Protein Alignment Klp68D and cenpe

DIOPT Version :10

• Sequence 1: NP_524029.2
• Gene: Klp68D / 39332
• FlyBaseID: FBgn0004381
• Length: 784
• Species: Drosophila melanogaster
• Sequence 2: NP_001314688.1
• Gene: cenpe / 767754
• ZFINID: ZDB-GENE-060929-860
• Length: 2690
• Species: Danio rerio
• Alignment Length: 833
• Identity: 241/833 - (28%)
• Similarity: 370/833 - (44%)
• Gaps: 180/833 - (21%)

  Fly    15 TPNECVQVVVRCRPMSNRERSERSPEVVNVYPNRGVVELQNVVDGNKEQRKVFTYDAAYDASATQ 79
            |....|:|.||.||:..||.|| |.|.|.:| .|...:..:.:|.:..|.|.:::|..:.|:.:.
Zfish     2 TEESAVKVCVRVRPLIKREASE-SSEPVQLY-WRSDKQAIHQLDEDGAQTKSYSFDRVFSAAEST 64

  Fly    80 TTLYHEVVFPLVSSVLEGFNGCIFAYGQTGTGKTFTMEGVRGNDELMGIIPRTFEQIWLHINRTE 144
            ..||.::..|||.|.:||:||.|||||||.:||||||.|...|.   |:||.....::..|....
Zfish    65 AQLYQDIAKPLVVSAVEGYNGTIFAYGQTSSGKTFTMMGSEHNP---GVIPLAMADVFKTIKSFP 126

  Fly   145 NFQFLVDVSYLEIYMEELRDLLKPN--SKHLEVRERG-SGVYVPNLHAINCKSVEDMIKVMQVGN 206
            ..:||:.|||:|||.|.:.|||..:  .|.||:||.. ..|||.:|......|.|..:..:..|.
Zfish   127 KKEFLLRVSYMEIYNETVTDLLCDSWKRKPLEIREGNYKNVYVADLTEELVTSPEQALSWITKGE 191

  Fly   207 KNRTVGFTNMNEHSSRSHAIFMIKIEMCDTETNT--------IKVGKLNLIDLAGSERQSKTGAS 263
            |||..|.|.||:.|||||.||.:.:|..:....|        |.|..|||:||||:||.|:|||.
Zfish   192 KNRHYGKTKMNQRSSRSHTIFRMILESRERSDPTAGESADGAIIVSHLNLVDLAGAERASQTGAE 256

  Fly   264 AERLKEASKINLALSSLGNVISALAESSP--HVPYRDSKLTRLLQDSLGGNSKTIMIANIGPSNY 326
            ..|.||...||.:|.:||.||..|::.|.  .:.||||||||:||:|||||:||::|..|.|:
Zfish   257 GARFKEGCNINRSLFTLGQVIKKLSDESQKGFLNYRDSKLTRILQNSLGGNAKTVIICTITPA-- 319

  Fly   327 NYNETLTTLRYASRAKSIQNQP-IKNEDPQDAKLKEYQEEIERLKRLIGPQQQQRSEKQVTAKK- 389
            ..:||::||::||.||.::|.| :.....:.|.|:.|:.||..|||.:   |:..|..|.||.:
Zfish   320 TVDETVSTLQFASAAKRMKNDPHVTEVSDEGALLRRYRNEIVDLKRRL---QEVSSVTQTTATER 381

  Fly   390 -------------QRVKKPKKETVTKEMSDSLQVSTIEQ-------------------------- 415
                         ||.::.:.:.:||.:..|..::.|.:
Zfish   382 ESLCQLLQEKDQLQREQEDRIKNLTKLLVTSSNIALIPKVPKRRVTWGGKLLRSAHLLNEDLCST 446

  Fly   416 -------------------PVEDDSDPEGA--------ESESDKENEAEVAKSNEE----LERER 449
                               .|.:|.|...:        |...|.|..:...:|:.|    |:..|
Zfish   447 DMSFAEPYLKKRRADCSLADVGEDMDEFDSRFDFTAMEEPNMDMEMSSITVRSSSEGSHFLDSPR 511

  Fly   450 VENSKLAAKLAELEGQLVRGGKNLLDTYS-----ERQIELEKKLVEIA-----------ERKKRE 498
            .  |:|..|::.||.||.      .:|.|     |...||:.||..:.           |.|...
Zfish   512 A--SELMQKVSSLESQLE------AETQSKQIAEEMNAELQMKLSHLQNMLEAQSAPSHEEKNTI 568

  Fly   499 IEIQQQLE-LQEETTLEIRERNVSLEQEV--ELKKRKLSKCYAKYLALQQELNDCKSDHNQDLRE 560
            .|:::|:| ||.....|::||..:.|:.:  |||..:|.|...:.|..|......|.|..:.::.
Zfish   569 SELEKQMEDLQRRLETEVQERQTAEEKSISLELKVAELEKPSEELLHSQNTCERVKKDLEEAIQL 633

  Fly   561 LE---------MAQNELVKELKRQLLIIDNFVPIEVKQRLYTQAKYDEEQEEWKFSSMSLPTPPG 616
            .|         :|:.:::|          :.:.:..::....:|:.|..|:|
Zfish   634 CETVSFEKDAVIAERDMIK----------HSLDMTTEELESLKAEKDSLQKE------------- 675

  Fly   617 GDGKFSSKRPVSHP-QRRRPTSEYALQEAKSNSPSSLRFKSENIVNYELEMPCRTTQEYRTPKVS 680
            .|.....|..:... :.||...|:...|.:|........::|   |..||...:.::: ...|:.
Zfish   676 KDALQKDKDALQKDMEERRDADEFEKLEEESKRDYERELEAE---NSRLEKNLKQSED-MIQKLK 736

  Fly   681 ASLQAVLAQAMQT-----------GGDDI---------DIVDSHTNSLRSRLE 713
            |.| |:::..:|.           .|.||         .:.|:.|.||.::.|
Zfish   737 ADL-ALMSSELQKKTDLTTELQGFSGKDIVQEVTRLRRSLDDAETLSLETKKE 788

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp68D	NP_524029.2	KISc	20..351	CDD:214526	146/344 (42%)
		Smc	<431..>580	CDD:440809	43/180 (24%)
cenpe	NP_001314688.1	KISc_CENP_E	6..337	CDD:276825	144/337 (43%)
		SMC_prok_B	512..1266	CDD:274008	65/313 (21%)
		SMC_prok_B	<917..1759	CDD:274008
		Smc	<1486..>2047	CDD:440809
		sbcc	1716..2415	CDD:129705