Protein Alignment Klp68D and KIF9

DIOPT Version :9

• Sequence 1: NP_001261726.1
• Gene: Klp68D / 39332
• FlyBaseID: FBgn0004381
• Length: 784
• Species: Drosophila melanogaster
• Sequence 2: XP_005265445.1
• Gene: KIF9 / 64147
• HGNCID: 16666
• Length: 823
• Species: Homo sapiens
• Alignment Length: 846
• Identity: 216/846 - (25%)
• Similarity: 324/846 - (38%)
• Gaps: 245/846 - (28%)

  Fly     5 SRRPGT---GSSQTPNECVQVVVRCRP-------MSNRERSERSPEV-VNVYPNRGVVELQNVVD 58
            ||.||.   |......:.|...||.:|       |......:||.:: :.....||||
Human    22 SRVPGASLPGERMGTRKKVHAFVRVKPTDDFAHEMIRYGDDKRSIDIHLKKDIRRGVV------- 79

  Fly    59 GNKEQRKVFTYDAA-YDASATQTTLYHEVVFPLVSSVLEGFNGCIFAYGQTGTGKTFTMEGVRGN 122
            .|::....|..|.. :|||  |..:|..|...:||..|:|:||.|..|||||.|||:||.|...|
Human    80 NNQQTDWSFKLDGVLHDAS--QDLVYETVAKDVVSQALDGYNGTIMCYGQTGAGKTYTMMGATEN 142

  Fly   123 DELMGIIPRTFEQIWLHINRTENFQFLVDVSYLEIYMEELRDLLK------PNSKHLEVRERGSG 181
            .:..||:||..:|::..|.........|.|||||||.|.|.|||.      |:...:.:.|...|
Human   143 YKHRGILPRALQQVFRMIEERPTHAITVRVSYLEIYNESLFDLLSTLPYVGPSVTPMTIVENPQG 207

  Fly   182 VYVPNLHAINCKSVEDMIKVMQVGNKNRTVGFTNMNEHSSRSHAIFMIKIEMCDTETNTIK---- 242
            |::..|........||...::..|..||.:....||::|||||.||.|.:|   ..:.|:.
Human   208 VFIKGLSVHLTSQEEDAFSLLFEGETNRIIASHTMNKNSSRSHCIFTIYLE---AHSRTLSEEKY 269

  Fly   243 -VGKLNLIDLAGSERQSKTGASAERLKEASKINLALSSLGNVISALAESS-PHVPYRDSKLTRLL 305
             ..|:||:|||||||..|:|:..:.||||:.||.:||.|...|.||.:.. .|:|:|..|||..|
Human   270 ITSKINLVDLAGSERLGKSGSEGQVLKEATYINKSLSFLEQAIIALGDQKRDHIPFRQCKLTHAL 334

  Fly   306 QDSLGGNSKTIMIANIGPSNYNYNETLTTLRYASRAKSIQNQPIKNE------------------ 352
            :||||||...:::.||........|||::||:|||.|.:..:|..||
Human   335 KDSLGGNCNMVLVTNIYGEAAQLEETLSSLRFASRMKLVTTEPAINEKYDAERMVKNLEKELALL 399

  Fly   353 ------------------DPQD--------AKLKEYQE---------EIERLK------RLIGPQ 376
                              ||.|        ::::.|.|         .:.::|      |::..|
Human   400 KQELAIHDSLTNRTFVTYDPMDEIQIAEINSQVRRYLEGTLDEIDIISLRQIKEVFNQFRVVLSQ 464

  Fly   377 QQQRSEKQVTAKKQRV----------------------------------------KKPKKETVT 401
            |:|..|..:..|...:                                        .||.|:..:
Human   465 QEQEVESTLRRKYTLIDRNDFAAISAIQKAGLVDVDGHLVGEPEGQNFGLGVAPFSTKPGKKAKS 529

  Fly   402 KEMSDSLQVSTIEQPVEDDSDPEGAESESDKENEAEVAKSNEEL---------------ERERVE 451
            |:        |.::|:...:..|||.|..:.::...|:.|..:|               :||...
Human   530 KK--------TFKEPLSSLARKEGASSPVNGKDLDYVSTSKTQLVPSSKDGDVKDMLSRDRETSS 586

  Fly   452 NSKLAAKLAELEGQLVRGGKNLLDTYSERQIELEKKLVE---------------IAERKKREIEI 501
            ...|.:...:.|.:.:|.     ||...:.:..|:...|               :.||:||
Human   587 IEPLPSDSPKEELRPIRP-----DTPPSKPVAFEEFKNEQGSEINRIFKENKSILNERRKR---- 642

  Fly   502 QQQLELQEETTLEIR--ERNVSLEQEVELKKRKLSKCYAKY-----LALQQE-------LNDCKS 552
                  ..|||..|.  :|.:.:.:|....::.|.:...||     :.:.:|       |.|.|.
Human   643 ------ASETTQHINAIKREIDVTKEALNFQKSLREKQGKYENKGLMIIDEEEFLLILKLKDLKK 701

  Fly   553 DHN---QDLR----ELEMAQNELVKELKRQLLIIDNFVPIEVKQRLYTQAKYDEEQEEWKFSSMS 610
            .:.   ||||    |::..|: ||.:.:.:||:                     |.:.|...|..
Human   702 QYRSEYQDLRDLRAEIQYCQH-LVDQCRHRLLM---------------------EFDIWYNESFV 744

  Fly   611 LP------TPPGGD---GKFSSKRPVSHPQRRRPTSEYALQEAKSNSPSSLRF-----KSENIVN 661
            :|      ..|||.   |.....|.||..:..:.......|......|.|:.|     |.|...|
Human   745 IPEDMQMALKPGGSIRPGMVPVNRIVSLGEDDQDKFSQLQQRVLPEGPDSISFYNAKVKIEQKHN 809

  Fly   662 Y 662
            |
Human   810 Y 810

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp68D	NP_001261726.1	Motor_domain	18..344	CDD:277568	128/346 (37%)
		KISc	20..351	CDD:214526	129/351 (37%)
		GBP_C	<479..576	CDD:303769	27/132 (20%)
		coiled coil	547..558	CDD:293879	4/13 (31%)
KIF9	XP_005265445.1	KISc_KIF9_like	39..371	CDD:276826	127/343 (37%)
		Kinesin	45..373	CDD:278646	126/339 (37%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910