Protein Alignment Klp68D and kif22

DIOPT Version :10

• Sequence 1: NP_524029.2
• Gene: Klp68D / 39332
• FlyBaseID: FBgn0004381
• Length: 784
• Species: Drosophila melanogaster
• Sequence 2: NP_001107063.1
• Gene: kif22 / 561788
• ZFINID: ZDB-GENE-080204-34
• Length: 634
• Species: Danio rerio
• Alignment Length: 686
• Identity: 194/686 - (28%)
• Similarity: 295/686 - (43%)
• Gaps: 161/686 - (23%)

  Fly    11 GSSQTPNECVQVVVRCRPMSNR--ERSERS------PEVVNVYPNRGVVE-LQNVVDGNKEQRKV 66
            ||.:|..  |:|.||.||..::  |:||.|      |:.:.:...|...| ||
Zfish    13 GSKRTSR--VRVAVRLRPYMDKQDEKSEGSCVRGLGPQKLEIINWRNATETLQ------------ 63

  Fly    67 FTYDAAYDASATQTTLYHEVVFPLVSSVLEGFNGCIFAYGQTGTGKTFTMEGVRGNDELMGIIPR 131
            :.:|..:....||..::...|.|::..:|.|.|..:||||.||.|||.||   .|:.|..|:|||
Zfish    64 YQFDVFHGEETTQQEVFLTSVKPILPHILNGQNASVFAYGPTGAGKTHTM---LGSQEQPGVIPR 125

  Fly   132 TFEQIWLHI----NRTENFQFLVDVSYLEIYMEELRDLLKPNSKHLEVRE-RGSGVYVPNLHAIN 191
            ..::::..:    ...:.:::.:.:||||||.|::.|||.|.|:.|.:|| :...:.:|.|....
Zfish   126 AVKEVFNLVGAQKKEQDGWEYSIGMSYLEIYNEKVLDLLSPGSQDLPIREDKDRNILIPGLTHTP 190

  Fly   192 CKSVEDMIKVMQVGNKNRTVGFTNMNEHSSRSHAIFMIKIEMCDT-ETNTIKVGKLNLIDLAGSE 255
            ..|..|........:.|||...|.:|:.|||||||.:||:..... ..:..:.|||.|:||||||
Zfish   191 LSSFADFDTHFIPASLNRTTASTKLNQRSSRSHAILLIKVVKSQRGPPHRQQTGKLYLVDLAGSE 255

  Fly   256 RQSKTGASAERLKEASKINLALSSLGNVISAL-AESSPHVPYRDSKLTRLLQDSLGGNSKTIMIA 319
            ...:||....||||:..|||:|.:|..|:.|| ..:...||||||||||||||||||::.::||.
Zfish   256 DNRRTGNQGIRLKESGAINLSLFTLSKVVDALNTGAGGRVPYRDSKLTRLLQDSLGGSAHSVMIT 320

  Fly   320 NIGPSNYNYNETLTTLRYASRAKSIQNQPIKNEDPQDAKLKEYQEEIERLKRLIGPQQQQRSEKQ 384
            ||.|....|.:|.:.|.:|:::|.|.|:|...|..              |...|.|.::.|.|::
Zfish   321 NIAPEYKYYFDTFSALNFAAKSKQIVNRPFVRETV--------------LAPTIAPGKRTREEQE 371

  Fly   385 VTAKKQRVKKPKKETVTKEMSDSLQVSTIEQPVEDDSDPEGAESESDKENEAEVAKSNEELERER 449
            .....:...|..||....|.|.|       .|:...|.|:
Zfish   372 AGGSGEPQNKRSKEGKKAEHSPS-------PPLHPQSSPD------------------------- 404

  Fly   450 VENSKLAAKLAELE----GQLVRGGKNLLDTYSERQIELEKKLVEIAERKKREIEIQQQL-ELQE 509
               |.:..:|..||    |...|...|||.|.::     .:|.:::.:.|::|:|.:..: ..|:
Zfish   405 ---SSVLDRLLALEKMMMGSAERERLNLLKTVAQ-----SRKEIQMLKEKQKELEDKANMFNKQK 461

  Fly   510 ETTLEIRERNVSLEQEVELKKRKLSKCYAKYLALQQELNDCKSDHNQDLRELEMAQNELVKELKR 574
            |||            |.|.|...|.|                    .||..|...|:...|..|:
Zfish   462 ETT------------EKESKDALLFK--------------------TDLPPLHRKQSTAAKPRKQ 494

  Fly   575 QLLIIDNFVPIEV---------------------KQRLYTQAKYDEEQEEWKFSSMSLPTPPGGD 618
            |.::    .|::|                     |:|:.|:....:|       ::.:..||..|
Zfish   495 QAVV----TPLQVSQVQPLQQCAVVCKPSQTLVKKKRVQTEVCDGKE-------NIGVDLPPVED 548

  Fly   619 GKFSSK-RPVSHPQRRRPTSEYALQEAKSNSPSSLR 653
            ..:.|: .|....|.|:.    .||...|.|...|:
Zfish   549 VNWESRLDPALLEQSRKK----ILQTLNSGSLKELK 580

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp68D	NP_524029.2	KISc	20..351	CDD:214526	128/346 (37%)
		Smc	<431..>580	CDD:440809	30/153 (20%)
kif22	NP_001107063.1	KISc_KID_like	19..343	CDD:276827	124/340 (36%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	357..406		13/83 (16%)
		GPS2_interact	393..468	CDD:464868	23/126 (18%)
		ComEA	571..620	CDD:441164	3/10 (30%)