Protein Alignment Klp68D and kif21a

DIOPT Version :10

• Sequence 1: NP_524029.2
• Gene: Klp68D / 39332
• FlyBaseID: FBgn0004381
• Length: 784
• Species: Drosophila melanogaster
• Sequence 2: XP_009296478.1
• Gene: kif21a / 566481
• ZFINID: ZDB-GENE-110411-237
• Length: 1598
• Species: Danio rerio
• Alignment Length: 968
• Identity: 256/968 - (26%)
• Similarity: 379/968 - (39%)
• Gaps: 340/968 - (35%)

  Fly    20 VQVVVRCRPMSNRERSERSPEVVNVYPNRGVVELQNVVDGNKEQRKVFTYDAAYDASATQTTLYH 84
            |:|.:|.||...:|:.|.......|.|:...|.|      .|:  |.||||..:|..:||..:|.
Zfish     6 VRVALRIRPQLAKEKIEGCHICTFVMPDEPQVVL------GKD--KAFTYDYVFDMDSTQDNIYS 62

  Fly    85 EVVFPLVSSVLEGFNGCIFAYGQTGTGKTFTME---GVRGNDELMGIIPRTFEQIWLHINRTENF 146
            .....|:....||:|..||||||||:|||:||.   .|...||.:|||||....::..|.:....
Zfish    63 NCTEKLIEGCFEGYNATIFAYGQTGSGKTYTMGTGFDVAIPDEDLGIIPRAVTHLFKGIEQRRQQ 127

  Fly   147 ---------QFLVDVSYLEIYMEELRDLL--------KPNSKHLEVRERGS-GVYVPNLHAINCK 193
                     :|.:...:||:|.||:.||.        :....|:::.|..| |:|...:...|..
Zfish   128 AAEQSRPVPEFKISAQFLELYNEEVLDLFDTTRDMESRKQKSHIKIHEDASGGIYTVGVTTRNVS 192

  Fly   194 SVEDMIKVMQVGNKNRTVGFTNMNEHSSRSHAIFMI---KIEMC---------DTETNTIKVG-- 244
            |..:|::.:::|..:||...|.||..||||||||.|   :|.:|         |.||:....|
Zfish   193 SEAEMMQCLKLGALSRTTASTQMNVQSSRSHAIFTIHICQIRVCAPADSPPEQDNETDNRLAGSS 257

  Fly   245 -----------KLNLIDLAGSERQSKTGASAERLKEASKINLALSSLGNVISAL---AESSPHVP 295
                       |.:.:|||||||..:|||:.||.||...||..|.:||||||||   ::.|.|||
Zfish   258 SEMEEFETLTAKFHFVDLAGSERLKRTGATGERAKEGISINCGLLALGNVISALGDRSKRSTHVP 322

  Fly   296 YRDSKLTRLLQDSLGGNSKTIMIANIGPSNYNYNETLTTLRYASRAKSIQNQPIKNE-------- 352
            ||||||||||||||||||:|:|||.|.||:.::.|||.||:||:||::|:|:.:.|:
Zfish   323 YRDSKLTRLLQDSLGGNSRTVMIACISPSDQDFMETLNTLKYANRARNIKNKVMVNQDRASQQIS 387

  Fly   353 -----------------------------------------------------------DPQDAK 358
                                                                       |.|.|:
Zfish   388 ALRTEIARLQMELMEYRTGKRMVGEDGLESINDMFHENSMLQVENNNLRMRVKAMQEAIDAQGAR 452

  Fly   359 L--------------------------KEYQEEIERLK--------------------------- 370
            |                          :.|.:|||.|:
Zfish   453 LTQLLSQQANQLLARAGEGSEEIGNMIQNYIKEIEDLRAKLLESEAVNENLRRNLTRASSRPQFY 517

  Fly   371 --------RLIGPQQQQR-------SEKQVTAKKQRVKKPKK----------------------- 397
                    .|:||...|.       ::|.:...|:|.||.||
Zfish   518 GASGSFSTALLGPDPSQETSDIIEIAKKDLEKLKRREKKKKKRLQQLLADKRDEDEDEEEEVEED 582

  Fly   398 ------------ETVTKEMSDSLQVSTIEQPVEDDSDPEGAESESDKEN----EAEVAKSNEELE 446
                        :...||.|:    ||.::|..:.||.|..:.|.|:|:    |.|..:|:||.:
Zfish   583 SANKDETQEDGEQKTEKEQSE----STNQEPEMEASDREEGDGEEDEEDVEEEEMEAEESSEETD 643

  Fly   447 RERVENSKLAAKLAELEGQLVRGGKNLLDTYSERQIELEKKLVEIAERKKREIE-IQQQLE---- 506
            .|..|.....|.||.:                ..:|.:::||::..|..:|.:. ::||.|
Zfish   644 SELDEKEDFQADLANI----------------TCEIAIKQKLIDELENSQRRLHTLKQQYEHKLM 692

  Fly   507 -LQ---EETTLEIRERNV----SLEQEVELKKRKLSKCYAKYLALQQELNDCKSDHNQDLRELEM 563
             ||   .:|.|| |:|.:    |:|...|.|.:::...|.|.|::.          |::|::|:.
Zfish   693 MLQSKIRDTQLE-RDRVLHSMGSVESCSEDKTKRIKAEYEKKLSVM----------NKELQKLQA 746

  Fly   564 AQNELVKELKRQ--------LLIIDNFVPIEVKQRLYTQAKYDEEQEEWKFSSMSLPTPPGGDGK 620
            ||.|..:.||.|        .|.:|.....:.|.||..|.|  |:||:.:.:
Zfish   747 AQKEHARLLKNQSQYEKQLKKLQLDLTEMKKTKVRLMKQMK--EQQEKSRMA------------- 796

  Fly   621 FSSKR-----PVSHPQRRRPTSEYALQEAKSNSPSSLRFKSENIVNYELEMPCRTTQEYRTPKVS 680
             .|:|     .:...||::......|:..|......||.|:|.:          |....:...:|
Zfish   797 -ESRRNREIATLKKDQRKQEHQLKLLEAQKRQQELILRRKTEEV----------TALRRQVRPIS 850

  Fly   681 ASLQAVLAQAMQTGGDDIDIVDSHTNSLRSRLENIINANANGGAGPGAGVAVGSSIPN 738
            ..:                          :|..|:...|.:....|.||...||..||
Zfish   851 GKV--------------------------TRKANLSEPNFDLSHRPPAGRTYGSGAPN 882

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp68D	NP_524029.2	KISc	20..351	CDD:214526	150/379 (40%)
		Smc	<431..>580	CDD:440809	44/173 (25%)
kif21a	XP_009296478.1	KISc_KIF4	4..372	CDD:276823	148/373 (40%)
		GumC	304..>513	CDD:442439	58/208 (28%)
		EnvC	647..>856	CDD:443969	57/287 (20%)
		Laminin_I	905..>1091	CDD:310534
		Rcc_KIF21A	917..998	CDD:410204
		WD40	1266..1577	CDD:238121
		WD40 repeat	1278..1312	CDD:293791
		WD40 repeat	1317..1351	CDD:293791
		WD40 repeat	1371..1414	CDD:293791
		WD40 repeat	1420..1464	CDD:293791
		WD40 repeat	1471..1505	CDD:293791
		WD40 repeat	1512..1536	CDD:293791