSSRRKKAVSAPAGYPEGAVIEAWVAEEEDDNNNNHRPPQPTLEAALEK 457

  Fly   403 EMSDSLQVSTIEQPVEDD----SDPEGAESESDKENEAEVAKSNEELERERVENSKLAAKLAELE 463
            .|.:.||..  ::.:|::    .|.....||..::...|..|..|:|:||:.....||||...:|
  Rat   458 NMENYLQEQ--KERLEEEKAAIQDDRSLVSEEKQKLLEEKEKMLEDLKREQQATELLAAKYKAME 520

  Fly   464 GQLVRGGKNLLDTYSERQIELEKKLVEIAERKKREIEIQQQLELQEETTLEIRERNVSLEQEVEL 528
            .:|:.||:|::|..:|:|..||.|..||||:|:||.|:||::.|::|.|:|:|....||:||||:
  Rat   521 SKLLIGGRNIMDHTNEQQKMLELKRQEIAEQKRREREMQQEMLLRDEETMELRGTYSSLQQEVEV 585

  Fly   529 KKRKLSKCYAKYLALQQELNDCKSDHNQDLRELEMAQNELVKELKRQLLIIDNFVPIEVKQRLYT 593
            |.:||.|.|||..|::.|:.|...::.:..::||.||||..:|||.:.|||:||:|.|.|.::..
  Rat   586 KTKKLKKLYAKLQAVKAEIQDQHEEYIRVRQDLEEAQNEQTRELKLKYLIIENFIPPEEKNKIMN 650

  Fly   594 QAKYDEEQEEWKFSSMSLPTPPGGDGKFSSKRPVSHPQRRRPTSEYA-LQEAKSNSPSSLRFKSE 657
            :...|.|:|:|||..:   .|.|.:.....|||.|....:||.|:|| :..|..:.|   |:::|
  Rat   651 RLFLDCEEEQWKFQPL---VPAGVNNSQMKKRPTSAVGYKRPISQYARVAMAMGSHP---RYRAE 709

  Fly   658 NIVNYELEM 666
            ||:..||::
  Rat   710 NIMFLELDV 718

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Klp68D	NP_001261726.1	Motor_domain	18..344	CDD:277568	185/357 (52%)
		KISc	20..351	CDD:214526	187/362 (52%)
		GBP_C	<479..576	CDD:303769	45/96 (47%)
		coiled coil	547..558	CDD:293879	1/10 (10%)
Kif3c	NP_445938.1	KISc_KIF3	9..367	CDD:276822	185/357 (52%)
		Kinesin	16..367	CDD:278646	182/350 (52%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	251..292		9/40 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	397..421		5/23 (22%)
		GBP_C	<463..571	CDD:303769	40/109 (37%)
		coiled coil	540..551	CDD:293879	6/10 (60%)
		coiled coil	560..571	CDD:293879	4/10 (40%)
		Globular. /evidence=ECO:0000255	633..793		33/92 (36%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	754..796
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166340625
Domainoid	1	1.000	225	1.000	Domainoid score	I2453
eggNOG	1	0.900	-	-		E2759_KOG4280
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	610	1.000	Inparanoid score	I884
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D145782at33208
OrthoFinder	1	1.000	-	-		FOG0002745
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101005
Panther	1	1.100	-	-	O	PTHR24115
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1829
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	13	12.760