Protein Alignment Klp68D and KIP1

DIOPT Version :10

• Sequence 1: NP_524029.2
• Gene: Klp68D / 39332
• FlyBaseID: FBgn0004381
• Length: 784
• Species: Drosophila melanogaster
• Sequence 2: NP_009490.1
• Gene: KIP1 / 852216
• SGDID: S000000159
• Length: 1111
• Species: Saccharomyces cerevisiae
• Alignment Length: 890
• Identity: 222/890 - (24%)
• Similarity: 381/890 - (42%)
• Gaps: 230/890 - (25%)

  Fly    15 TPNEC----------VQVVVRCRPMSNRERSERSPEVVNVYPNRGVVELQNVVDGN------KEQ 63
            ||..|          :.|.||||..:.||..|:|..|::....:|    :.::..|      ...
Yeast    38 TPPTCNNGAATSDSNIHVYVRCRSRNKREIEEKSSVVISTLGPQG----KEIILSNGSHQSYSSS 98

  Fly    64 RKVFTYDAAYDASATQTTLYHEVVFPLVSSVLEGFNGCIFAYGQTGTGKTFTMEG-------VRG 121
            :|.:.:|..:.|.:.|.|:::......:..:|.|:|..||||||||||||:||.|       |:.
Yeast    99 KKTYQFDQVFGAESDQETVFNATAKNYIKEMLHGYNCTIFAYGQTGTGKTYTMSGDINILGDVQS 163

  Fly   122 NDELM-----GIIPRTFEQIWLHINRTENFQFLVDVSYLEIYMEELRDLLKP--------NSKHL 173
            .|.|:     |||||....::..:: :.|.::.|.:|:||:|.|.|:|||..        |....
Yeast   164 TDNLLLGEHAGIIPRVLVDLFKELS-SLNKEYSVKISFLELYNENLKDLLSDSEDDDPAVNDPKR 227

  Fly   174 EVR-----ERGSGVYVPNLHAINCKSVEDMIKVMQVGNKNRTVGFTNMNEHSSRSHAIFMIKIEM 233
            ::|     ...|.:.|..:..|...|..:.:.::..|:..|.|..|..|:.|||||.:|.|...:
Yeast   228 QIRIFDNNNNNSSIMVKGMQEIFINSAHEGLNLLMQGSLKRKVAATKCNDLSSRSHTVFTITTNI 292

  Fly   234 CDTET-------NTIKVGKLNLIDLAGSERQSKTGASAERLKEASKINLALSSLGNVISALAESS 291
            .:.::       |.:|:|||||:||||||..:::||..:|.:||..||.:|.:||.||:||.:.|
Yeast   293 VEQDSKDHGQNKNFVKIGKLNLVDLAGSENINRSGAENKRAQEAGLINKSLLTLGRVINALVDHS 357

  Fly   292 PHVPYRDSKLTRLLQDSLGGNSKTIMIANIGPSNYNYNETLTTLRYASRAKSIQNQPIKNED-PQ 355
            .|:|||:|||||||||||||.:||.:||.|.|:..:..||.:||.||:|||||:|.|..|:. .:
Yeast   358 NHIPYRESKLTRLLQDSLGGMTKTCIIATISPAKISMEETASTLEYATRAKSIKNTPQVNQSLSK 422

  Fly   356 DAKLKEYQEEIERLKR----------LIGPQQQ-----------QRSEKQVTAKKQRVKKPKKET 399
            |..||:|.:|||:|:.          :...|.|           .....::...::::||.|:..
Yeast   423 DTCLKDYIQEIEKLRNDLKNSRNKQGIFITQDQLDLYESNSILIDEQNLKIHNLREQIKKFKENY 487

  Fly   400 VTKEMSDSLQVSTIEQPVED---------DSDPEGAESESDKENEAEVAKSNEELERE--RVENS 453
            :     :.|.::.:.|..::         :.|.....||..|.:...:...||.:::.  .:|||
Yeast   488 L-----NQLDINNLLQSEKEKLIAIIQNFNVDFSNFYSEIQKIHHTNLELMNEVIQQRDFSLENS 547

  Fly   454 K--------LAAKLAELEGQLVRGGKNLLDTYSERQIELEKKLVEIAERK------KREIEIQQQ 504
            :        :..|:::...|.:...:..|:.|:.:..|:.|.:.|...|.      |.:..::..
Yeast   548 QKQYNTNQNMQLKISQQVLQTLNTLQGSLNNYNSKCSEVIKGVTEELTRNVNTHKAKHDSTLKSL 612

  Fly   505 LELQEETTLEIRERNV---SLEQEVELKKRKLSKCYAKYLALQQELNDCKSDHNQDLREL----- 561
            |.:  .|.|.:.:.|.   |:...:|:.:...:..|.|      :||:....|.|.|:.|
Yeast   613 LNI--TTNLLMNQMNELVRSISTSLEIFQSDSTSHYRK------DLNEIYQSHQQFLKNLQNDIK 669

  Fly   562 ---------------EMAQN--------------------ELVKELKRQL------LIIDNFVPI 585
                           |::||                    :|:||...::      ||.:..:..
Yeast   670 SCLDSIGSSILTSINEISQNCTTNLNSMNVLIENQQSGSSKLIKEQDLEIKKLKNDLINERRISN 734

  Fly   586 EVKQRLYTQAKY-------------DE---------------EQEEW-KFSSMSLPTPPGGDGKF 621
            :..|:|....:|             ||               :|:.| |.:|:...|
Yeast   735 QFNQQLAEMKRYFQDHVSRTRSEFHDELNKCIDNLKDKQSKLDQDIWQKTASIFNET-------- 791

  Fly   622 SSKRPVSHPQRRRPTSEYALQEAKSNSPSSLRFKSEN---------------IVNYELEMPCRTT 671
                            :..:.:..|:|.:||...:||               :::....|....:
Yeast   792 ----------------DIVVNKIHSDSIASLAHNAENTLKTVSQNNESFTNDLISLSRGMNMDIS 840

  Fly   672 QEYRTPKVSASLQAVLAQAMQTGGDDIDIVDSHTNSLRSRLENII 716
            .:.|:..::..|..:.....:|.|||..|..:...:...:.:|||
Yeast   841 SKLRSLPINEFLNKISQTICETCGDDNTIASNPVLTSIKKFQNII 885

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp68D	NP_524029.2	KISc	20..351	CDD:214526	136/368 (37%)
		Smc	<431..>580	CDD:440809	37/213 (17%)
KIP1	NP_009490.1	KISc_BimC_Eg5	50..419	CDD:276815	137/373 (37%)
		235kDa-fam	<423..>948	CDD:130673	82/500 (16%)
		AAA_13	<562..>741	CDD:463796	31/186 (17%)