DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Klp68D and KIF26B

DIOPT Version :9

Sequence 1:	NP_001261726.1	Gene:	Klp68D / 39332	FlyBaseID:	FBgn0004381	Length:	784	Species:	Drosophila melanogaster
Sequence 2:	NP_060482.2	Gene:	KIF26B / 55083	HGNCID:	25484	Length:	2108	Species:	Homo sapiens

Alignment Length:	919	Identity:	211/919 - (22%)
Similarity:	332/919 - (36%)	Gaps:	251/919 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 PGTGSSQTPNECVQVVVRCRPMSNRERSERSPEVVNVYPNRGVVEL--------QNVVD--GNKE 62
            ||.|.       |:|::|......|:.|| |...:.|.|.:..:.|        ||...  ||:.
Human   446 PGLGK-------VKVMLRICSTLARDTSE-SSSFLKVDPRKKQITLYDPLTCGGQNAFQKRGNQV 502

  Fly    63 QRKVFTYDAAYDASATQTTLYHEVVFPLVSSVLEGFNGCIFAYGQTGTGKTFTMEGVRGNDELMG 127
            ..|:|.:||.:...|:|..:....|..::.||:.|.:||:|.:|....||::||.|...:.:.:|
Human   503 PPKMFAFDAVFPQDASQAEVCAGTVAEVIQSVVNGADGCVFCFGHAKLGKSYTMIGKDDSMQNLG 567

  Fly   128 IIPRTFEQIWLHINRTE---NFQFLVDVSYLEIY--MEELRDLLKPNSKHLEVRERGSGVYVPNL 187
            |||.....::..||..:   ..:|.|.||.:|::  .|.|||||...:.......:..|||:
Human   568 IIPCAISWLFKLINERKEKTGARFSVRVSAVEVWGKEENLRDLLSEVATGSLQDGQSPGVYL--- 629

  Fly   188 HAINCKSVEDMIKVMQVGNKNR-------------TVGFTNMNEHSS--------RSHAIFMIKI 231
                |   ||.|...|:.|::.             .....:...|..        .||..|.:.|
Human   630 ----C---EDPICGTQLQNQSELRAPTAEKAAFFLDAAIASRRSHQQDCDEDDHRNSHVFFTLHI 687

  Fly   232 EMCDTETNTIKVGK---------LNLIDLAGSERQSKTGASAERLKEASKINLALSSLGNVISAL 287
            .....|    |.||         |:||||.     |...|.::..:..|.:.|:||:|||||.||
Human   688 YQYRME----KSGKGGMSGGRSRLHLIDLG-----SCVKALSKNREGGSGLCLSLSALGNVILAL 743

  Fly   288 AESSPHVPYRDSKLTRLLQDSLGG-NSKTIMIANIGPSNYNYNETLTTLRYASRAKSIQNQPIKN 351
            ...|.|:||::|||..||::|||. |.:|.|||:|..:..:|.|||:|::.|||...::.:..|.
Human   744 VNGSKHIPYKESKLAMLLRESLGNMNCRTTMIAHISAAVGSYAETLSTIQIASRVLRMKKKKTKY 808

  Fly   352 EDPQDAKLKEYQEEIERLKR----------------------------------------LIGPQ 376
            ...........:|  .|::|                                        .|||.
Human   809 TSSSSGGESSCEE--GRMRRPTQLRPFHTRATVDPDFPIAHLSSDPDYSSSSEQSCDTVIYIGPN 871

  Fly   377 QQQRSEKQVTAKKQRVKKPKKETVTKEMSDSLQVSTIEQPVEDDSDPEGAESESDKENEAEVAKS 441
            ....|:|::|.             .:...|.:.:....|....||.|..|...:..::|.:..|.
Human   872 GTALSDKELTD-------------NEGPPDFVPIVPALQKTRGDSRPAEAGEAAAGKSERDCLKC 923

  Fly   442 NEELE-RERVE-----NSKLAAKLAELEGQLVRGGKNLLDTYSERQIELEKKLVE------IAER 494
            |...| :||::     ....:....||..|           :...|.....:|.:      ::|.
Human   924 NTFAELQERLDCIDGSEEPSSFPFEELPAQ-----------FGPEQASRGPRLSQAAGASPLSES 977

  Fly   495 KKREIEIQQQLELQEETTLEIRERNVSLEQEVELKKRKLSKCYAKYLALQQELNDCKSDHN---- 555
            .|.:...:.||     |..|..|...|..|.........:..::...|..:.:....|.|:
Human   978 DKEDNGSEGQL-----TNREGPELPASKMQRSHSPVPAAAPAHSPSPASPRSVPGSSSQHSASPL 1037

  Fly   556 ------QDLRE-------------------LEMAQNELVKELKRQLLIIDNFVPIEVKQR--LYT 593
                  |..||                   |.:|......|.|         .|....||  :||
Human  1038 VQSPSLQSSRESLNSCGFVEGKPRPMGSPRLGIASLSKTSEYK---------PPSSPSQRCKVYT 1093

  Fly   594 QAKYDEEQEEWKFSSMSLPTPPGG-DGKFSSKRPVSHPQRRRP---TSEYALQEAKSNSPSSLRF 654
            |.         .......|.||.. |...:|:..:..|:.|.|   .|...|:  ||.|..|..|
Human  1094 QK---------GVLPSPAPLPPSSKDSGVASRESLLQPEVRTPPVGMSPQVLK--KSMSAGSEGF 1147

  Fly   655 KSENIVNYELEMPCRTTQEYRTP-----KVSASLQAVLAQAMQTGGDD---IDIVDSHTNS--LR 709
            .         |.|....|:..||     ::.::....:.|.::..|:|   ..:|:..|.|  |.
Human  1148 P---------ETPVDDEQQAATPSESKKEILSTTMVTVQQPLELNGEDELVFTLVEELTISGVLD 1203

  Fly   710 S-RLENIINANAN-------GGAGPGAGVAVGSSIPN----------VRNIKSSRGLPSAASNLD 756
            | |..:||:.|::       .|:.|   |::.|||..          |..:..::.||....:||
Human  1204 SGRPTSIISFNSDCSARALASGSRP---VSIISSISEDLECYSSTAPVSEVSITQFLPLPKMSLD 1265

  Fly   757 SNRRPPTGR 765
            ...:....|
Human  1266 EKAQDAGSR 1274

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Klp68D	NP_001261726.1	Motor_domain	18..344	CDD:277568	112/371 (30%)
		KISc	20..351	CDD:214526	112/376 (30%)
		GBP_C	<479..576	CDD:303769	21/131 (16%)
		coiled coil	547..558	CDD:293879	3/20 (15%)
KIF26B	NP_060482.2	KISc	450..798	CDD:276812	111/374 (30%)
		KISc	451..798	CDD:214526	111/366 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	805..825		3/21 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	876..917		9/53 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	937..1166		50/273 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1406..1504
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1519..1653
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1685..1799
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1814..1974
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..124
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	263..287
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4280
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.900