DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Klp68D and kif3a

DIOPT Version :9

Sequence 1:	NP_001261726.1	Gene:	Klp68D / 39332	FlyBaseID:	FBgn0004381	Length:	784	Species:	Drosophila melanogaster
Sequence 2:	NP_001017604.2	Gene:	kif3a / 550267	ZFINID:	ZDB-GENE-050417-71	Length:	701	Species:	Danio rerio

Alignment Length:	709	Identity:	289/709 - (40%)
Similarity:	437/709 - (61%)	Gaps:	61/709 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 VQVVVRCRPMSNRERSERSPEVVNVYPNRGVVELQNVVDGNKEQRKVFTYDAAYDASATQTTLYH 84
            |:|||||||::.:|:.....:.|.|...||.:.: |.:|.:.|..|.||:|..:...:.|..:|:
Zfish    18 VKVVVRCRPLNEKEKIMGHKQSVTVDEIRGTITV-NKLDISSEPPKTFTFDTVFGPDSKQLDVYN 81

  Fly    85 EVVFPLVSSVLEGFNGCIFAYGQTGTGKTFTMEGVRGNDELMGIIPRTFEQIWLHINRTE-NFQF 148
            ....|::.|||||:||.|||||||||||||||||||...||.||||.:|..::.||.:.| :.:|
Zfish    82 LTARPIIDSVLEGYNGTIFAYGQTGTGKTFTMEGVRAVPELRGIIPNSFAHVFGHIAKAEGDTRF 146

  Fly   149 LVDVSYLEIYMEELRDLL-KPNSKHLEVRERGS-GVYVPNLHAINCKSVEDMIKVMQVGNKNRTV 211
            ||.|||||||.||:|||| |...:.|||:||.. |||:.:|......:.:||.::|.:|:|||:|
Zfish   147 LVRVSYLEIYNEEVRDLLGKDQMQRLEVKERPDVGVYIKDLSGYVVNNADDMDRIMTLGHKNRSV 211

  Fly   212 GFTNMNEHSSRSHAIFMIKIEMCDTE----TNTIKVGKLNLIDLAGSERQSKTGASAERLKEASK 272
            |.||||||||||||||.|.|| |..:    ...:::|||:|:||||||||.||||:.:|||||:|
Zfish   212 GATNMNEHSSRSHAIFTITIE-CSEKGVDGNQHVRMGKLHLVDLAGSERQGKTGATGQRLKEATK 275

  Fly   273 INLALSSLGNVISALAE-SSPHVPYRDSKLTRLLQDSLGGNSKTIMIANIGPSNYNYNETLTTLR 336
            |||:||:||||||||.: .|.|||||:|||||||||||||||||:|.|||||::|||:||::|||
Zfish   276 INLSLSTLGNVISALVDGKSTHVPYRNSKLTRLLQDSLGGNSKTMMCANIGPADYNYDETISTLR 340

  Fly   337 YASRAKSIQNQPIKNEDPQDAKLKEYQEEIERLKRLI----------GPQQQQRSEKQV--TAKK 389
            ||:|||:|:|:...||||:||.|:::|:|||.||:.:          |.......|..|  ..::
Zfish   341 YANRAKNIKNKARINEDPKDALLRQFQKEIEELKKKLEEGEEISGSDGSGSDDMDEDDVGDGGER 405

  Fly   390 QRVKKPKKETVTKEMSDSLQVSTIEQPVEDDSDPEGAESESDKENE------AEVAKSNEELERE 448
            :|.::.:|:....:|        :|...:.:.:.:..|::.|.|.|      ||:.|..::|.:.
Zfish   406 RRKRRGRKKVSPDKM--------VEMQAKIEEERKALEAKLDMEEEERNKARAELEKREKDLLKA 462

  Fly   449 RVENSKLAAKLAELEGQLVRGGKNLLDTYSERQIELEKKLVEIAERKKREIEIQQQLELQEETTL 513
            :.|:..|..||:.||.:::.||.:||....|::..||:...|:.||:||..:::::||.:|:..|
Zfish   463 QQEHHLLLEKLSALEKRVIVGGVDLLAKAEEQEKLLEESNNELEERRKRAEQLRRELEEKEQERL 527

  Fly   514 EIRERNVSLEQEVELKKRKLSKCYAKYLALQQELNDCKSDHNQDLRELEMAQNELVKELKRQLLI 578
            :|.|:..||::|.:.|.:||.|.:...:|.:.|:.|.:.:|::::..|.....:|.:||:.|:||
Zfish   528 DIEEKYTSLQEEAQGKTKKLKKVWTMLMAAKSEMADLQQEHHREIEGLLENIRQLSRELRLQMLI 592

  Fly   579 IDNFVPIEVKQRLYTQAKYDEEQEEWKFSSMSLPTPPGGDGKFSSKRPVSHPQRRRP----TSEY 639
            ||||:|.|.::.:.....::|:..||:...::..     ......:.|||..:.:.|    .|..
Zfish   593 IDNFIPQEYQEMIENYVHWNEDIGEWQLKCVAYT-----GNNMRKQTPVSDKKEKDPFEVDLSHV 652

  Fly   640 ALQEAKSNSPSSLRFKSENIVNYELEMPCRTTQEYRT-PKV-----SASLQAVLAQAMQ 692
            .|...:.:...||         .:||.| ||::..:: ||.     |:..:||:...:|
Zfish   653 YLAYTEESMRQSL---------MKLERP-RTSKNGKSRPKTGRRKRSSKPEAVIESLLQ 701

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Klp68D	NP_001261726.1	Motor_domain	18..344	CDD:277568	189/331 (57%)
		KISc	20..351	CDD:214526	191/338 (57%)
		GBP_C	<479..576	CDD:303769	29/96 (30%)
		coiled coil	547..558	CDD:293879	2/10 (20%)
kif3a	NP_001017604.2	KISc_KIF3	16..348	CDD:276822	189/331 (57%)
kif3a	NP_001017604.2	Kinesin	23..348	CDD:278646	185/326 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4280
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D145782at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101005
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.720