Protein Alignment Klp68D and kif1ab

DIOPT Version :10

• Sequence 1: NP_524029.2
• Gene: Klp68D / 39332
• FlyBaseID: FBgn0004381
• Length: 784
• Species: Drosophila melanogaster
• Sequence 2: XP_009296795.1
• Gene: kif1ab / 566766
• ZFINID: ZDB-GENE-070912-480
• Length: 1799
• Species: Danio rerio
• Alignment Length: 727
• Identity: 233/727 - (32%)
• Similarity: 339/727 - (46%)
• Gaps: 158/727 - (21%)

  Fly    20 VQVVVRCRPMSNRERSERSPEVVNVYPNRGVVELQNVVDGNKEQRKVFTYDAAYDASAT------ 78
            |:|.||.||.::||..:.|..::.:..|...:    :.....::.|.|.:|.:|.:..|
Zfish     6 VKVAVRVRPFNSREIGKDSKCIIQMSGNTTTI----LNPKQPKENKSFNFDYSYWSHTTPEDVNY 66

  Fly    79 --QTTLYHEVVFPLVSSVLEGFNGCIFAYGQTGTGKTFTMEGVRGNDELMGIIPRTFEQIWLHI- 140
              |..:|.::...::....||:|.|||||||||.||::||.|.:..|: .||||...|.::..|
Zfish    67 ACQKQVYRDIGEEMLLHAFEGYNVCIFAYGQTGAGKSYTMMGKQEKDQ-EGIIPLLCEDLFTKIN 130

  Fly   141 -NRTENFQFLVDVSYLEIYMEELRDLLKPNSK-HLEVRERG-SGVYVPNLHAINCKSVEDMIKVM 202
             |...|..:.|:|||:|||.|.:||||.|.:| :|.|||.. .|.||.:|..:...|..|:..:|
Zfish   131 DNNDNNMSYSVEVSYMEIYCERVRDLLNPKNKGNLRVREHPLMGPYVEDLSKLAVTSYNDIQDLM 195

  Fly   203 QVGNKNRTVGFTNMNEHSSRSHAIFMI----KIEMCDTETNTIKVGKLNLIDLAGSERQSKTGAS 263
            ..|||.|||..|||||.||||||:|.|    |....|:|..|.||.|::|:|||||||...|||.
Zfish   196 DSGNKARTVAATNMNETSSRSHAVFNIIFTQKQHDNDSENTTEKVSKISLVDLAGSERADSTGAK 260

  Fly   264 AERLKEASKINLALSSLGNVISALAE--SSPH-----------VPYRDSKLTRLLQDSLGGNSKT 315
            ..||||.:.||.:|::||.|||||||  |:|:           :|||||.||.||:::|||||:|
Zfish   261 GTRLKEGANINKSLTTLGKVISALAEMDSAPNKNKKKKKVESFIPYRDSVLTWLLRENLGGNSRT 325

  Fly   316 IMIANIGPSNYNYNETLTTLRYASRAKSIQNQPIKNEDPQDAKLKEYQEEIERLKRLIGPQ---- 376
            .|:|.:.|::.||:|||:|||||.|||.|:...:.||||.:..::|.:||:.|||.|:..|
Zfish   326 AMVAALSPADINYDETLSTLRYADRAKQIRCNAVINEDPNNRLVRELKEEVARLKDLLYAQGLGD 390

  Fly   377 ------QQQRSEKQVTAKKQRVKKPKKETVTKE---MSDSLQVSTIEQPVEDDS--------DPE 424
                  ..:.:...:.|..||   ....|||..   ||.|..:|.:...|...|        .|.
Zfish   391 IIENLSNYKANISSIQAVNQR---GDFSTVTNAMTGMSPSPSLSALTSRVGSISSLHDRIMFSPG 452

  Fly   425 GAES-ESDKENEAEVAKSN----EELERERVENSKLAAKLAELEGQLVRGGKNLLDTYSERQ--- 481
            ..|: |..||.|..:|:.|    |:|.|......:..|.|||: |..:|.....:..:|.::
Zfish   453 SEEAIERLKETEKIIAELNETWEEKLRRTEAIRMEREALLAEM-GVAMREDGGTVGVFSPKKTPH 516

  Fly   482 -IEL-EKKLVE----------IAERKKREIEIQQQLELQ-----------EETTLEIRERNVSLE 523
             :.| |..|:.          |.:..:.:...:|.:.|.           ..||..|.|..|.||
Zfish   517 LVNLNEDPLMSECLLYYIKDGITKVGREDASSRQDIVLSGHFIKDEHCIFTSTTNAIGEGTVVLE 581

  Fly   524 --------------------------------------QEVELKKRKLSKC-----------YAK 539
                                                  .|...:.|:.:.|           :|:
Zfish   582 PCEGAETYVNGKRVTEPTVLKSGNRIIMGKSHVFRFNDPEQARQDRERTPCADTPVEPVDWAFAQ 646

  Fly   540 YLALQQELNDCKSDHNQDLRELE-------------MAQNELVKELKRQLLIIDNFVPIEVKQRL 591
            ...|:::..|.|.:.:|.|:|||             :.|..|..|.|.:.|      ..:|..|.
Zfish   647 RELLEKQGIDMKQEMDQRLQELEDQYRKEREEASNLLEQQRLDYESKLEAL------QKQVNSRY 705

  Fly   592 YTQAKYDEEQEE 603
            |.:...:||:.|
Zfish   706 YPETTEEEEELE 717

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp68D	NP_524029.2	KISc	20..351	CDD:214526	155/359 (43%)
		Smc	<431..>580	CDD:440809	45/240 (19%)
kif1ab	XP_009296795.1	KISc_KIF1A_KIF1B	4..361	CDD:276816	155/359 (43%)
		Kinesin_assoc	358..538	CDD:465047	45/183 (25%)
		FHA	514..628	CDD:469597	14/113 (12%)
		ERM_helical	647..>702	CDD:466641	13/60 (22%)
		KIF1B	828..875	CDD:463574
		DUF3694	1273..1428	CDD:463599
		PH_KIFIA_KIFIB	1680..1782	CDD:269939