DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Klp68D and kif9

DIOPT Version :9

Sequence 1:	NP_001261726.1	Gene:	Klp68D / 39332	FlyBaseID:	FBgn0004381	Length:	784	Species:	Drosophila melanogaster
Sequence 2:	XP_001922460.1	Gene:	kif9 / 553438	ZFINID:	ZDB-GENE-160728-129	Length:	764	Species:	Danio rerio

Alignment Length:	775	Identity:	213/775 - (27%)
Similarity:	334/775 - (43%)	Gaps:	174/775 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 VQVVVRCRPMSNRERSERSPEVVNVYPNRGVVELQNVVDGNKEQR----KVFTYDAA-YDASATQ 79
            |:|.:|.||.::     .:.|::...|::..:.:::.....|.:|    ::|..:.. |:.|  |
Zfish     8 VKVYIRIRPTAS-----FAHELIECLPDQQTLRVRSRKGSKKGKRNNHVRLFQLNGVLYNVS--Q 65

  Fly    80 TTLYHEVVFPLVSSVLEGFNGCIFAYGQTGTGKTFTMEGVRGNDELMGIIPRTFEQIWLHINRTE 144
            ..||..|...:|....:|:||.|..:||||.|||:||.|.....:..|||||..::::..:.:..
Zfish    66 EDLYDRVARSVVLGAFKGYNGTIMCFGQTGAGKTYTMTGAAETYKQRGIIPRAIQEVFQEVEQRA 130

  Fly   145 NFQFLVDVSYLEIYMEELRDLLK-------PNS-KHLEVRERGSGVYVPNLHAINCKSVEDMIKV 201
            ::.|.|.:|:||||.|.:.|||.       |.| ....|.|.|.||.|..|......:.|:.:.:
Zfish   131 DYTFSVHLSFLEIYNETMVDLLSSLKQGKAPGSGLFTVVEEPGGGVSVKGLSVHLVHNEEEALNL 195

  Fly   202 MQVGNKNRTVGFTNMNEHSSRSHAIFMIKIEMCDTETNTIK--VGKLNLIDLAGSERQSKTGASA 264
            :..|..||.:|...:|:||||||.||.|.||......:..|  ..||||:|||||||.||||:..
Zfish   196 LFEGEMNRIIGEHALNKHSSRSHCIFTIHIESRSRTLSEAKYITSKLNLVDLAGSERLSKTGSEG 260

  Fly   265 ERLKEASKINLALSSLGNVISALAES-SPHVPYRDSKLTRLLQDSLGGNSKTIMIANIGPSNYNY 328
            :...||..||.:||.|..||.|||:| ..|||:|.||||..|:||||||..|:::|||.......
Zfish   261 QVQMEAMYINKSLSFLEQVILALADSRREHVPFRQSKLTHALKDSLGGNCNTVLVANIYGDASQI 325

  Fly   329 NETLTTLRYASRAKSIQNQPIKNE--DPQDAKLKEYQEEIERLKRLIGP---------------- 375
            .|||:|||:|:|.|.:|.:|..||  ||. .::|..::||:.||..:..
Zfish   326 EETLSTLRFATRMKCVQTKPSINEHIDPV-IQVKRLEKEIQFLKEELSSYNPLTNRLTNEILSET 389

  Fly   376 ----------------------------------------QQQQRSEKQVTAKKQRVKKPKKET- 399
                                                    :||::.::|:..:..||:|....|
Zfish   390 QVEEVRTQVQRYLSGSLDEIPIVSSTQIQEVFSQFKKVMLEQQKKLQEQLCQRNTRVEKAMNTTP 454

  Fly   400 -VTKEMSD-----------SLQVSTIEQPVEDDSDPEGAESESDKE-NEAEVAKSNEELERERVE 451
             ...|.|:           .|.::...|..:....|:.:::.:||: |..|||..|..::...:.
Zfish   455 STVSEKSEGAVGEVESYGYGLGLAKSSQRHQQAVSPKSSKARNDKQINRKEVAAENSNVQPLTMS 519

  Fly   452 NSKLAA-KLAELEGQ---------------------------LVRGGKNLLDTYSERQIELEKKL 488
            .|.|.. |...||.|                           :::..|.:|   |||..:| :.|
Zfish   520 ESDLTTHKPQPLEEQQPTTDSPPPKAEAFEDFKAEQGSEINRILKENKAVL---SERTSQL-RAL 580

  Fly   489 VEIAERKKREI-----EIQQQLELQE----------ETTLEIRERNVSLEQEVELKKRKLSKCYA 538
            ..:....||||     :::|..|.::          |..||:.|  :||..:::..|.:..:.|.
Zfish   581 TNVINVTKREIDHITSDLRQFREQRQGQGEFMSADGEPVLEVEE--LSLVMKLKELKNRYRQTYE 643

  Fly   539 KYLALQQELNDCKSDHNQD----LRELEMAQNELVKELKRQLLIIDN------FVPIEVKQRLYT 593
            :....:.|:..|....||.    |.|.|...||........|.:::|      .:|::   :..|
Zfish   644 ELRTTETEIRYCAHLVNQCRMRLLTEFENWYNESFLLPGEVLSVLENGPVRPGHIPVD---KALT 705

  Fly   594 QAKYDEEQEEWKFSSMSLPTPPGGDGKFSSKRPVSHPQRRRPTSEYALQEAKSNSPSSLR 653
            ..:.|:.||            |..|    :...||:......|.:.......|.||.|:|
Zfish   706 LMEDDDPQE------------PHAD----TSSAVSYYNAYNRTLQRRGSRQVSQSPDSVR 749

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Klp68D	NP_001261726.1	Motor_domain	18..344	CDD:277568	130/339 (38%)
		KISc	20..351	CDD:214526	132/346 (38%)
		GBP_C	<479..576	CDD:303769	27/115 (23%)
		coiled coil	547..558	CDD:293879	3/14 (21%)
kif9	XP_001922460.1	Motor_domain	7..339	CDD:277568	129/337 (38%)
kif9	XP_001922460.1	Kinesin	13..339	CDD:278646	127/332 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4280
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810