Protein Alignment Klp68D and KIF26B

DIOPT Version :10

• Sequence 1: NP_524029.2
• Gene: Klp68D / 39332
• FlyBaseID: FBgn0004381
• Length: 784
• Species: Drosophila melanogaster
• Sequence 2: NP_060482.2
• Gene: KIF26B / 55083
• HGNCID: 25484
• Length: 2108
• Species: Homo sapiens
• Alignment Length: 919
• Identity: 211/919 - (22%)
• Similarity: 332/919 - (36%)
• Gaps: 251/919 - (27%)

  Fly     8 PGTGSSQTPNECVQVVVRCRPMSNRERSERSPEVVNVYPNRGVVEL--------QNVVD--GNKE 62
            ||.|.       |:|::|......|:.|| |...:.|.|.:..:.|        ||...  ||:.
Human   446 PGLGK-------VKVMLRICSTLARDTSE-SSSFLKVDPRKKQITLYDPLTCGGQNAFQKRGNQV 502

  Fly    63 QRKVFTYDAAYDASATQTTLYHEVVFPLVSSVLEGFNGCIFAYGQTGTGKTFTMEGVRGNDELMG 127
            ..|:|.:||.:...|:|..:....|..::.||:.|.:||:|.:|....||::||.|...:.:.:|
Human   503 PPKMFAFDAVFPQDASQAEVCAGTVAEVIQSVVNGADGCVFCFGHAKLGKSYTMIGKDDSMQNLG 567

  Fly   128 IIPRTFEQIWLHINRTE---NFQFLVDVSYLEIY--MEELRDLLKPNSKHLEVRERGSGVYVPNL 187
            |||.....::..||..:   ..:|.|.||.:|::  .|.|||||...:.......:..|||:
Human   568 IIPCAISWLFKLINERKEKTGARFSVRVSAVEVWGKEENLRDLLSEVATGSLQDGQSPGVYL--- 629

  Fly   188 HAINCKSVEDMIKVMQVGNKNR-------------TVGFTNMNEHSS--------RSHAIFMIKI 231
                |   ||.|...|:.|::.             .....:...|..        .||..|.:.|
Human   630 ----C---EDPICGTQLQNQSELRAPTAEKAAFFLDAAIASRRSHQQDCDEDDHRNSHVFFTLHI 687

  Fly   232 EMCDTETNTIKVGK---------LNLIDLAGSERQSKTGASAERLKEASKINLALSSLGNVISAL 287
            .....|    |.||         |:||||.     |...|.::..:..|.:.|:||:|||||.||
Human   688 YQYRME----KSGKGGMSGGRSRLHLIDLG-----SCVKALSKNREGGSGLCLSLSALGNVILAL 743

  Fly   288 AESSPHVPYRDSKLTRLLQDSLGG-NSKTIMIANIGPSNYNYNETLTTLRYASRAKSIQNQPIKN 351
            ...|.|:||::|||..||::|||. |.:|.|||:|..:..:|.|||:|::.|||...::.:..|.
Human   744 VNGSKHIPYKESKLAMLLRESLGNMNCRTTMIAHISAAVGSYAETLSTIQIASRVLRMKKKKTKY 808

  Fly   352 EDPQDAKLKEYQEEIERLKR----------------------------------------LIGPQ 376
            ...........:|  .|::|                                        .|||.
Human   809 TSSSSGGESSCEE--GRMRRPTQLRPFHTRATVDPDFPIAHLSSDPDYSSSSEQSCDTVIYIGPN 871

  Fly   377 QQQRSEKQVTAKKQRVKKPKKETVTKEMSDSLQVSTIEQPVEDDSDPEGAESESDKENEAEVAKS 441
            ....|:|::|.             .:...|.:.:....|....||.|..|...:..::|.:..|.
Human   872 GTALSDKELTD-------------NEGPPDFVPIVPALQKTRGDSRPAEAGEAAAGKSERDCLKC 923

  Fly   442 NEELE-RERVE-----NSKLAAKLAELEGQLVRGGKNLLDTYSERQIELEKKLVE------IAER 494
            |...| :||::     ....:....||..|           :...|.....:|.:      ::|.
Human   924 NTFAELQERLDCIDGSEEPSSFPFEELPAQ-----------FGPEQASRGPRLSQAAGASPLSES 977

  Fly   495 KKREIEIQQQLELQEETTLEIRERNVSLEQEVELKKRKLSKCYAKYLALQQELNDCKSDHN---- 555
            .|.:...:.||     |..|..|...|..|.........:..::...|..:.:....|.|:
Human   978 DKEDNGSEGQL-----TNREGPELPASKMQRSHSPVPAAAPAHSPSPASPRSVPGSSSQHSASPL 1037

  Fly   556 ------QDLRE-------------------LEMAQNELVKELKRQLLIIDNFVPIEVKQR--LYT 593
                  |..||                   |.:|......|.|         .|....||  :||
Human  1038 VQSPSLQSSRESLNSCGFVEGKPRPMGSPRLGIASLSKTSEYK---------PPSSPSQRCKVYT 1093

  Fly   594 QAKYDEEQEEWKFSSMSLPTPPGG-DGKFSSKRPVSHPQRRRP---TSEYALQEAKSNSPSSLRF 654
            |.         .......|.||.. |...:|:..:..|:.|.|   .|...|:  ||.|..|..|
Human  1094 QK---------GVLPSPAPLPPSSKDSGVASRESLLQPEVRTPPVGMSPQVLK--KSMSAGSEGF 1147

  Fly   655 KSENIVNYELEMPCRTTQEYRTP-----KVSASLQAVLAQAMQTGGDD---IDIVDSHTNS--LR 709
            .         |.|....|:..||     ::.::....:.|.::..|:|   ..:|:..|.|  |.
Human  1148 P---------ETPVDDEQQAATPSESKKEILSTTMVTVQQPLELNGEDELVFTLVEELTISGVLD 1203

  Fly   710 S-RLENIINANAN-------GGAGPGAGVAVGSSIPN----------VRNIKSSRGLPSAASNLD 756
            | |..:||:.|::       .|:.|   |::.|||..          |..:..::.||....:||
Human  1204 SGRPTSIISFNSDCSARALASGSRP---VSIISSISEDLECYSSTAPVSEVSITQFLPLPKMSLD 1265

  Fly   757 SNRRPPTGR 765
            ...:....|
Human  1266 EKAQDAGSR 1274

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp68D	NP_524029.2	KISc	20..351	CDD:214526	112/376 (30%)
		Smc	<431..>580	CDD:440809	30/189 (16%)
KIF26B	NP_060482.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..124
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	263..287
		KISc	450..798	CDD:276812	111/374 (30%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	805..825		3/21 (14%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	876..917		9/53 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	937..1166		50/273 (18%)
		PLN03209	<946..1196	CDD:178748	54/294 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1406..1504
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1519..1653
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1685..1799
		PHA03307	1703..>1970	CDD:223039
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1824..1974