DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Klp68D and Kif3a

DIOPT Version :9

Sequence 1:	NP_001261726.1	Gene:	Klp68D / 39332	FlyBaseID:	FBgn0004381	Length:	784	Species:	Drosophila melanogaster
Sequence 2:	XP_006246409.1	Gene:	Kif3a / 84392	RGDID:	621536	Length:	726	Species:	Rattus norvegicus

Alignment Length:	739	Identity:	295/739 - (39%)
Similarity:	447/739 - (60%)	Gaps:	77/739 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 SQTPNEC--VQVVVRCRPMSNRERSERSPEVVNVYPNRGVVELQNVVDGNKEQRKVFTYDAAYDA 75
            |:.|..|  |:|||||||::.||:|....:.|:|...||.:.:.. .|.:.|..|.||:|..:..
  Rat     6 SEKPESCDNVKVVVRCRPLNEREKSMCYRQAVSVDEMRGTITVHK-TDSSNEPPKTFTFDTVFGP 69

  Fly    76 SATQTTLYHEVVFPLVSSVLEGFNGCIFAYGQTGTGKTFTMEGVRGNDELMGIIPRTFEQIWLHI 140
            .:.|..:|:....|::.|||||:||.|||||||||||||||||||....|.|:||.:|..|:.||
  Rat    70 ESKQLDVYNLTARPIIDSVLEGYNGTIFAYGQTGTGKTFTMEGVRAVPGLRGVIPNSFAHIFGHI 134

  Fly   141 NRTE-NFQFLVDVSYLEIYMEELRDLL-KPNSKHLEVRERGS-GVYVPNLHAINCKSVEDMIKVM 202
            .:.| :.:|||.|||||||.||:|||| |..::.|||:||.. |||:.:|.|....:.:||.::|
  Rat   135 AKAEGDTRFLVRVSYLEIYNEEVRDLLGKDQTQRLEVKERPDVGVYIKDLSAYVVNNADDMDRIM 199

  Fly   203 QVGNKNRTVGFTNMNEHSSRSHAIFMIKIEMCDTETN---TIKVGKLNLIDLAGSERQSKTGASA 264
            .:|:|||:||.||||||||||||||.|.||..:...:   .:::|||:|:||||||||:||||:.
  Rat   200 TLGHKNRSVGATNMNEHSSRSHAIFTITIECSEKGVDGNMHVRMGKLHLVDLAGSERQAKTGATG 264

  Fly   265 ERLKEASKINLALSSLGNVISALAE-SSPHVPYRDSKLTRLLQDSLGGNSKTIMIANIGPSNYNY 328
            :|||||:||||:||:||||||||.: .|.|||||:|||||||||||||||||:|.|||||::|||
  Rat   265 QRLKEATKINLSLSTLGNVISALVDGKSTHVPYRNSKLTRLLQDSLGGNSKTMMCANIGPADYNY 329

  Fly   329 NETLTTLRYASRAKSIQNQPIKNEDPQDAKLKEYQEEIERLKR------------LIGPQQQQRS 381
            :||::|||||:|||:|:|:...||||:||.|:::|:|||.||:            :.|.::....
  Rat   330 DETISTLRYANRAKNIKNKARINEDPKDALLRQFQKEIEELKKKLEEGEEVSGSDISGSEEDDNE 394

  Fly   382 EKQVTAKKQRVKKPKKETVTKEMSDSLQVSTIEQPVED-----------------------DSDP 423
            |.::....::.|| ::.:.:...||| ..|.||:|:::                       |.:.
  Rat   395 EGELGEDGEKRKK-RRGSSSSSSSDS-TCSVIEKPLDEFLPHQAGKKKVSPDKMMEMQAKIDEER 457

  Fly   424 EGAESESDKENE------AEVAKSNEELERERVENSKLAAKLAELEGQLVRGGKNLLDTYSERQI 482
            :..|::.|.|.|      ||:.:..::|.:.:.|:..|..||:.||.:::.||.:||....|::.
  Rat   458 KALETKLDMEEEERNKARAELERREKDLLKAQQEHQSLLEKLSALEKKVIVGGVDLLAKAEEQEK 522

  Fly   483 ELEKKLVEIAERKKREIEIQQQLELQEETTLEIRERNVSLEQEVELKKRKLSKCYAKYLALQQEL 547
            .||:..:|:.||:||..:::::||.:|:..|:|.|:..||::|.:.|.:||.|.:...:|.:.|:
  Rat   523 LLEESNMELEERRKRAEQLRKELEEKEQERLDIEEKYTSLQEEAQGKTKKLKKVWTMLMAAKSEM 587

  Fly   548 NDCKSDHNQDLRELEMAQNELVKELKRQLLIIDNFVPIEVKQRLYTQAKYDEEQEEWKFSSMSLP 612
            .|.:.:|.:::..|.....:|.:||:.|:||||||:|.:.::.:.....::|:..||:...::..
  Rat   588 ADLQQEHQREIEGLLENIRQLSRELRLQMLIIDNFIPQDYQEMIENYVHWNEDIGEWQLKCVAYT 652

  Fly   613 TPPGGDGKFSSKRPVSHPQRRRP----TSEYALQEAKSNSPSSLRFKSENIVNYELEMPCRTTQE 673
                 ......:.||...:.|.|    .|...|...:.:...||         .:||.| ||::.
  Rat   653 -----GNNMRKQTPVPDKKERDPFEVDLSHVYLAYTEESLRQSL---------MKLERP-RTSKG 702

  Fly   674 YRTPKV-----SASLQAVLAQAMQ 692
            ...||.     ||..:.|:...:|
  Rat   703 KARPKTGRRKRSAKPETVIDSLLQ 726

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Klp68D	NP_001261726.1	Motor_domain	18..344	CDD:277568	190/334 (57%)
		KISc	20..351	CDD:214526	191/337 (57%)
		GBP_C	<479..576	CDD:303769	29/96 (30%)
		coiled coil	547..558	CDD:293879	2/10 (20%)
Kif3a	XP_006246409.1	KISc_KIF3	13..345	CDD:276822	189/332 (57%)
		Kinesin	20..345	CDD:278646	185/325 (57%)
		CENP-F_leu_zip	434..574	CDD:287450	37/139 (27%)
		GBP_C	<446..611	CDD:303769	45/164 (27%)
		coiled coil	597..608	CDD:293879	1/10 (10%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4280
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D145782at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101005
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.720